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Quantification of absolute myocardial perfusion at rest and during exercise with positron emission tomography after human cardiac transplantation.

Abstract：

:The maximal exercise capacity of cardiac transplant recipients is reduced compared with that of normal subjects. To determine if this reduced exercise capacity is related to inadequate myocardial perfusion during exercise, myocardial perfusion was measured noninvasively with use of positron emission tomography and nitrogen (N)-13 ammonia. Twelve transplant recipients with no angiographic evidence of accelerated coronary atherosclerosis were studied. Serial N-13 ammonia imaging was performed at rest and during supine bicycle exercise. The results were compared with those from 10 normal volunteers with a low probability of having cardiac disease. A two-compartment kinetic model for estimating myocardial perfusion was applied to the data. Transplant recipients achieved a significant lower exercise work load than did the volunteers (42 +/- 16 vs. 128 +/- 22 W), but a higher venous lactate concentration (31.3 +/- 14.9 vs. 13.7 +/- 4.1 mg/100 ml). Despite the difference in exercise work load, there was no significant difference in the cardiac work achieved by transplant recipients and normal subjects as evidenced by similar rate-pressure products of 24,000 +/- 3,400 versus 21,300 +/- 2,800 betas/min per mm Hg, respectively. In addition, myocardial blood flow during exercise was not significantly different between the two groups (1.70 +/- 0.60 vs. 1.56 +/- 0.71 ml/min per g, respectively). This study demonstrates that the myocardial flow response to the physiologic stress of exercise is appropriate in transplant recipients and does not appear to explain the decreased exercise capacity in these patients.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Krivokapich J,Stevenson LW,Kobashigawa J,Huang SC,Schelbert HR

doi

10.1016/0735-1097(91)90608-c

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

512-7

issue

2

eissn

0735-1097

issn

1558-3597

pii

0735-1097(91)90608-C

journal_volume

18

pub_type

杂志文章

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