Abstract：
:To evaluate the risks of and optimal method for valve dilation in aortic stenosis, balloons of different sizes were used to dilate the normal aortic root in 16 lambs and then stenotic valves in 15 children. In the lambs, inflated balloon to aortic anulus diameter ratios ranged from 0.9 to 1.5. These hearts were examined immediately after the procedure. Ratios of 0.9 to 1.1 did not produce significant damage to the left ventricular outflow tract, whereas those of 1.2 to 1.5 produced tears or hematomas, or both, of the aortic valve leaflets (n = 3), mitral valve leaflets (n = 4) and interventricular septum (n = 4). The 15 patients, aged 10 days to 15 years, underwent 16 balloon aortic valvotomy procedures. The balloon-aortic anulus ratio ranged from 0.67 to 1.1 (mean 0.90). The average pressure gradient decreased 69% and, overall, the peak systolic gradient decreased from 86 +/- 21 to 28 +/- 14 mm Hg (p less than 0.01) and the aortic valve area increased from 0.44 +/- 0.11 to 0.73 +/- 0.22 cm2/m2 (p less than 0.01). Immediately after the procedure an increase in aortic regurgitation was noted in 8 (57%) of 14 patients, but was never greater than 3+ and has been well tolerated. Other early complications encountered consisted of transient left bundle branch block in two patients, temporary femoral artery occlusion in three and femoral artery rupture requiring operative management in one infant. Balloon valvotomy can reduce the transvalvular gradient in most patients with valvular aortic stenosis when a balloon less than 1.1 times the aortic root diameter is used.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Helgason H,Keane JF,Fellows KE,Kulik TJ,Lock JEdoi
10.1016/s0735-1097(87)80237-1subject
Has Abstractpub_date
1987-04-01 00:00:00pages
816-22issue
4eissn
0735-1097issn
1558-3597pii
S0735-1097(87)80237-1journal_volume
9pub_type
杂志文章abstract：OBJECTIVES:The purpose of this study was to validate existing 12-lead electrocardiographic (ECG) ST-segment elevation myocardial infarction (STEMI) criteria in the diagnosis of acute myocardial infarction (AMI) and the application of similar ST-segment depression (STEMI-equivalent) criteria with contrast-enhanced cardi...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2007.04.090
更新日期：2007-09-11 00:00:00
abstract：:Iodine-123 phenylpentadecanoic acid (IPPA) is a synthetic long chain fatty acid with myocardial kinetics similar to palmitate. Two hypotheses were tested in this study. The first hypothesis was that IPPA imaging with single photon emission computed tomography (SPECT) is useful in the identification of patients with co...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(88)90359-2
更新日期：1988-07-01 00:00:00
abstract：:The initial and late outcome of coronary angioplasty was studied in 148 patients less than 40 years of age (mean 36.4 +/- 3). Angioplasty was performed on a single vessel in 70% of patients and on multiple vessels in 30%; it was performed on a totally occluded vessel in 20%. Angioplasty was successful in 90.5% of pati...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章
doi：10.1016/0735-1097(90)90302-6
更新日期：1990-12-01 00:00:00
abstract：BACKGROUND:Persistent severe left ventricular (LV) systolic dysfunction after myocardial infarction (MI) is associated with increased mortality and is a class I indication for implantation of a cardioverter-defibrillator. OBJECTIVES:This study developed models and assessed independent predictors of LV recovery to >35%...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jacc.2015.12.042
更新日期：2016-03-15 00:00:00
abstract：:Sixteen patients with double-outlet right ventricle, aged 1 week to 29 years (median 5 months), were studied with a 1.5 tesla nuclear magnetic resonance (NMR) imaging scanner. Two-dimensional echocardiography was performed in all patients. Thirteen patients underwent angiography, including nine who underwent subsequen...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(10)80237-2
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:In patients with resistant hypertension (RH) and obstructive sleep apnea (OSA), the blood pressure response to continuous positive airway pressure (CPAP) treatment is highly variable and could be associated with differential micro-ribonucleic acid (miRNA) profiles. Currently, no available methods exist to id...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jacc.2015.06.1315
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to assess the efficacy of radiofrequency catheter ablation (RFCA) in the treatment of hypertrophic obstructive cardiomyopathy in children. BACKGROUND:Hypertrophic obstructive cardiomyopathy is an uncommon cause of left ventricular outflow tract obstruction in children. In symptomat...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2011.09.020
更新日期：2011-12-06 00:00:00
abstract：OBJECTIVES:We sought to determine if natriuretic peptides are associated with estrogen and androgen status in a population study of young women without known cardiac disease. BACKGROUND:Circulating concentrations of plasma B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are higher in women than in m...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2006.10.040
更新日期：2007-01-02 00:00:00
abstract：:Therapeutic fibrinolysis has been dominated by the experience with tissue-type plasminogen activator (t-PA), which proved little better than streptokinase in acute myocardial infarction. In contrast, endogenous fibrinolysis, using one-thousandth of the t-PA concentration, is regularly lysing fibrin and induced Thrombo...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2016.07.780
更新日期：2016-11-08 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine the effect of resolution from metabolic syndrome (MetS) between youth and adulthood on carotid artery intima-media thickness (IMT) and type 2 diabetes mellitus (T2DM). BACKGROUND:Published findings demonstrate that youth with MetS are at increased risk of cardio-metaboli...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jacc.2012.05.056
更新日期：2012-10-23 00:00:00
abstract：:Anisoylated plasminogen streptokinase activator complex (APSAC) is a new thrombolytic agent that is of interest because of its ease of administration as an intravenous bolus injection. This report describes the first double-blind, placebo-controlled evaluation of intravenous APSAC for coronary recanalization in acute ...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0735-1097(87)80181-x
更新日期：1987-07-01 00:00:00
abstract：OBJECTIVES:This study tested the hypothesis that angiotensin II may inhibit the forearm vascular resistance response to an increase in arterial pressure in normal humans. BACKGROUND:Angiotensin II inhibits baroreflex-mediated reductions in heart rate and peripheral sympathetic activity during increases in arterial pre...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(95)96225-n
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVES:We sought to determine the efficacy of isradipine in reducing left ventricular (LV) mass and wall thickness in hypertensive patients. BACKGROUND:LV hypertrophy on the echocardiogram is a strong predictor of cardiovascular events. Reduction of LV mass may be a desirable goal of drug therapy for hypertension....
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0735-1097(97)00311-2
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:Quantitative flow ratio (QFR) is a novel angiography-based method for deriving fractional flow reserve (FFR) without pressure wire or induction of hyperemia. The accuracy of QFR when assessed online in the catheterization laboratory has not been adequately examined to date. OBJECTIVES:The goal of this study...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.jacc.2017.10.035
更新日期：2017-12-26 00:00:00
abstract：:There is a close interrelationship between atrial fibrillation (AF) and atrial flutter (AFL). Atrial fibrillation of variable duration precedes the onset of AFL in almost all instances; during AF, the functional components needed to complete the AFL re-entrant circuit, principally a line of block (LoB) between the ven...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2007.08.066
更新日期：2008-02-26 00:00:00
abstract：OBJECTIVES:We sought to determine whether the amount of myocardial ischemic burden differs in patients with painful or silent myocardial hypoperfusion during exercise testing. BACKGROUND:Whether a lack of symptoms during ischemia reflects an alteration in pain perception or less myocardium in jeopardy remains a contro...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(97)00006-5
更新日期：1997-04-01 00:00:00
abstract：:Regulations and restrictions imposed by external agencies are forcing cardiologists into an unnatural self-protective and defensive posture against their patients. The key to breaking the pattern of mutual skepticism and mistrust lies in returning the focus to its rightful place: the patients' needs. Thus, payment sys...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(92)90630-6
更新日期：1992-06-01 00:00:00
abstract：OBJECTIVES:This study compared the effect of changes in action potential duration versus conduction velocity on atrial flutter cycle length to determine whether there is a fully or partially excitable gap in atrial flutter. BACKGROUND:In an excitable gap reentrant circuit, cycle length is proportional to conduction ve...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(95)00459-9
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to investigate the expression of perforin and T-cell intracellular antigen-1, two crucial components of lymphocyte-mediated cytotoxicity, in endomyocardial biopsies from patients with idiopathic dilated cardiomyopathy. BACKGROUND:Previous reports have demonstrated the presence ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(96)00475-5
更新日期：1997-02-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to compare the frequency of angiographic restenosis and clinical events between a paclitaxel-eluting stent (PES) and a similar bare-metal stent (BMS) in saphenous vein graft (SVG) lesions. BACKGROUND:There are conflicting and mostly retrospective data on outcomes after drug-eluting...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jacc.2008.11.029
更新日期：2009-03-17 00:00:00
abstract：OBJECTIVES:The purpose of this study was to determine the risk of adverse cardiovascular events associated with concomitant use of clopidogrel and calcium-channel blockers (CCBs) in patients with myocardial infarction (MI). BACKGROUND:CCBs inhibit a variety of cytochrome P-450 enzymes, some of which contribute to clop...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2010.08.640
更新日期：2011-01-25 00:00:00
abstract：OBJECTIVES:The aim of this study was to compare metabolic risk factors in men with anginal chest pain and a normal or abnormal coronary angiogram with those in healthy men. BACKGROUND:Risk factors for coronary heart disease, including lipoprotein abnormalities, hypertension and adiposity, may be metabolically interlin...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(94)90423-5
更新日期：1994-02-01 00:00:00
abstract：:Poorly controlled type 2 diabetes mellitus is associated with the development of cardiovascular and renal complications, resulting in significant morbidity and mortality. Intensive glycemic control has been a major focus for clinical trials and novel drug development. However, narrow treatment strategies developed str...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2019.09.022
更新日期：2019-11-19 00:00:00
abstract：OBJECTIVES:This study attempted to assess myocardial sympathetic innervation using iodine-123 (I-123) metaidobenzylguanidine (MIBG) imaging in patients with familial amyloid polyneuropathy. BACKGROUND:Signs and symptoms of cardiac autonomic dysfunction are commonly seen in patients with cardiac amyloidosis. However, t...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(96)00438-x
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Cardiomyopathies are usually inherited and predominantly affect adults, but they can also present in childhood. Although our understanding of the molecular basis of pediatric cardiomyopathy has improved, the underlying mechanism remains elusive in a substantial proportion of cases. OBJECTIVES:This study aim...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2015.10.093
更新日期：2016-02-09 00:00:00
abstract：OBJECTIVES:This study was undertaken to determine the ability of the signal-averaged electrocardiogram (ECG) to identify evidence of delayed atrial activation in patients with a history of atrial fibrillation. BACKGROUND:Atrial fibrillation is a reentrant rhythm and depends on atrial conduction delay for its developme...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(93)90381-a
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND:Pulmonary vascular disease, pulmonary endothelial dysfunction, liver fibrosis, renal disease, and exercise intolerance are common in adults with Fontan physiology. Although the pathophysiologic mechanisms linking these phenomena have been studied, certain aspects are not well understood. OBJECTIVES:This stu...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2020.10.003
更新日期：2020-12-08 00:00:00
abstract：:In a series of 24 consecutive patients referred to the echocardiography laboratory because of suspected patent foramen ovale, contrast two-dimensional and M-mode echocardiographic studies were performed during normal breathing and during two provocative tests: the Valsalva maneuver and cough. A right to left shunt was...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(84)80106-0
更新日期：1984-09-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to examine the association of diabetic retinopathy with incident heart failure (HF). BACKGROUND:Microvascular disease might play a more prominent role in the pathogenesis of diabetic cardiomyopathy, a major cause of HF in diabetes. Whether diabetic retinopathy, a microvascular ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2007.11.076
更新日期：2008-04-22 00:00:00
abstract：:To determine whether long-term blood pressure levels correlate with left ventricular mass, echocardiographic measurements were performed in 152 men and 299 women who were participants in the Framingham Heart Study. All subjects were free of obesity and cardiovascular and pulmonary disease, were not taking antihyperten...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(91)90549-o
更新日期：1991-11-01 00:00:00
