Differential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy.

Abstract:

OBJECTIVES:We hypothesized that an amlodipine-based regimen would have more favorable effects on left ventricular (LV) diastolic function. BACKGROUND:Different antihypertensive therapies may vary in their effect on LV diastolic function. METHODS:The HACVD (Hypertension Associated Cardiovascular Disease) substudy of ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) collected detailed cardiovascular phenotypic data on a subset of 1,006 participants recruited from 2 centers (St. Mary's Hospital, London, and Beaumont Hospital, Dublin). Conventional and tissue Doppler echocardiography and measurement of plasma B-type natriuretic peptide (BNP) were performed approximately 1 year after randomization to atenolol-based or amlodipine-based antihypertensive treatment to assess LV diastolic function. RESULTS:On-treatment blood pressure (BP) (mean +/- SD) was similar in both groups: atenolol-based regimen, systolic BP of 137 +/- 17 mm Hg, diastolic BP of 82 +/- 9 mm Hg; amlodipine-based regimen, systolic BP of 136 +/- 15 mm Hg, diastolic BP of 80 +/- 9 mm Hg. Ejection fraction did not differ between groups, but early diastolic mitral annular velocity (E'), a measure of diastolic relaxation, was lower in patients on the atenolol-based regimen: atenolol-based regimen, 7.9 +/- 1.8; amlodipine-based regimen, 8.8 +/- 2.0. A measure of left ventricular filling pressure, E/E', and BNP were significantly higher in patients on the atenolol-based regimen. Differences in E', E/E', and BNP remained significant after adjustment for age and sex. Further adjustment for systolic BP, LV mass index, and heart rate had no impact on differences in mean E' or BNP. The difference in E/E' was attenuated. CONCLUSIONS:Patients receiving treatment with an amlodipine-based regimen had better diastolic function than patients treated with the atenolol-based regimen. Treatment-related differences in diastolic function were independent of BP reduction and other factors that are known to affect diastolic function.

journal_name

J Am Coll Cardiol

authors

Tapp RJ,Sharp A,Stanton AV,O'Brien E,Chaturvedi N,Poulter NR,Sever PS,Thom SA,Hughes AD,Mayet J,ASCOT Investigators.

doi

10.1016/j.jacc.2009.11.084

subject

Has Abstract

pub_date

2010-04-27 00:00:00

pages

1875-81

issue

17

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(10)00694-7

journal_volume

55

pub_type

杂志文章
  • Reproducibility of two-dimensional exercise echocardiography.

    abstract::To determine the reproducibility of two-dimensional exercise echocardiography, duplicate studies were performed on the same patients a median of 14 days apart. Because measurements are operator-dependent, interobserver variability was calculated for two experienced readers who interpreted the findings independently in...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(89)90467-1

    authors: Oberman A,Fan PH,Nanda NC,Lee JY,Huster WJ,Sulentic JA,Storey OF

    更新日期:1989-10-01 00:00:00

  • Electroanatomic mapping of arrhythmogenic right ventricular dysplasia.

    abstract:OBJECTIVES:We tested the hypothesis that spatial association of low-amplitude intracardiac electrograms can identify the presence, location and extent of dysplastic regions in arrhythmogenic right ventricular dysplasia (ARVD). BACKGROUND:Arrhythmogenic right ventricular dysplasia is a right ventricular (RV) cardiomyop...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(01)01625-4

    authors: Boulos M,Lashevsky I,Reisner S,Gepstein L

    更新日期:2001-12-01 00:00:00

  • Prognostic value of N-terminal proatrial natriuretic factor plasma levels measured within the first 12 hours after myocardial infarction. Thrombolysis in Myocardial Infarction (TIMI) II Investigators.

    abstract:OBJECTIVES:The aim of the present study was to examine the relation between the plasma levels of the atrial peptide N-terminal proatrial natriuretic factor (proANF) measured during the 1st 12 h after myocardial infarction and 1-year mortality. BACKGROUND:The atrial peptides atrial natriuretic factor and N-terminal pro...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(95)00342-8

    authors: Hall C,Cannon CP,Forman S,Braunwald E

    更新日期:1995-11-15 00:00:00

  • The changing face of heart transplantation.

    abstract::It has been 40 years since the first human-to-human heart transplant performed in South Africa by Christiaan Barnard in December 1967. This achievement did not come as a surprise to the medical community but was the result of many years of early pioneering experimental work by Alexis Carrel, Frank Mann, Norman Shumway...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2008.05.020

    authors: Hunt SA,Haddad F

    更新日期:2008-08-19 00:00:00

  • Prognostic value of fractional flow reserve: linking physiologic severity to clinical outcomes.

    abstract:BACKGROUND:Fractional flow reserve (FFR) has become an established tool for guiding treatment, but its graded relationship to clinical outcomes as modulated by medical therapy versus revascularization remains unclear. OBJECTIVES:The study hypothesized that FFR displays a continuous relationship between its numeric val...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jacc.2014.07.973

    authors: Johnson NP,Tóth GG,Lai D,Zhu H,Açar G,Agostoni P,Appelman Y,Arslan F,Barbato E,Chen SL,Di Serafino L,Domínguez-Franco AJ,Dupouy P,Esen AM,Esen OB,Hamilos M,Iwasaki K,Jensen LO,Jiménez-Navarro MF,Katritsis DG,Kocam

    更新日期:2014-10-21 00:00:00

  • The prevalence, incidence and prognostic value of the Brugada-type electrocardiogram: a population-based study of four decades.

    abstract:OBJECTIVES:We sought to demonstrate the prevalence, incidence and prognostic value of the Brugada-type electrocardiogram (ECG) in a general population. BACKGROUND:The Brugada syndrome is characterized by evidence of right bundle branch block and ST segment elevation in the right precordial leads, as well as sudden dea...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(01)01421-8

    authors: Matsuo K,Akahoshi M,Nakashima E,Suyama A,Seto S,Hayano M,Yano K

    更新日期:2001-09-01 00:00:00

  • Preprocedural C-reactive protein levels and cardiovascular events after coronary stent implantation.

    abstract:OBJECTIVES:This study assessed the predictive value of preprocedural C-reactive protein (CRP) levels on six-month clinical and angiographic outcome in patients undergoing coronary stent implantation. BACKGROUND:Recent data indicate that low-grade inflammation as detected by elevated CRP serum levels predicts the risk ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(00)01193-1

    authors: Walter DH,Fichtlscherer S,Sellwig M,Auch-Schwelk W,Schächinger V,Zeiher AM

    更新日期:2001-03-01 00:00:00

  • Effect of lesion characteristics on outcome of directional coronary atherectomy.

    abstract::Directional coronary atherectomy, a new transluminal procedure for treatment of obstructive lesions in coronary arteries by excision and removal of tissue, was performed on 447 lesions in 382 procedures. Successful outcome, defined as a reduction of stenosis by greater than or equal to 20% with a less than 50% residua...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(91)90840-6

    authors: Hinohara T,Rowe MH,Robertson GC,Selmon MR,Braden L,Leggett JH,Vetter JW,Simpson JB

    更新日期:1991-04-01 00:00:00

  • Autologous bone marrow stem cell mobilization induced by granulocyte colony-stimulating factor after subacute ST-segment elevation myocardial infarction undergoing late revascularization: final results from the G-CSF-STEMI (Granulocyte Colony-Stimulating

    abstract:OBJECTIVES:The purpose of this investigator-driven, prospective, randomized, double-blinded, placebo-controlled phase II study was to compare the effects of granulocyte colony-stimulating factor (G-CSF) on the improvement of myocardial function in patients undergoing delayed percutaneous coronary intervention (PCI) for...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jacc.2006.07.044

    authors: Engelmann MG,Theiss HD,Hennig-Theiss C,Huber A,Wintersperger BJ,Werle-Ruedinger AE,Schoenberg SO,Steinbeck G,Franz WM

    更新日期:2006-10-17 00:00:00

  • Diagnostic approach and proposed criteria for the clinical diagnosis of Takayasu's arteriopathy.

    abstract::The criteria proposed for the clinical diagnosis of Takayasu's disease (chronic inflammatory arteriopathy of unknown origin) were based on clinical and angiographic data from 108 Japanese patients: 96 with Takayasu's disease and 12 with another disease of the aorta. The criteria consist of one obligatory criterion (ag...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(88)90462-7

    authors: Ishikawa K

    更新日期:1988-10-01 00:00:00

  • Magnetic resonance imaging of arrhythmogenic right ventricular dysplasia: sensitivity, specificity, and observer variability of fat detection versus functional analysis of the right ventricle.

    abstract:OBJECTIVES:The purpose of this study was to determine interobserver agreement for interpretation of magnetic resonance imaging (MRI) examinations of arrhythmogenic right ventricular dysplasia (ARVD) and to determine sensitivity and specificity of fat detection versus functional parameters measured by MRI. BACKGROUND:T...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2006.07.051

    authors: Tandri H,Castillo E,Ferrari VA,Nasir K,Dalal D,Bomma C,Calkins H,Bluemke DA

    更新日期:2006-12-05 00:00:00

  • 1-year risk-adjusted mortality and costs of percutaneous coronary intervention in the Veterans Health Administration: insights from the VA CART Program.

    abstract:BACKGROUND:There is significant interest in measuring health care value, but this concept has not been operationalized in specific patient cohorts. The longitudinal outcomes and costs for patients after percutaneous coronary intervention (PCI) provide an opportunity to measure an aspect of health care value. OBJECTIVE...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2014.10.048

    authors: Ho PM,O'Donnell CI,Bradley SM,Grunwald GK,Helfrich C,Chapko M,Liu CF,Maddox TM,Tsai TT,Jesse RL,Fihn SD,Rumsfeld JS

    更新日期:2015-01-27 00:00:00

  • Association of contemporary sensitive troponin I levels at baseline and change at 1 year with long-term coronary events following myocardial infarction or unstable angina: results from the LIPID Study (Long-Term Intervention With Pravastatin in Ischaemic

    abstract:OBJECTIVES:This study sought to assess whether baseline and change in contemporary sensitive troponin I (TnI) levels predicts coronary heart disease (CHD) death and myocardial infarction (MI), and to determine the effects of pravastatin on TnI levels. BACKGROUND:The role of troponins in predicting long-term outcomes i...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jacc.2013.08.1643

    authors: White HD,Tonkin A,Simes J,Stewart R,Mann K,Thompson P,Colquhoun D,West M,Nestel P,Sullivan D,Keech AC,Hunt D,Blankenberg S,LIPID Study Investigators.

    更新日期:2014-02-04 00:00:00

  • Physiologic assessment of coronary artery stenosis by coronary flow reserve measurements with transthoracic Doppler echocardiography: comparison with exercise thallium-201 single piston emission computed tomography.

    abstract:OBJECTIVES:We evaluated the value of coronary flow reserve (CFR), as determined by transthoracic Doppler echocardiography (TTDE), for physiologic assessment of coronary artery stenosis severity, and we compared TTDE measurements with those obtained by exercise thallium-201 (Tl-201) single-photon emission computed tomog...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(01)01167-6

    authors: Daimon M,Watanabe H,Yamagishi H,Muro T,Akioka K,Hirata K,Takeuchi K,Yoshikawa J

    更新日期:2001-04-01 00:00:00

  • A randomized trial to evaluate the relative protection against post-percutaneous coronary intervention microvascular dysfunction, ischemia, and inflammation among antiplatelet and antithrombotic agents: the PROTECT-TIMI-30 trial.

    abstract:OBJECTIVES:The goal of this study was to evaluate glycoprotein IIb/IIIa inhibition with eptifibatide when administered with indirect thrombin inhibition as compared with monotherapy with direct thrombin inhibition with bivalirudin among patients with non-ST-segment elevation acute coronary syndromes (ACS). BACKGROUND:...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jacc.2005.12.077

    authors: Gibson CM,Morrow DA,Murphy SA,Palabrica TM,Jennings LK,Stone PH,Lui HH,Bulle T,Lakkis N,Kovach R,Cohen DJ,Fish P,McCabe CH,Braunwald E,TIMI Study Group.

    更新日期:2006-06-20 00:00:00

  • Impact of coronary risk factors on contribution of nitric oxide and adenosine to metabolic coronary vasodilation in humans.

    abstract:OBJECTIVES:The contribution of nitric oxide (NO) and adenosine to the increase in coronary blood flow (CBF) induced by cardiac pacing was investigated in 28 subjects with angiographically normal coronary arteries with and without one or more risk factors for atherosclerosis. BACKGROUND:NO and adenosine are important i...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(98)00095-3

    authors: Minamino T,Kitakaze M,Matsumura Y,Nishida K,Kato Y,Hashimura K,Matsu-Ura Y,Funaya H,Sato H,Kuzuya T,Hori M

    更新日期:1998-05-01 00:00:00

  • Eicosanoid biosynthesis in patients with stable angina: beneficial effects of very low dose aspirin.

    abstract:OBJECTIVE:We assessed the production of eicosanoids and the effects of very low dose aspirin in patients with stable angina under basal conditions and during rapid atrial pacing. BACKGROUND:Platelet activation occurs in acute ischemic syndromes but is still controversial in stable angina. Very low dose aspirin is know...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/0735-1097(94)90538-x

    authors: Montalescot G,Maclouf J,Drobinski G,Salloum J,Grosgogeat Y,Thomas D

    更新日期:1994-07-01 00:00:00

  • Sudden death in a pediatric cardiology population, 1958 to 1983: relation to prior arrhythmias.

    abstract::This review of sudden death in patients previously seen in a pediatric cardiology clinic attempts to identify factors that may have been predictive of sudden death. The denominator for these factors is unknown. For example, the number of patients with these possible risk factors who have well tolerated arrhythmias is ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(85)80543-x

    authors: Garson A Jr,McNamara DG

    更新日期:1985-06-01 00:00:00

  • Characterization of Myocardial Injury in Patients With COVID-19.

    abstract:BACKGROUND:Myocardial injury is frequent among patients hospitalized with coronavirus disease-2019 (COVID-19) and is associated with a poor prognosis. However, the mechanisms of myocardial injury remain unclear and prior studies have not reported cardiovascular imaging data. OBJECTIVES:This study sought to characteriz...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jacc.2020.08.069

    authors: Giustino G,Croft LB,Stefanini GG,Bragato R,Silbiger JJ,Vicenzi M,Danilov T,Kukar N,Shaban N,Kini A,Camaj A,Bienstock SW,Rashed ER,Rahman K,Oates CP,Buckley S,Elbaum LS,Arkonac D,Fiter R,Singh R,Li E,Razuk V,Ro

    更新日期:2020-11-03 00:00:00

  • Effects of amiodarone and its active metabolite desethylamiodarone on the ventricular defibrillation threshold.

    abstract:OBJECTIVES:We evaluated whether the reported difference in the ventricular defibrillation threshold (DFT) between short-term intravenous and oral amiodarone is due to the effect of amiodarone's active metabolite desethylamiodarone (DEA). BACKGROUND:Amiodarone is frequently used in patients with implantable cardioverte...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(98)00160-0

    authors: Zhou L,Chen BP,Kluger J,Fan C,Chow MS

    更新日期:1998-06-01 00:00:00

  • A nonsteroid anti-inflammatory drug exacerbates Coxsackie B3 murine myocarditis.

    abstract::Nonsteroid anti-inflammatory drugs are often used to treat myalgias and arthralgias in enteroviral infections, but their effects on acute viral myocarditis are unknown. The effect of the nonsteroidal anti-inflammatory drug, ibuprofen, on acute viral myocarditis was studied in 75 four week old male BALB/c mice infected...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(85)80312-0

    authors: Costanzo-Nordin MR,Reap EA,O'Connell JB,Robinson JA,Scanlon PJ

    更新日期:1985-11-01 00:00:00

  • Nonsurgical septal reduction therapy for hypertrophic obstructive cardiomyopathy: one-year follow-up.

    abstract:OBJECTIVE:The objective of this study is to evaluate the one-year outcome of the first 50 patients who underwent nonsurgical septal reduction for symptomatic hypertrophic obstructive cardiomyopathy at our institution. BACKGROUND:Left ventricular outflow tract obstruction is an important determinant of clinical symptom...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0735-1097(00)00767-1

    authors: Lakkis NM,Nagueh SF,Dunn JK,Killip D,Spencer WH 3rd

    更新日期:2000-09-01 00:00:00

  • Treatment of obstructive sleep apnea reduces the risk of atrial fibrillation recurrence after catheter ablation.

    abstract:OBJECTIVES:The aim of this study was to examine the effect of continuous positive airway pressure (CPAP) therapy on atrial fibrillation (AF) recurrence in patients with obstructive sleep apnea (OSA) undergoing pulmonary vein isolation (PVI). BACKGROUND:OSA is a predictor of AF recurrence following PVI. However, the im...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2013.03.052

    authors: Fein AS,Shvilkin A,Shah D,Haffajee CI,Das S,Kumar K,Kramer DB,Zimetbaum PJ,Buxton AE,Josephson ME,Anter E

    更新日期:2013-07-23 00:00:00

  • Economics of elective coronary revascularization. Comparison of costs and charges for conventional angioplasty, directional atherectomy, stenting and bypass surgery.

    abstract:OBJECTIVES:This study was designed to evaluate more closely the true in-hospital costs of elective revascularization by directional coronary atherectomy and intracoronary stenting and to compare these costs with those of the traditional revascularization alternatives (i.e., conventional balloon angioplasty and coronary...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(93)90415-w

    authors: Cohen DJ,Breall JA,Ho KK,Weintraub RM,Kuntz RE,Weinstein MC,Baim DS

    更新日期:1993-10-01 00:00:00

  • 18Fluorodeoxyglucose Accumulation in Arterial Tissues Determined by PET Signal Analysis.

    abstract:BACKGROUND:Arterial 18fluorodeoxyglucose (FDG) positron emission tomography (PET) is considered a measure of atherosclerotic plaque macrophages and is used for quantification of disease activity in clinical trials, but the distribution profile of FDG across macrophages and other arterial cells has not been fully clarif...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2019.06.057

    authors: Al-Mashhadi RH,Tolbod LP,Bloch LØ,Bjørklund MM,Nasr ZP,Al-Mashhadi Z,Winterdahl M,Frøkiær J,Falk E,Bentzon JF

    更新日期:2019-09-03 00:00:00

  • Vascular effects of apelin in vivo in man.

    abstract:OBJECTIVES:This study was designed to establish the direct vascular effects of apelin in vivo in man. BACKGROUND:Apelin is the endogenous ligand for the previously orphaned G-protein-coupled receptor, APJ. This novel pathway is widely expressed in the cardiovascular system and is emerging as an important mediator of c...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2008.06.013

    authors: Japp AG,Cruden NL,Amer DA,Li VK,Goudie EB,Johnston NR,Sharma S,Neilson I,Webb DJ,Megson IL,Flapan AD,Newby DE

    更新日期:2008-09-09 00:00:00

  • Cardiac resynchronization therapy: a novel adjunct to the treatment and prevention of systemic right ventricular failure.

    abstract:OBJECTIVES:This study aimed to evaluate the technical feasibility and hemodynamic benefit of cardiac resynchronization therapy (CRT) in patients with systemic right ventricle (RV). BACKGROUND:Patients with a systemic RV are at high risk of developing heart failure. Cardiac resynchronization therapy may improve RV func...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2004.08.044

    authors: Janousek J,Tomek V,Chaloupecký VA,Reich O,Gebauer RA,Kautzner J,Hucín B

    更新日期:2004-11-02 00:00:00

  • Endothelial cell recovery between comparator polymer-based drug-eluting stents.

    abstract:OBJECTIVES:The purpose of this study was to assess trends in endothelial coverage and recovery among leading polymer-based drug-eluting stents (DES). BACKGROUND:Autopsy studies of human U.S. Food and Drug Administration (FDA)-approved DES implanted coronary arteries suggest that complications of late stent thrombosis ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2008.04.030

    authors: Joner M,Nakazawa G,Finn AV,Quee SC,Coleman L,Acampado E,Wilson PS,Skorija K,Cheng Q,Xu X,Gold HK,Kolodgie FD,Virmani R

    更新日期:2008-07-29 00:00:00

  • Neointimal thickening after stent delivery of paclitaxel: change in composition and arrest of growth over six months.

    abstract:OBJECTIVES:The purpose of this study was to determine long-term effects of stent-based paclitaxel delivery on amount, rate and composition of neointimal thickening after stent implantation. BACKGROUND:Paclitaxel prevents vascular smooth muscle cell proliferation and migration in vitro and in vivo. These actions, coupl...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(00)01020-2

    authors: Drachman DE,Edelman ER,Seifert P,Groothuis AR,Bornstein DA,Kamath KR,Palasis M,Yang D,Nott SH,Rogers C

    更新日期:2000-12-01 00:00:00

  • Do associations with C-reactive protein and extent of coronary artery disease account for the increased cardiovascular risk of renal insufficiency?

    abstract:OBJECTIVES:We sought to determine whether the association of higher C-reactive protein levels (CRP) and more extensive coronary artery disease (CAD) explains the high cardiovascular risk of renal insufficiency (RI). BACKGROUND:Renal insufficiency and renal failure (RF) have been associated with increased cardiovascula...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(03)00564-3

    authors: Zebrack JS,Anderson JL,Beddhu S,Horne BD,Bair TL,Cheung A,Muhlestein JB,Intermountain Heart Collaborative Study Group.

    更新日期:2003-07-02 00:00:00