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Antithrombotic Therapy to Prevent Recurrent Strokes in Ischemic Cerebrovascular Disease: JACC Scientific Expert Panel.

Abstract：

:Stroke survivors carry a high risk of recurrence. Antithrombotic medications are paramount for secondary prevention and thus crucial to reduce the overall stroke burden. Appropriate antithrombotic agent selection should be based on the best understanding of the physiopathological mechanism that led to the initial ischemic injury. Antiplatelet therapy is preferred for lesions characterized by atherosclerosis and endothelial injury, whereas anticoagulant agents are favored for cardiogenic embolism and highly thrombophilic conditions. Large randomized controlled trials have provided new data to support recommendations for the evidence-based use of antiplatelet agents and anticoagulant agents after stroke. In this review, the authors cover recent trials that have altered clinical practice, cite systematic reviews and meta-analyses, review evidence-based recommendations based on older landmark trials, and indicate where there are still evidence-gaps and new trials being conducted.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Del Brutto VJ,Chaturvedi S,Diener HC,Romano JG,Sacco RL

doi

10.1016/j.jacc.2019.06.039

subject

Has Abstract

pub_date

2019-08-13 00:00:00

pages

786-803

issue

6

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(19)35696-7

journal_volume

74

pub_type

杂志文章,评审

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