当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Patent foramen ovale and the risk of ischemic stroke in a multiethnic population.

Patent foramen ovale and the risk of ischemic stroke in a multiethnic population.

Abstract：

OBJECTIVES:We sought to assess the risk of ischemic stroke from a patent foramen ovale (PFO) in the multiethnic prospective cohort of northern Manhattan. BACKGROUND:Patent foramen ovale has been associated with increased risk of ischemic stroke, mainly in case-control studies. The actual PFO-related stroke risk in the general population is unclear. METHODS:The presence of PFO was assessed at baseline by using transthoracic 2-dimensional echocardiography with contrast injection in 1,100 stroke-free subjects older than 39 years of age (mean age 68.7 +/- 10.0 years) from the Northern Manhattan Study (NOMAS). The presence of atrial septal aneurysm (ASA) also was recorded. Subjects were followed annually for outcomes. We assessed PFO/ASA-related stroke risk after adjusting for established stroke risk factors. RESULTS:We detected PFO in 164 subjects (14.9%); ASA was present in 27 subjects (2.5%) and associated with PFO in 19 subjects. During a mean follow-up of 79.7 +/- 28.0 months, an ischemic stroke occurred in 68 subjects (6.2%). After adjustment for demographics and risk factors, PFO was not found to be significantly associated with stroke (hazard ratio 1.64, 95% confidence interval [CI] 0.87 to 3.09). The same trend was observed in all age, gender, and race-ethnic subgroups. The coexistence of PFO and ASA did not increase the stroke risk (adjusted hazard ratio 1.25, 95% CI 0.17 to 9.24). Isolated ASA was associated with elevated stroke incidence (2 of 8, or 25%; adjusted hazard ratio 3.66, 95% CI 0.88 to 15.30). CONCLUSIONS:Patent foramen ovale, alone or together with ASA, was not associated with an increased stroke risk in this multiethnic cohort. The independent role of ASA needs further assessment in appositely designed and powered studies.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Di Tullio MR,Sacco RL,Sciacca RR,Jin Z,Homma S

doi

10.1016/j.jacc.2006.08.063

subject

Has Abstract

pub_date

2007-02-20 00:00:00

pages

797-802

issue

7

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(06)02995-0

journal_volume

49

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Alteration of left ventricular diastolic function during coronary angioplasty-induced ischemia: a color M-mode Doppler study.

    abstract：OBJECTIVES:The aim of this study was to assess the effects of ischemia on diastolic function by analyzing flow propagation velocity with color M-mode Doppler echocardigraphy. BACKGROUND:Color M-mode Doppler echocardiography has been proposed as a method of assessing left ventricular filling. METHODS:Color M-mode Dopp...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(97)00052-1

    authors： Duval-Moulin AM,Dupouy P,Brun P,Zhuang F,Pelle G,Perez Y,Teiger E,Castaigne A,Gueret P,Dubois-Randé JL

    更新日期：1997-05-01 00:00:00

  • The implanted defibrillator: relation of defibrillating lead configuration and clinical variables to defibrillation threshold.

    abstract：:Forty-two defibrillating lead systems for the automatic implantable defibrillator were implanted and tested in 41 patients. Two basic lead configurations were used: 1) spring-patch, consisting of a transvenous superior vena cava spring electrode as the anode and an apical or left lateral ventricular patch electrode (e...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80219-9

    authors： Troup PJ,Chapman PD,Olinger GN,Kleinman LH

    更新日期：1985-12-01 00:00:00

  • Wearable cardioverter-defibrillator use in patients perceived to be at high risk early post-myocardial infarction.

    abstract：OBJECTIVES:The aim of this study was to describe usage of the wearable cardioverter-defibrillator (WCD) during mandated waiting periods following myocardial infarction (MI) for patients perceived to be at high risk for sudden cardiac arrest (SCA). BACKGROUND:Current device guidelines and insurance coverage require wai...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2013.05.086

    authors： Epstein AE,Abraham WT,Bianco NR,Kern KB,Mirro M,Rao SV,Rhee EK,Solomon SD,Szymkiewicz SJ

    更新日期：2013-11-19 00:00:00

  • Assessment of right ventricular performance by pulsed Doppler echocardiography in patients after intraatrial repair of aortopulmonary transposition in infancy or childhood.

    abstract：:The purpose of this study was to determine whether measurement of aortic blood flow velocity and acceleration by pulsed Doppler ultrasound can be used to assess the global performance of the systemic right ventricle noninvasively in young patients who have undergone intraatrial repair of aortopulmonary transposition. ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(89)90352-5

    authors： Schmidt KG,Cloez JL,Silverman NH

    更新日期：1989-06-01 00:00:00

  • The prognostic significance of first myocardial infarction type (Q wave versus non-Q wave) and Q wave location. The Multicenter Diltiazem Post-Infarction Research Group.

    abstract：:The prognostic significance of the type of first acute myocardial infarction (Q wave versus non-Q wave) and Q wave location (anterior versus inferoposterior) was determined from a multicenter data base involving 777 placebo-treated patients who were participants in the Multicenter Diltiazem Post-Infarction Trial. Ther...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0735-1097(10)80001-4

    authors： Benhorin J,Moss AJ,Oakes D,Marcus F,Greenberg H,Dwyer EM Jr,Algeo S,Hahn E

    更新日期：1990-05-01 00:00:00

  • Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure.

    abstract：OBJECTIVES:We investigated the effects of a novel ultrapotent poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor, PJ34, on cardiac and endothelial dysfunction in a rat model of chronic heart failure (CHF). BACKGROUND:Overactivation of the nuclear enzyme PARP importantly contributes to the development of ce...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)02062-4

    authors： Pacher P,Liaudet L,Mabley Jg,Komjáti K,Szabó C

    更新日期：2002-09-04 00:00:00

  • Laser catheter-induced atrioventricular nodal delays and atrioventricular block in dogs: acute and chronic observations.

    abstract：:Selective modification of atrioventricular (AV) nodal conduction, that is, induction of varying degrees of AV nodal delays or block (second or third degree), or both, was achieved with a pervenous laser catheter technique. In six adult mongrel dogs anesthetized with pentobarbital (Nembutal), 5F leads were placed throu...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80045-0

    authors： Narula OS,Boveja BK,Cohen DM,Narula JT,Tarjan PP

    更新日期：1985-02-01 00:00:00

  • The prevalence of coronary artery calcium among diabetic individuals without known coronary artery disease.

    abstract：OBJECTIVES:We sought to examine the age and gender distribution of coronary artery calcium (CAC) by diabetes status in a large cohort of asymptomatic individuals. BACKGROUND:Among individuals with diabetes, coronary artery disease (CAD) is a major cause of morbidity and mortality. Electron-beam tomography (EBT) quanti...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)02975-3

    authors： Hoff JA,Quinn L,Sevrukov A,Lipton RB,Daviglus M,Garside DB,Ajmere NK,Gandhi S,Kondos GT

    更新日期：2003-03-19 00:00:00

  • Constriction of a large coronary artery contributes to serotonin-induced myocardial ischemia in the dog with pliable coronary stenosis.

    abstract：:To clarify the role of serotonin in eliciting myocardial ischemia, the effects of serotonin on coronary vasculature and cardiac performance were examined in anesthetized open chest dogs. Without coronary stenosis, intracoronary infusion of serotonin (0.001 to 1.0 micrograms/kg per min) for 40 s caused dose-dependent i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(89)90201-5

    authors： Ichikawa Y,Yokoyama M,Akita H,Fukuzaki H

    更新日期：1989-08-01 00:00:00

  • Quantitative comparison of spontaneous and paced 12-lead electrocardiogram during right ventricular outflow tract ventricular tachycardia.

    abstract：OBJECTIVES:The purpose of this study was to objectively quantify the similarity of 12-lead electrocardiogram (ECG) waveforms using two quantitative metrics, the correlation coefficient (CORR) and the mean absolute deviation (MAD). BACKGROUND:Comparison of the 12-lead ECG morphology between ventricular tachycardia (VT)...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(03)00427-3

    authors： Gerstenfeld EP,Dixit S,Callans DJ,Rajawat Y,Rho R,Marchlinski FE

    更新日期：2003-06-04 00:00:00

  • Effectiveness of fludrocortisone and salt in preventing syncope recurrence in children: a double-blind, placebo-controlled, randomized trial.

    abstract：OBJECTIVES:We sought to evaluate the effectiveness of salt and fludrocortisone versus placebo in the prevention of syncope recurrence in children. BACKGROUND:Intravascular volume expansion with fludrocortisone and salt has been reported to be effective in the treatment of syncope in children. However, no pediatric pla...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jacc.2004.11.033

    authors： Salim MA,Di Sessa TG

    更新日期：2005-02-15 00:00:00

  • Renal artery stent placement: utility in lesions difficult to treat with balloon angioplasty.

    abstract：OBJECTIVES:We assessed the safety and efficacy of stent placement in patients with poorly controlled hypertension and renal artery stenoses, which are difficult to treat with balloon angioplasty alone. BACKGROUND:Preliminary experience with stent placement suggests improved results over balloon angioplasty alone in pa...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0735-1097(97)00348-3

    authors： White CJ,Ramee SR,Collins TJ,Jenkins JS,Escobar A,Shaw D

    更新日期：1997-11-15 00:00:00

  • Gender differences in molecular remodeling in pressure overload hypertrophy.

    abstract：OBJECTIVES:The objective of this study was to examine gender differences in left ventricular (LV) function and expression of cardiac genes in response to LV pressure overload due to ascending aortic stenosis in rats. BACKGROUND:Clinical studies have documented gender differences in the pattern of adaptive LV hypertrop...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00165-5

    authors： Weinberg EO,Thienelt CD,Katz SE,Bartunek J,Tajima M,Rohrbach S,Douglas PS,Lorell BH

    更新日期：1999-07-01 00:00:00

  • Application of a computerized medical decision-making process to the problem of digoxin intoxication.

    abstract：:A computerized medical decision-making system was used to monitor signs and predisposing factors of digoxin intoxication in patients receiving digoxin. This process automatically reviewed the patient's data base nightly for drug interactions, laboratory data and electrocardiographic findings with known association wit...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0735-1097(84)80104-7

    authors： White KS,Lindsay A,Pryor TA,Brown WF,Walsh K

    更新日期：1984-09-01 00:00:00

  • Multivessel Palmaz-Schatz stenting: early results and one-year outcome.

    abstract：OBJECTIVES:To determine whether the benefits outlined in Background might extend to patients with multivessel disease, we examined the short- and long-term outcome of multivessel Palmaz-Schatz stenting. BACKGROUND:Percutaneous transluminal coronary angioplasty (PTCA) has become the dominant treatment for most patients...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(97)00146-0

    authors： Laham RJ,Ho KK,Baim DS,Kuntz RE,Cohen DJ,Carrozza JP Jr

    更新日期：1997-07-01 00:00:00

  • Ideal Cardiovascular Health, Mortality, and Vascular Events in Elderly Subjects: The Three-City Study.

    abstract：BACKGROUND:The benefit of ideal cardiovascular health (CVH) on health-related outcomes in middle-aged patients is firmly established. In the growing elderly population, the high prevalence of comorbidities and medications for chronic diseases may offset such benefit. OBJECTIVES:This study analyzed the association of i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2017.05.011

    authors： Gaye B,Canonico M,Perier MC,Samieri C,Berr C,Dartigues JF,Tzourio C,Elbaz A,Empana JP

    更新日期：2017-06-27 00:00:00

  • Innervation patterns may limit response to endovascular renal denervation.

    abstract：BACKGROUND:Renal denervation is a new interventional approach to treat hypertension with variable results. OBJECTIVES:The purpose of this study was to correlate response to endovascular radiofrequency ablation of renal arteries with nerve and ganglia distributions. We examined how renal neural network anatomy affected...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2014.07.937

    authors： Tzafriri AR,Mahfoud F,Keating JH,Markham PM,Spognardi A,Wong G,Fuimaono K,Böhm M,Edelman ER

    更新日期：2014-09-16 00:00:00

  • Thoracoscopic extracardiac obliteration of the left atrial appendage for stroke risk reduction in atrial fibrillation.

    abstract：OBJECTIVES:We evaluated left atrial appendage obliteration in high-risk patients with atrial fibrillation (AF). BACKGROUND:Left atrial appendage thrombosis and embolization is the principal mechanism of stroke in AF. Anticoagulation is underutilized and often contraindicated. METHODS:Thoracoscopic Left Appendage, Tot...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0735-1097(03)00953-7

    authors： Blackshear JL,Johnson WD,Odell JA,Baker VS,Howard M,Pearce L,Stone C,Packer DL,Schaff HV

    更新日期：2003-10-01 00:00:00

  • Poor R wave progression in the precordial leads: clinical implications for the diagnosis of myocardial infarction.

    abstract：:A definite diagnosis of anterior myocardial infarction is often difficult to make in patients when a pattern of poor R wave progression in the precordial leads is present on the electrocardiogram. The purpose of this study was to determine whether a mathematical model could be devised to identify patients with anterio...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(83)80332-5

    authors： DePace NL,Colby J,Hakki AH,Manno B,Horowitz LN,Iskandrian AS

    更新日期：1983-12-01 00:00:00

  • High telomerase activity in neutrophils from unstable coronary plaques.

    abstract：OBJECTIVES:We evaluated telomerase activity in circulating polymorphonuclear neutrophils (PMN) and in PMN isolated from coronary atherosclerotic plaques by a novel approach. BACKGROUND:Delayed apoptosis of PMN have been demonstrated in unstable angina (UA). These cells have a finite lifespan with low telomerase activi...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.08.048

    authors： Narducci ML,Grasselli A,Biasucci LM,Farsetti A,Mulè A,Liuzzo G,La Torre G,Niccoli G,Mongiardo R,Pontecorvi A,Crea F

    更新日期：2007-12-18 00:00:00

  • Anterior leaflet procedures during mitral valve repair do not adversely influence long-term outcome.

    abstract：OBJECTIVES:This study was done to assess the impact of anterior mitral leaflet reconstructive procedures on initial and long-term results of mitral valve repair. BACKGROUND:It has been suggested that involvement of the anterior leaflet in mitral valve disease adversely affects the long-term outcome of mitral valve rep...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(94)00325-k

    authors： Grossi EA,Galloway AC,LeBoutillier M 3rd,Steinberg B,Baumann FG,Delianides J,Spencer FC,Colvin SB

    更新日期：1995-01-01 00:00:00

  • A diagnosis of the metabolic syndrome in youth that resolves by adult life is associated with a normalization of high carotid intima-media thickness and type 2 diabetes mellitus risk: the Bogalusa heart and cardiovascular risk in young Finns studies.

    abstract：OBJECTIVES:The aim of this study was to examine the effect of resolution from metabolic syndrome (MetS) between youth and adulthood on carotid artery intima-media thickness (IMT) and type 2 diabetes mellitus (T2DM). BACKGROUND:Published findings demonstrate that youth with MetS are at increased risk of cardio-metaboli...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2012.05.056

    authors： Magnussen CG,Koskinen J,Juonala M,Chen W,Srinivasan SR,Sabin MA,Thomson R,Schmidt MD,Nguyen QM,Xu JH,Skilton MR,Kähönen M,Laitinen T,Taittonen L,Lehtimäki T,Rönnemaa T,Viikari JS,Berenson GS,Raitakari OT

    更新日期：2012-10-23 00:00:00

  • The QT interval is associated with incident cardiovascular events: the MESA study.

    abstract：BACKGROUND:Prolonged heart rate-corrected QT interval on electrocardiograms (ECGs) is associated with increased risk of myocardial infarction and cardiovascular disease (CVD)-related deaths in patients with prevalent coronary heart disease. OBJECTIVES:This study sought to examine the prognostic association between the...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2014.08.039

    authors： Beinart R,Zhang Y,Lima JA,Bluemke DA,Soliman EZ,Heckbert SR,Post WS,Guallar E,Nazarian S

    更新日期：2014-11-18 00:00:00

  • From Focal Lipid Storage to Systemic Inflammation: JACC Review Topic of the Week.

    abstract：:Concepts of atherogenesis have evolved considerably with time. Early animal experiments showed that a cholesterol-rich diet could induce fatty lesion formation in arteries. The elucidation of lipoprotein metabolism ultimately led to demonstrating the clinical benefits of lipid lowering. The view of atheromata as bland...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2019.07.061

    authors： Libby P,Hansson GK

    更新日期：2019-09-24 00:00:00

  • Apolipoprotein E genotype: epsilon32 women are protected while epsilon43 and epsilon44 men are susceptible to ischemic heart disease: the Copenhagen City Heart Study.

    abstract：OBJECTIVES:We tested the hypothesis that risk of ischemic heart disease (IHD) differs as a function of apolipoprotein E (APOE) genotype in women and men. BACKGROUND:Apolipoprotein E genotype influences lipids and lipoproteins and, therefore, possibly the risk of IHD. METHODS:We genotyped 9,241 white women and men fro...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(00)00520-9

    authors： Frikke-Schmidt R,Tybjaerg-Hansen A,Steffensen R,Jensen G,Nordestgaard BG

    更新日期：2000-04-01 00:00:00

  • Quantification of renal blood flow with contrast-enhanced ultrasound.

    abstract：OBJECTIVES:The goal of this study was to determine the ability of contrast-enhanced ultrasound (CEU) to quantify renal tissue perfusion. BACKGROUND:The kinetics of tracers used to assess renal perfusion are often complicated by countercurrent exchange, tubular transport or glomerular filtration. We hypothesized that, ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(00)01210-9

    authors： Wei K,Le E,Bin JP,Coggins M,Thorpe J,Kaul S

    更新日期：2001-03-15 00:00:00

  • Demonstration of increased myocardial lipid with postischemic dysfunction ("myocardial stunning") by proton nuclear magnetic resonance spectroscopy.

    abstract：:Histopathologic studies have demonstrated accumulation of lipid droplets in myocardium subjected to greater than or equal to 6 h of ischemic insult. Proton nuclear magnetic resonance (NMR) spectroscopy can provide a noninvasive means to evaluate changes in tissue lipid and, potentially, to characterize the ischemic in...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(89)90620-7

    authors： Reeves RC,Evanochko WT,Canby RC,McMillin JB,Pohost GM

    更新日期：1989-03-01 00:00:00

  • Milrinone in congestive heart failure: acute and chronic hemodynamic and clinical evaluation.

    abstract：:Acute and chronic hemodynamic and clinical responses to milrinone, a new oral inotrope-vasodilator agent, were evaluated prospectively in 37 patients with severe congestive heart failure. The majority of patients (n = 31) had not responded to prior vasodilator therapy, with a substantial number (n = 8) requiring intra...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80185-6

    authors： Simonton CA,Chatterjee K,Cody RJ,Kubo SH,Leonard D,Daly P,Rutman H

    更新日期：1985-08-01 00:00:00

  • Lysis of plasminogen activator-resistant platelet-rich coronary artery thrombus with combined bolus injection of recombinant tissue-type plasminogen activator and antiplatelet GPIIb/IIIa antibody.

    abstract：:Resistance of coronary occlusive thrombus to thrombolytic therapy, found in some patients with acute myocardial infarction, may be due to the presence of platelet-rich coronary clot. Reperfusion therapy in such patients may require the development and evaluation of alternative strategies in animal models. Therefore, p...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(90)90327-l

    authors： Yasuda T,Gold HK,Leinbach RC,Saito T,Guerrero JL,Jang IK,Holt R,Fallon JT,Collen D

    更新日期：1990-12-01 00:00:00

  • External Aortic Root Support to Prevent Aortic Dilatation in Patients With Marfan Syndrome.

    abstract：BACKGROUND:Personalized external aortic root support (PEARS) was introduced in 2004 for prevention of aortic root dilatation in Marfan patients. The individual's aortic root is replicated by 3-dimensional printing. A polymer mesh sleeve is manufactured, which is implanted with the aim to support and stabilize the aorti...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2018.06.053

    authors： Izgi C,Newsome S,Alpendurada F,Nyktari E,Boutsikou M,Pepper J,Treasure T,Mohiaddin R

    更新日期：2018-09-04 00:00:00