Trends in nalidixic acid resistance in nontyphoidal Salmonella isolated from 1999 to 2002: decreased susceptibility to 6 fluoroquinolones.

Abstract:

:We determined the resistance to nalidixic acid and 6 fluoroquinolones of 771 nontyphoidal Salmonella strains isolated from humans between 1999 and 2002. A total of 22 different serotypes were identified among the Salmonella isolates, the most common being Salmonella Enteritidis (79%) and Salmonella Derby (8%). Resistance to nalidixic acid increased from 38% in 1999 to 43% in 2002. This resistance was not homogeneous among the different serotypes, with the highest percentage of resistant isolates belonging to Salmonella Hadar (79%) followed by Salmonella Enteritidis (46%). Reduced ciprofloxacin susceptibility (minimal inhibitory concentrations [MICs] from 0.12 to 0.5 microg/mL) was observed in 300 (39%) Salmonella. In our study, the nalidixic acid-resistant strains had an MIC90 at least 4-fold higher than the susceptible ones for all the fluoroquinolones tested, thus showing that resistance to nalidixic acid is an indicator of low-level resistance to all fluoroquinolones.

authors

Rodriguez-Avial I,Rodriguez-Avial C,López O,Picazo JJ

doi

10.1016/j.diagmicrobio.2005.02.013

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

261-4

issue

3

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(05)00052-0

journal_volume

52

pub_type

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