当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Intracoronary ultrasound assessment late after the arterial switch operation for transposition of the great arteries.

Intracoronary ultrasound assessment late after the arterial switch operation for transposition of the great arteries.

Abstract：

OBJECTIVES:This research was undertaken to assess the status of the coronary wall morphology late after the arterial switch operation (ASO) for transposition of the great arteries employing intravascular ultrasound (IVUS). BACKGROUND:Long-term patency of the reimplanted coronary arteries is a key issue after ASO. Follow-up studies have demonstrated coronary obstruction in up to 8% of patients that may be related to progressive fibrocellular intimal thickening. METHODS:Twenty-two asymptomatic children were enrolled at a median age of 9.5 years (range 5 to 22 years); IVUS images were obtained in 20 children at cardiac catheterization 5.0 to 21.6 years after the operation (in two cases IVUS study was not feasible due to technical constraints). Quantitative analysis was performed in 37 coronary arteries involving segments with a mean length of 28.4 +/- 1.8 mm. RESULTS:Thirty-three arteries (89%) displayed variable degrees of proximal eccentric intimal proliferation, with the maximal intimal thickening being 0.26 +/- 0.14 mm (range 0.06 to 0.71 mm) at the most thickened site. According to the Stanford classification, all children had coronary artery involvement with 50% having moderate-to-severe lesions (>0.3 mm). No risk factors for such abnormalities were encountered, including age, origin of the coronary arteries, hemodynamics, and follow-up duration after surgery. CONCLUSIONS:Intravascular ultrasound assessment late after the ASO revealed proximal eccentric intimal thickening in most of the studied vessels. This observation suggests the development of early atherosclerosis in the reimplanted coronary arteries, which may have a role in the genesis of late coronary events.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Pedra SR,Pedra CA,Abizaid AA,Braga SL,Staico R,Arrieta R,Costa JR Jr,Vaz VD,Fontes VF,Sousa JE

doi

10.1016/j.jacc.2005.02.076

subject

Has Abstract

pub_date

2005-06-21 00:00:00

pages

2061-8

issue

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(05)00682-0

journal_volume

pub_type

杂志文章

在线工具

Intracoronary ultrasound assessment late after the arterial switch operation for transposition of the great arteries.