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Late stent recoil of the bioabsorbable everolimus-eluting coronary stent and its relationship with plaque morphology.

Abstract：

OBJECTIVES:This study sought to evaluate late recoil of a novel bioabsorbable everolimus-eluting coronary stent (BVS), which is composed of a poly-L-lactic acid backbone, coated with a bioabsorbable polymer containing everolimus. BACKGROUND:Little is known about the mechanical behavior of bioabsorbable polymer stents after deployment in diseased human coronary arteries. METHODS:The study population consisted of 16 patients, who were treated with elective BVS implantation for single de novo native coronary artery lesions and were followed at 6 months. All patients underwent an intravascular ultrasound examination at post-procedure and follow-up. A total of 484 paired cross-sectional areas (CSAs) were acquired and analyzed. Late absolute stent recoil was defined as stent area at post-procedure (X) - stent area at follow-up (Y). Late percent stent recoil was defined as (X - Y)/X x 100. In each CSA, plaque morphology was assessed qualitatively and classified as calcific, fibronecrotic, or fibrocellular plaque. RESULTS:Late absolute and percent recoil of the BVS was 0.65 +/- 1.71 mm(2) (95% confidence interval [CI]: 0.49 to 0.80 mm(2)) and 7.60 +/- 23.3% (95% CI: 5.52% to 9.68%). Calcified plaques resulted in significantly less late recoil (0.20 +/- 1.54 mm(2) and 1.97 +/- 22.2%) than fibronecrotic plaques (1.03 +/- 2.12 mm(2) and 12.4 +/- 28.0%, p = 0.001 and p = 0.001, respectively) or fibrocellular plaque (0.74 +/- 1.48 mm(2) and 8.90 +/- 19.8%, p = 0.001 and p = 0.001, respectively). CONCLUSIONS:The BVS shrank in size during the follow-up period. The lesion morphology of stented segments might affect the degree of late recoil of the BVS. (ABSORB Everolimus Eluting Coronary Stent System First in Man Clinical Investigation; NCT00300131).

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Tanimoto S,Bruining N,van Domburg RT,Rotger D,Radeva P,Ligthart JM,Serruys PW

doi

10.1016/j.jacc.2008.08.024

subject

Has Abstract

pub_date

2008-11-11 00:00:00

pages

1616-20

issue

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(08)02882-9

journal_volume

pub_type

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Late stent recoil of the bioabsorbable everolimus-eluting coronary stent and its relationship with plaque morphology.