Abstract：
:Treatment of patients with small-cell lung cancer (SCLC) remains disappointing despite high initial complete response rates. The dramatic initial chemosensitivity of tumor cells is frustrated by the early emergence of chemoresistant clonogenic cells, regardless of front line treatments. Although the dose relationship is fairly well established regarding the response rate, its effect on survival is inconclusive. From 1980 to 1988, 202 patients with limited SCLC were included in four consecutive protocols using an alternating schedule of thoracic radiotherapy and chemotherapy. Despite an increase of chemotherapy and/or total radiation doses, no significant difference was observed between the four protocols in terms of response rate, disease free and overall survival. However, a retrospective analysis performed on a total of 131 consecutive patients led us to propose the hypothesis that a moderate increase in the initial dose, ie first course, of cisplatin and cyclophosphamide could improve overall survival. From 1988 to 1991, 105 patients were subsequently included in a large randomized trial raising this question. The treatment difference only concerned the initial doses of cisplatin (80 vs 100 mg/m2) and cyclophosphamide (900 vs 1200 mg/m2). The trial was closed after inclusion of 105 patients, 32 months after the start of the study because at that time overall survival was significantly better in the higher-dose group (p = 0.001). The emergence of this debatable concept opens new directions in the therapeutic strategy of SCLC and the contribution of hematopoietic growth factors may be of great interest in the management of this disease.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Le Chevalier T,Le Cesne A,Arriagada Rsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
24s-28seissn
0007-4551issn
1769-6917journal_volume
82 Suppl 1pub_type
临床试验,杂志文章,meta分析,随机对照试验abstract：:For some years, the concept of stress has been accepted as a reference framework for the study of disturbances of psychological adjustment to cancer. Stress is defined as a state of physiological and psychological < tension > resulting from the interaction between an individual and her environment. Damaging consequenc...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2007-05-01 00:00:00
abstract：:With a minimum follow-up period of 10 years, the incidence of sequelae after loco-regional treatment of 349 breast cancers remains low, being dominated by lymphoedema. Rare after treatment by irradiation alone, lymphoedema appears more frequently in patients treated by radio-surgical association, in spite of a moderat...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Rapamycin (sirolimus) is a macrolide, related to cyclosporine with immunosuppressive properties and antiproliferative activity in various human tumor cells lines and tumor xenograft models. The cytosolic kinase mTOR which controls the initiation of the translation of messenger RNA is the main known target of rapamycin...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
abstract：INTRODUCTION:An in-patient clinical service has been set up in March 2016 in the Occupational Diseases Center of Brest University Hospital, France, to seek for work-relatedness of diseases in patients hospitalized into the oncology and hematology departments. We present here data after two years of existence. METHODS:...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2020.01.013
更新日期：2020-04-01 00:00:00
abstract：:Paclitaxel is often used as an adjuvant antineoplastic agent. However, very little data is available in literature on its potential genotoxicity on healthy human cells. Our objective is to study the potential in vitro genotoxicity of paclitaxel, by using the cytokinesis-blocked micronucleus assay in combination with f...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：:Cancerogenesis is believed to be a multistep process composed of different alterations that drive the transformation of normal human cells into highly malignant derivatives. These changes include self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, the evasion of programmed cell death, a lim...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2008.0600
更新日期：2008-03-01 00:00:00
abstract：:Lung and head and neck cancers result from a multistep process involving activation of oncogenes and inactivation of tumor-suppressor genes. These two processes share common features and molecular players, while their corresponding clinical entities are both triggered by the tobacco carcinogens. In many cases, the mol...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2009.0786
更新日期：2009-01-01 00:00:00
abstract：:Apparition of new tools in the therapy of multiple (MM) strengthens the need for valuable prognostic categorization of each patient in order to propose the most adequate treatment. Prognostic factors in MM can be divided in four groups. The first, including beta 2 microglobulin (beta 2m), hemopoiesis impairment, osteo...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:The effects various drugs exert on antioxidant enzyme and glyoxalase activity in rat livers were studied. All drugs tested provoked a marked reduction in glutathione peroxidase and a small drop in both glyoxalase I and II activity. It is hypothesized that the substances tested support tumour development by neutralizin...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Cardiac neoplasms are a rare occurrence in clinical practice. The various frequencies of primary and secondary malignant tumors vary from report to report, approximately 1% in most autopsy series and 4% in cancer patient's autopsies. Cardiac malignancies account for less 1% of cardiac surgery and about for 0.1% of car...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：:A nonfusing variant M4 of the L6 line of rat myoblasts was isolated. This subline was tumorigenic when inoculated into suckling rats. Comparative studies of cells growth in vitro, serum requirement, cell adhesiveness and capacity to form colonies in soft agar confirmed that M4 cells had undergone neoplastic transforma...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Originally described for its capacity to induce hemorrhagic necrosis of transplantable tumors in mice, TNF-alpha also exerts cytotoxic effects against some tumor cell lines in vitro. It is now known that TNF is an essential mediator of cellular immunity and a wide variety of biological activities of TNF in vitro and i...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:Since the first published correlations around the years 1975 between estrogen and progesterone receptors and response to hormone therapy, numerous data have modified our insight on hormone dependency. For instance, it is now well established that tumors are not "receptor positive" or "receptor negative" but contain va...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVE:To assess the feasibility and efficacy of cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) without adjuvant chemotherapy for relapsed or persistent advanced ovarian cancer. METHODS:This observational study included stage IIIC ovarian cancer patients due to undergo CRS...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2010.1063
更新日期：2010-04-01 00:00:00
abstract：:Advanced stage follicular lymphoma is incurable by conventional treatment. Important progress has been observed with the development of new therapies based on monoclonal antibodies and on the use of radioimmunotherapy (RIT) in the treatment of non-Hodgkin lymphomas (NHL). Rituximab in combination with chemotherapy in ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2007-09-01 00:00:00
abstract：:Chemotherapy-induced peripheral neuropathy (CIPN) is common with specific semiological characteristics. When CIPN appears, there are many difficulties in guaranteeing sustained treatment, especially with optimal protocol. Moreover, CIPN have bad repercussions on quality of life after cancer disease. In this article, w...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2018.07.009
更新日期：2018-11-01 00:00:00
abstract：:The treatment of the advanced ovarian adenocarcinoma, most frequently stage at diagnostic, relies on association of surgery and chemotherapy. The current standard is the association carboplatine-paclitaxel. In spite of this treatment, relapses are frequent, and the prognosis thus remains very reserved. Presently the c...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2009.0987
更新日期：2009-12-01 00:00:00
abstract：:For two decades, the prognostic of adult patients with ALL was improved based on pediatric-inspired protocols. These approaches based on less myelosuppressive drugs have led to improved response rates, decreased relapse rates, with a benefit in survival observed in patients aged up to 50-60-years-old. Therapeutic inte...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2020.07.008
更新日期：2020-09-24 00:00:00
abstract：:Breast cancer remains a potentially lethal disease, which requires aggressive treatments and is associated with long-term consequences. Its prognosis is linked to both tumor biology and burden at diagnosis. Although treatments have allowed important improvements in prognosis over the past 20 years, breast cancer scree...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2016.06.005
更新日期：2016-09-01 00:00:00
abstract：AIM:Harvesting of the "sentinel lymph node" (SLN) as identified by lymphoscintigraphy (LSG) is becoming increasingly important in the staging of patients with malignant melanoma. The purpose of the current study was to determine whether the appearance time of the LSG had a prognostic value in predicting metastasis diss...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:Stereotactic radiation therapy, consisting in irradiating the tumor with a high dose per fraction, has a therapeutic potential because of excellent local control. This technique requires a high accuracy level in order to minimize the risk of normal tissue toxicity. Initially used for cerebral localization, the stereot...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1144
更新日期：2010-07-01 00:00:00
abstract：:Between October 1987 and June 1992, 244 patients with metastatic renal carcinoma were referred to our Institute. One hundred and sixty-nine were included in immunotherapy protocols. The 40 most recent patients were included in the ongoing multicentric randomised Crecy study. The previous patients were treated with IL2...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-07-01 00:00:00
abstract：:Urothelial tumors are very rare in children (to date, only about 150 cases have been reported worlwide). Only 20% occur before the age of ten. The aim of this study is to specify the clinicopathologic features of urothelial tumor in young patients, which require a slightly different approach to treatment. On the basis...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2016.11.018
更新日期：2017-02-01 00:00:00
abstract：:Immunotherapy alone or in combination with chemotherapy is now an integral part of the treatment of metastatic NSCLC. This treatment is transforming the management of these cancers, with 20-30% of patients achieving long survival. However, disease progression under treatment is still the rule for the majority of patie...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2020.04.018
更新日期：2020-01-01 00:00:00
abstract：:Testicle germ cells tumors are the most common young men neoplasm. The incidence is maximal in Scandinavian countries. Cryptorchidism is a predisposing factor. Diagnosis is clinic, first treatment is radical orchidectomy by inguinal incision, after study of tumor markers. Histology shows seminoma or non seminomatous t...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
abstract：:Chemotherapy has dramatically improved the prognosis of non-seminomatous germ cell tumors (NSGCT). However, some patients relapse and others are refractory to first line chemotherapy. We studied a salvage chemotherapeutic regimen with etoposide 75 gm/m2/day, and cisplatin 40 mg/m2/day, days 1-5 and Ifosfamide 3 g/m2/d...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Colorectal primary signet ring cell carcinoma (SRCC) is a rare entity accounting for nearly 1% of all colorectal carcinomas. It is an independent prognostic factor associated with less favorable outcome. This aggressiveness is mainly due to the intrinsic biology of these tumors. Here is an overview of the literature r...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2015.07.005
更新日期：2015-10-01 00:00:00
abstract：:Cell signalling represents the network of cell communication pathways. Reception of a message by a cell results in the implementation of various direct and indirect actions, especially through the transcription of the genes required for carrying out the orders received. The signals exchanged by cells may concern proli...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1199
更新日期：2010-11-01 00:00:00
abstract：SURGICAL DE-ESCALATION FOR INVASIVE BREAST CANCER TREATMENT:A surgical therapeutic de-escalation is going to continue but necessarily has to design in a progressive careful way and especially arranged with the other practitioners and therapeutic methods. These strategies concern as well the surgery of the breast as tha...
journal_title：Bulletin du cancer
pub_type： 社论
doi：10.1016/S0007-4551(16)30151-5
更新日期：2016-06-01 00:00:00
abstract：:Six cell lines originated from foetal mouse brain were maintained in vitro for more than two years. The morphology of most of these cultures suggests their glial character. This is corroborated, for some lines, by the presence of specific glial protein (Glial fibrillary acidic protein, or GFAP). Five out of these line...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
