Abstract：
:Noise, partial volume (PV) effect, and image-intensity inhomogeneity render a challenging task for segmentation of brain magnetic resonance (MR) images. Most of the current MR image segmentation methods focus on only one or two of the above-mentioned effects. The objective of this paper is to propose a unified framework, based on the maximum a posteriori probability principle, by taking all these effects into account simultaneously in order to improve image segmentation performance. Instead of labeling each image voxel with a unique tissue type, the percentage of each voxel belonging to different tissues, which we call a mixture, is considered to address the PV effect. A Markov random field model is used to describe the noise effect by considering the nearby spatial information of the tissue mixture. The inhomogeneity effect is modeled as a bias field characterized by a zero mean Gaussian prior probability. The well-known fuzzy C-mean model is extended to define the likelihood function of the observed image. This framework reduces theoretically, under some assumptions, to the adaptive fuzzy C-mean (AFCM) algorithm proposed by Pham and Prince. Digital phantom and real clinical MR images were used to test the proposed framework. Improved performance over the AFCM algorithm was observed in a clinical environment where the inhomogeneity, noise level, and PV effect are commonly encountered.
journal_name
Med Physjournal_title
Medical physicsauthors
Li X,Li L,Lu H,Liang Zdoi
10.1118/1.1944912subject
Has Abstractpub_date
2005-07-01 00:00:00pages
2337-45issue
7eissn
0094-2405issn
2473-4209journal_volume
32pub_type
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