Imaging maculopathy in post-mortem human eyes.

Abstract:

:Age-related maculopathy (ARM) remains a poorly understood degeneration. To discover new pathways using contemporary genomics, proteomics, and immunohistochemistry, validate emerging animal models, and validate new imaging modalities, human tissues obtained from donor eyes will be essential to ARM research for the foreseeable future. Because fundus appearance is the clinical diagnostic lingua franca, laboratory investigators adapted these standards to the distinctive appearance of post-mortem tissues in order to identify and stage ARM in donor eyes. Post-mortem tissues offer unique advantages and limitations relative to pre-mortem tissues for imaging studies. One fellow eye can be used for imaging and the other for correlative laboratory studies, if some degree of disease stage asymmetry between eyes is acceptable. Histological verification is a necessary, albeit challenging, step in validating a grading system.

journal_name

Vision Res

journal_title

Vision research

authors

Curcio CA

doi

10.1016/j.visres.2005.07.038

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

3496-503

issue

28

eissn

0042-6989

issn

1878-5646

pii

S0042-6989(05)00397-4

journal_volume

45

pub_type

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