Abstract:
:Age-related maculopathy (ARM) remains a poorly understood degeneration. To discover new pathways using contemporary genomics, proteomics, and immunohistochemistry, validate emerging animal models, and validate new imaging modalities, human tissues obtained from donor eyes will be essential to ARM research for the foreseeable future. Because fundus appearance is the clinical diagnostic lingua franca, laboratory investigators adapted these standards to the distinctive appearance of post-mortem tissues in order to identify and stage ARM in donor eyes. Post-mortem tissues offer unique advantages and limitations relative to pre-mortem tissues for imaging studies. One fellow eye can be used for imaging and the other for correlative laboratory studies, if some degree of disease stage asymmetry between eyes is acceptable. Histological verification is a necessary, albeit challenging, step in validating a grading system.
journal_name
Vision Resjournal_title
Vision researchauthors
Curcio CAdoi
10.1016/j.visres.2005.07.038subject
Has Abstractpub_date
2005-12-01 00:00:00pages
3496-503issue
28eissn
0042-6989issn
1878-5646pii
S0042-6989(05)00397-4journal_volume
45pub_type
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