Abstract：
AIM:To compare hypotensive and antiischemic efficacy of enalapril combination with trimetazidine or placebo, effects on plasmic lipid spectrum and membrane-cell parameters of erythrocytes and platelets in hypertensive patients with ischemic heart disease (IHD) in the presence of metabolic disturbances. MATERIAL AND METHODS:A randomized placebo-controlled comparative trial included 64 patients (mean age 55.60 +/- 0.52 years) with hypertension stage I-III, IHD (stable effort angina FC II-III, obesity of the first-third degree, diabetes mellitus type 2. The patients were divided into two groups matched by gender, age, duration of the disease, office blood pressure (OBP), functional class (FC) of effort angina, body mass index, glucose levels in the blood. 43 patients of group 1 received enalapril and trimetazidine. 21 patients of group 2 were treated with enalapril and placebo. The efficacy of the treatment was assessed by changes in the 24-h profile of BP and ECG, blood lipid spectrum and membrane-cell parameters. RESULTS:A significant fall was seen in systolic blood pressure of both groups patients. In group 1 there was an additional lowering of temporal index of systolic pressure, nocturnal diastolic, mean 24-h diastolic, mean 24-h blood pressure, double product of ischemic episodes, total cholesterol, dienic conjugates in platelets. Catalase activity in erythrocytes rose. CONCLUSION:An antiischemic effect of the therapy in stabilization of blood pressure, normalization of plasmic lipids and lipoperoxidase in erythrocytic and platelet membranes under multidirectional correlations between clinical and biochemical parameters point to different mechanisms of ischemic correction in enalapril and trimetazidine.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Petelina TI,Gapon LI,Bakhmatova IuA,Zhevagina IAsubject
Has Abstractpub_date
2005-01-01 00:00:00pages
19-23issue
8eissn
0040-3660issn
2309-5342journal_volume
77pub_type
临床试验,杂志文章,随机对照试验abstract：:Altogether 216 patients with grave infection-dependent (49.5%) and autoimmune (50.5%) bronchial asthma received 311 courses of immunosuppressant therapy, with follow up periods up to 8 years. According to the clinico-immunologic data the patients were distributed into 4 groups. The basic drugs were (1) azathioprin, (2...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：AIM:To examine structural and electrophysiological predictors of the onset and establishment as chronic of cardiac fibrillation (CF). MATERIAL AND METHODS:Echocardiography, transesophageal electrophysiological examination of the heart were performed in 420 cases of paroxysmal cardiac fibrillation (PCF). They were diag...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：AIM:To assess orthogonal ECG system McFee-Parungao in exercise test performed by patients with ischemic heart disease (IHD). MATERIAL AND METHODS:The trial included 103 patients: 41 patients with IHD, 23 patients with IHD combined with arterial hypertension and 39 control patients free of IHD. All the patients perform...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:The hypotensive and diuretic properties of heparin were evaluated in 95 patients with different clinical and morphological varieties of chronic glomerulonephritis (CGN). The arterial blood pressure dropped in all the patients treated with heparin. The maximal effect was attained toward the end of heparin treatment (by...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：AIM:To evaluate the efficiency and safety of intravenous infusion of levosimendan in patients with idiopathic pulmonary hypertension (IPH) and its clinical, hemodynamic, and neurohumoral effects. SUBJECTS AND METHODS:The study included 9 patients (mean age 31.8 +/- 8.7 years) with Functional Class III and IV IPH and s...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:The authors relate the results of a clinico-morpho-instrumental analysis of the clinical course of lymphosarcomas in 38 patients with different morphological patterns of the disease with primary injury to the spleen. The patients received multimodality therapy including splenectomy. It has been established that later ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The paper is concerned with observation over 470 patients with systemic lupus erythematosus (SLE) admitted to the Institute of Rheumatology, Academy of Medical Sciences of the USSR, since December 1958 to December 1983. Women (453) with a disease onset at 10 to 55 years (355 had associated SLE and nephritis, 155 prese...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：AIM:To study left ventricular structural and functional changes in patients with chronic obstructive pulmonary disease (COPD) and chronic cor pulmonale (CCP) at different stages of a cardiac remodeling process. SUBJECTS AND METHODS:Echocardiography was used to examine 98 patients with COPD complicated by the developme...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：AIM:to evaluate brachial artery (BA) endothelial vasomotor function in patients with systemic lupus erythematosus (SLE) and scleroderma systematica (SDS), by using noninvasive studies. Subjects and methods. Sixty-five patients, including 25 with SLE, 20 with SDS, and 20 with atherosclerosis (AS) obliterans of lower ext...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：AIM:To study effectiveness and tolerance of monoclonal antibodies to tumor necrosis factor (the drug remicade) in patients with rheumatoid arthritis (RA). MATERIAL AND METHODS:Remicade treatment results are considered for 25 RA patients receiving methotrexate the activity of which was inadequate for these patients. Re...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：AIM:To study therapeutic potential of a novel basic drug leflunomide in suppression of activity and progression of rheumatoid arthritis (RA). MATERIAL AND METHODS:Leflunomide efficacy was investigated in a 36 month trial including 50 patients with moderate and high activity RA. Monthly registrations were made of the a...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Prospects of introduction of personification medicine principles into clinical nephrology are discussed with a special emphasis on prognosis of the course of chronic kidney diseases and response of the latter to pathogenetic therapy. ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：AIM:To detect the most common clinical manifestations of Legionella pneumonia (LP) in immunocompromized patients. SUBJECTS AND METHODS:Clinical manifestations, the results of investigation of bronchoalveolar lavage fluid (BALF) and urine, and the data of lung computed tomography (CT) were studied in patients with bloo...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：AIM:To compare efficacy of basic RA treatment with methotrexate+plaquenil and basic monotherapy with methotrexate. MATERIAL AND METHODS:Two groups of rheumatoid arthritis (RA) patients were studied: group 1 (n = 82) received combined basic treatment with methotrexate (7.5 mg/week) in combination with plaquenil (0.2 ?m...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:Seventy patients with pectus carinatum were examined. All the patients demonstrated the minimal signs of connective tissue deficiency. The ECG readings showed incomplete blockade of the bundle of His, ventricular extrasystole, WPW and CLC syndromes, and metabolic alterations in the myocardium. Mitral valve prolapse wa...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：AIM:To describe some clinical variants of hypochondriac syndrome in patients with duodenal ulcer (DU). MATERIAL AND METHODS:A hypochondriac trend was studied clinically and was confirmed by changes in the first scale of AMPI in 150 DU patients. If the first scale contained a rise over 70 points, the examinee was state...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:The review considers modern ideas about the clinic and pathogenesis of minimal hepatic encephalopathy (MHE). It is discussed the present of cognitive impairment in this category of patients. The data of functional MRI are analyzed, and these results allow taking a fresh look at the origin of clinical disorders in this...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：10.26442/terarkh201890289-93
更新日期：2018-02-15 00:00:00
abstract：:The authors present pilot experience in extracorporeal blood purification (hemosorption, plasmapheresis) aimed at correction of cardiac arrhythmia. Seven responders of 8 patients treated had less frequent episodes of cardiac fibrillation the severity of which decreased, they suffered no more from high-grade extrasysto...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：AIM:To determine clinical significance of high concentrations of homocystein, C-reactive protein, fibrinogen in various forms of ischemic heart disease. MATERIAL AND METHODS:Enzyme immunoassay was made to measure serum concentrations of homocystein, C-reactive protein, fibrinogen in 60 patients with ischemic heart dis...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Altogether 33 patients with arterial hypertension were investigated to study changes of left ventricular systolic phasic analysis, caused by prazosin therapy. Two groups were identified on the basis of these changes: indices in the 1st group (intrasystolic index, myocardial tension index, Blumberger coefficient) impro...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：AIM:To estimate the time course of changes in brachial artery (BA) functional parameters in patients with unstable angina (UA) treated with angiotensin-converting enzyme inhibitors. SUBJECTS AND METHODS:After examination, 30 patients with Braunwald Classes IB and IIB UA were randomized to two groups to receive perindo...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2012-01-01 00:00:00
abstract：:A study was made of the survival time of erythrocytes labeled with 51Cr in 30 patients with hypoplastic anemia. In 96.7% of the patients erythrocyte survival time was reduced (from 18 to 3.6 days; an average of 11.8 days), an increase in the number of macrocytes was noted (in 83.3%). The mean volume and thickness of e...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：AIM:To estimate the distribution of HLA Class I (A, B) antigens in patients with Behcet's disease (BD) and the association of HLA-B5 antigen with the clinical manifestations of the disease in different ethnic and population groups in relation to gender. SUBJECTS AND METHODS:The study covered 93 patients (68 males, 25 ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：AIM:To investigate the link between the hypoglycemia (registrated accurately by the professional Continuous Glucose Monitoring CGM; severe hypoglycemia at home) and the hetero-/homozygote carriage of single nucleotide polymorphisms (SNP) of cytochrome systems geneCYP2C9(rs1799853CYP2C9*2 иrs1057910CYP2C9*3) at the pati...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.26442/00403660.2020.10.000530
更新日期：2020-11-24 00:00:00
abstract：:The authors studied the economic efficacy of 5-year follow-up and treatment of AH patients at the population level. An opportunity of a considerable decrease in AH morbidity and mortality was shown. In the intervention group all expenditures on AH control after 5-year treatment payed back 3-fold. ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：AIM:To make a comparative clinical and economic assessment of a transdermal therapeutic system (TTS) for fendivia and traditional opioid analgesics in patients with malignant neoplasms (MN) during palliative care. MATERIALS AND METHODS:Pharmacoeconomic analysis of opioid analgesics used in patients with MN during anal...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：AIM:To study antianginal effectiveness of trimetazidine (TMS) in monotherapy and combined antianginal therapy; to design approaches to prediction of its effect. MATERIAL AND METHODS:An open cross-over randomised trial enrolled 29 anginal patients. They were given a single TMS dose (60 mg) and its effect was compared t...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2000-01-01 00:00:00
abstract：:Altogether 58 patients suffering from arterial hypertension (AH) were examined. The patients with left ventricular hypertrophy (LVH) and changes in the ST-T demonstrated a high correlation between an increase of the end systolic tension (EST) and interval elongation and the minimal size of the left ventricle before mi...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The principal methods of the treatment of the hyperventilation syndrome (HVS) are reviewed. The following methods of the action on the patient are distinguished: psychotherapy, pharmacotherapy, remedial gymnastics, correction of respiratory disorders according to the principle of the biological feed-back mechanism, re...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：:The authors relate the results of 10 years of observations of 113 patients suffering from gluten enteropathy (GE) of the adults. In all the patients, the diagnosis was supported by the presence of hyper-regenerative atrophy of the small intestinal mucosa (total in 70% and subtotal in 30%). Metabolic disorders and cell...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
