Abstract：
AIM:To detect the most common clinical manifestations of Legionella pneumonia (LP) in immunocompromized patients. SUBJECTS AND METHODS:Clinical manifestations, the results of investigation of bronchoalveolar lavage fluid (BALF) and urine, and the data of lung computed tomography (CT) were studied in patients with blood system diseases and acute respiratory failure (ARF). RESULTS:The diagnosis of LP was verified in 8 (10.5%) of 76 patients with blood system diseases and ARF. The disease manifested as fever, higher concentrations of inflammatory markers (procalcitonin, fibrinogen), ARF, hypoxemia, and infiltrative lung injury. Six of the 8 patients were switched to mechanical ventilation. Lung CT showed no pathognomonic signs. Five of the 8 patients were observed to have renal dysfunction. The diagnosis of LP was made on the basis of the results of BALF examination in 7 patients and urinary antigen detection in 1. The disease was caused by Legionella pneumophila serogroup 1 in 3 patients and by L. pneumophila of other serogroups in the other patients. Therapy with respiratory fluoroquinolones was performed in 5 patients. Three patients died from progressive ARF and hypoxemia. BALF results were obtained after their death and therapy for legionellosis was not initiated. CONCLUSION:The incidence of LP is 10.5% in hematology patients. The clinical manifestations of legionellosis are nonspecific; its diagnosis requires bacteriological and/or serological evidence. Due to the high risk of death, it is reasonable to preuse respiratory fluoroquinolones or macrolides in immunocompromized patients with progressive ARF and suspected Legionella pneumonia before diagnosis.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Galstian GM,Kostina IÉ,Katrysh SA,Kliasova GA,Karpova TI,Tartakovskiĭ ISsubject
Has Abstractpub_date
2014-01-01 00:00:00pages
45-52issue
3eissn
0040-3660issn
2309-5342journal_volume
86pub_type
杂志文章abstract：UNLABELLED:AID: To investigate the role of suprasegmental (anxious disorders) and segmental vegetative disorders (dysfunction of neuromuscular transmission and cutaneous microcirculation) in pathogenesis of muscular syndrome of rheumatoid arthritis (RA). MATERIAL AND METHODS:MMPI, Beck's questionnaire, Spilberger's te...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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journal_title：Terapevticheskii arkhiv
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:The treatment schedule for disseminated breast carcinoma has been developed. It includes the use of adriamycin (30 mg/m2, days 1, 8, 15), methotrexate (30 mg/m2, day 1), 5-FU (600 mg/m2, day 8), and cyclophosphamide (400 mg/m2, day 15 i. v. by jet injection). A complete response was obtained in 50 to 56% of the patien...
journal_title：Terapevticheskii arkhiv
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doi：
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更新日期：2008-01-01 00:00:00
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pub_type： 临床试验,杂志文章
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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更新日期：2006-01-01 00:00:00
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更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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doi：
更新日期：1992-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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doi：
更新日期：1990-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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doi：
更新日期：1985-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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doi：
更新日期：1992-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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doi：
更新日期：1984-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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doi：
更新日期：1988-01-01 00:00:00
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更新日期：2004-01-01 00:00:00
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更新日期：1998-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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doi：
更新日期：2014-01-01 00:00:00
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更新日期：2008-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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更新日期：2010-01-01 00:00:00
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