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Participation of the propeptide on procathepsin D activation of human peripheral lymphocytes and neutrophils.

Abstract：

:Flow cytometry was used to test the role of the propeptide of procathepsin D in the activation of human peripheral lymphocytes and neutrophils. A selective inhibition of the activation was achieved by antibodies targeted against the propeptide. Synthetic peptide corresponding to the cathepsin D propeptide had a very similar effect as procathepsin D itself. The interaction of procathepsin D with the cells was blocked by the propeptide as monitored in experiments with fluorescently labeled procathepsin D. Our data indicate that procathepsin D activation of human neutrophils and leukocytes described earlier is mediated through the propeptide of the procathepsin D.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Vaclav V,Jana V,Martin F

doi

10.1006/abbi.1995.1466

subject

Has Abstract

pub_date

1995-09-10 00:00:00

pages

295-8

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(85)71466-X

journal_volume

322

pub_type

杂志文章

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