Abstract:
:Some endocrine disrupting chemicals (EDCs) in the environment have been shown to exert their biological effects through interference with steroidogenesis. In this study, the potential effects of four selected polychlorinated biphenyl (PCB) congeners (PCB101, PCB110, PCB126 and PCB149) as well as several of their environmentally-relevant methylsulfonyl-(MeSO(2)-) PCB metabolites (3'-MeSO(2)-CB101, 4'-MeSO(2)-CB101, 4'-MeSO(2)-CB110, 3'-MeSO(2)-CB149 and 4'-MeSO(2)-CB149) on adrenocortical steroidogenesis were evaluated by in vitro bioassay based on the human adrenocortical carcinoma H295R cell line. The PCBs included in the study represented different structures and potential mechanisms of action. Cells were exposed for 48 h to 10 microM of each PCB congener in the presence or absence of 20% (w/w) of their corresponding MeSO(2)-PCB metabolite(s). After the chemical treatments, changes in mRNA expression of 11 steroidogenic genes (CYP11A, CYP11B1, CYP11B2, CYP17, CYP19, CYP21, 3beta-HSD1, 3beta-HSD2, 17beta-HSD1, StAR and HMGR) were quantified using molecular beacon-based real-time RT-PCR. Genes coding for enzymes involved in the later or final steps of steroid production (CYP11B1, CYP11B2, CYP19, 3beta-HSD1, 3beta-HSD2 and 17beta-HSD1) were up-regulated to various extents by most PCBs. The greatest transcriptional activations (2.8-29.9-fold) were elicited by PCB110 on CYP11B1, CYP11B2, 3beta-HSD2 and CYP19, and PCB149 on CYP11B1, 3beta-HSD1 and 17beta-HSD1. Increased expression of these steroidogenic genes might ultimately lead to a change in hormonal balance through excessive production of steroid hormones including aldosterone, cortisol and estradiol. In addition, co-treatment with 3'- and 4'-MeSO(2)-PCB149 resulted in a significant decrease in PCB149-induced 3beta-HSD1 and 17beta-HSD1 expression. This result indicates that some PCB congeners and their MeSO(2)-metabolites may affect steroidogenesis via different mechanisms. Overall, these findings suggest that PCBs and PCB metabolites can affect regulation of adrenocortical steroidogenesis.
journal_name
Chemospherejournal_title
Chemosphereauthors
Xu Y,Yu RM,Zhang X,Murphy MB,Giesy JP,Lam MH,Lam PK,Wu RS,Yu Hdoi
10.1016/j.chemosphere.2005.08.013subject
Has Abstractpub_date
2006-05-01 00:00:00pages
772-84issue
5eissn
0045-6535issn
1879-1298pii
S0045-6535(05)01009-Xjournal_volume
63pub_type
杂志文章相关文献
CHEMOSPHERE文献大全abstract::Owing to the superlative properties, engineered nanomaterials (ENM) are being used in food, cosmetics, medicine, and electronics. Therefore, exogenous ENM can be housed into humans through a multitude of exposure routes, leading to compromise of the biomolecules' functionalities through structural deformations, and ev...
journal_title:Chemosphere
pub_type: 杂志文章,评审
doi:10.1016/j.chemosphere.2020.128058
更新日期:2021-01-01 00:00:00
abstract::243 surface soil samples were collected from the Yangtze River Delta (YRD) region, and the concentration distributions and compositional profiles of 27 parent PAHs (PPAHs), nitro- and oxy-derivatives (NPAHs and OPAHs), respectively, and health risk of 16 PPAHs were determined. Atmospheric samples were collected at two...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.03.057
更新日期:2017-07-01 00:00:00
abstract::Perfluorooctanoic acid (PFOA) is a dispersive persistent organic pollutant in the environment. Accumulating reports suggest that PFOA is toxic to human lymphocytes; however, the toxicological effects of PFOA on these cells remain largely unclear. In this study, ultra-performance liquid chromatography (UPLC)-based meta...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.124810
更新日期:2020-01-01 00:00:00
abstract::In humans the main route of exposure to toxic metals is through the diet, and there is therefore a clear need for this source of contamination to be minimized, particularly in food of animal origin. For this purpose, the various sources of toxic metals in livestock farming (which vary depending on the production syste...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.07.112
更新日期:2017-10-01 00:00:00
abstract::Artemisia lerchiana is a wormwood species of the Central Asian steppe regions, where it completely cover whole areas. For the first time it was possible to show through field experiments that C(1)/C(2) halocarbons (VCHCs), such as chloroform (CHL), tetrachloroethene (PER) and hexachloroethane (HEX), can be taken up by...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2006.03.039
更新日期:2006-11-01 00:00:00
abstract::Sub-individual biomarkers are sub-lethal biological responses commonly used in the assessment of wildlife exposure to environmental contaminants. In this study, we examined the activity of glutathione-s-transferase (GST) and lactate dehydrogenase (LDH), and metallothionein (MT) concentrations among captive-raised alli...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2016.04.018
更新日期:2016-07-01 00:00:00
abstract::In recent years, biochar has received a great attention due to its high application in different sectors of environment. The feasibility of biochar applications is depended on its physical and chemical properties and biochar-derived dissolved organic matter (DOM) characteristics. This study was conducted to investigat...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2016.03.016
更新日期:2016-06-01 00:00:00
abstract::Groundwater, used in this study, contaminated predominantly with aromatic compounds, was biologically treated in a fluidized-bed reactor (FBR) with immobilized cells. The aromatics were completely decomposed, while cis-1,2-dichloroethylene (cis-DCE) and trichloroethylene (TCE) were decomposed only approximately 20% an...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2004.08.060
更新日期:2005-01-01 00:00:00
abstract::Polyurethane foam - air partition coefficients (KPUF-air) for 9 polycyclic aromatic hydrocarbons (PAHs), 10 alkyl-substituted PAHs, 4 organochlorine pesticides (OCPs) and dibenzothiophene were measured as a function of temperature over the range 5 °C-35 °C, using a generator column approach. Enthalpies of PUF-to-air t...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.01.135
更新日期:2017-05-01 00:00:00
abstract::Forty sediments were analyzed for chlorobenzenes (CBs) and hexachlorobutadiene (HCBD) to investigate their pollution topography along the Kaohsiung coast, Taiwan. Maximum CB concentrations found, varied from 15.4ng/gdw for 1,2,3-TCB to 56.8ng/gdw for 1,2,4-TCB, while higher HCBD concentrations were detected among nort...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2004.11.095
更新日期:2005-03-01 00:00:00
abstract::The effects of growth-promoting hormone diethyl aminoethyl hexanoate (DA-6) and EDTA, either alone or in combination applied to original soil or lead (Pb) spiked soil on Pb phytoextraction, subcellular distribution and chemical forms in Lolium perenne were studied. EDTA addition alone significantly reduced plant bioma...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2013.09.037
更新日期:2013-11-01 00:00:00
abstract::Cyanobacteria-derived toxin microcystin-LR (MCLR) has been widely investigated in its effects on normal cells, there is little information concerning its effects on cancer cells. In the present study, the SMMC-7721 human liver cancer cell line treated with MCLR was used to investigate the change of PP2A, cytoskeleton ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2014.03.130
更新日期:2014-10-01 00:00:00
abstract::The purpose of this study was to quantify the influences of tubificid worms on the biogeochemical functioning of an infiltration system impacted by a stormwater sediment deposit. Effects of worms with stormwater sediment deposit were compared with effects of worms with two other natural sediment deposits (one low and ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2007.06.002
更新日期:2007-12-01 00:00:00
abstract::Elevated atmospheric O3 can inhibit the growth rate of various plants and increase metal content in their tissues owing to the oxidative damage, thereby affecting their phytoremediation efficiency. In this study, a series of O3 fumigation treatments were designed to evaluate the dry weight, Cd content, and transpirati...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.128940
更新日期:2021-03-01 00:00:00
abstract::With the main objective of improving the removal of nitrogen from domestic wastewater and more sustainably, a moving bed and constructed wetland (MBCW) integrated bioreactor was fabricated and evaluated with continuous and intermittent aeration operations. The hybrid system achieves average removal efficiencies up to ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.127744
更新日期:2020-12-01 00:00:00
abstract::The presence of iodide (I(-)) in water during disinfection and oxidative treatment of water is a potential health concern because of the formation of iodinated disinfection by-products (DBPs), which may be more toxic than chlorinated DBPs. The kinetics of the oxidation of I(-) by a greener oxidant, ferrate(VI) (Fe(VI)...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2015.09.091
更新日期:2016-02-01 00:00:00
abstract::Phosphorus (P) eutrophication is a major pollution problem globally, with unprecedented amount of P emanating from agricultural sources. But little is known about the optimization of soil-biochar P sorption capacity. The study objective was to determine how biochar feedstocks and pyrolysis conditions influences carbon...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.04.012
更新日期:2017-08-01 00:00:00
abstract::The presence of large amounts of Se-laden agricultural drainage sediment in the San Luis Drain, Central California, poses a serious toxic threat to wildlife in the surrounding environment. Effective management of the drainage sediment becomes a practical challenge because the sediment is polluted with high levels of S...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2005.02.033
更新日期:2005-09-01 00:00:00
abstract::The metabolic fate of 2,4-dichlorophenol (DCP) was investigated in six macrophytes representing different life forms. Salvinia natans and Lemna minor were chosen as surface-floating plants, Glyceria maxima and Mentha aquatica as emergent species and Myriophyllum spicatum and Hippuris vulgaris as submerged aquatic plan...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2004.02.017
更新日期:2004-07-01 00:00:00
abstract::Earthworms are often used as test subjects in toxicological studies, due to their ubiquitousness and sensitivity to contaminant exposure. Such testing is typically conducted using Eisenia fetida as the test subject, but continued use of E. fetida (eco) toxicology is questionable. Therefore, in this study three earthwo...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.124595
更新日期:2020-01-01 00:00:00
abstract::Domestic chickens (Gallus gallus) were used as a surrogate species for wild turkey to assess risk from environmental 2,3,7,8-TCDD exposure. Lymphocyte proliferation and CYP450 induction were assessed in adults exposed via i.m. injection, in F1 14-day old hatchlings, in F1 adults (30-weeks old), and in 14-day old hatch...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(98)00259-8
更新日期:1998-10-01 00:00:00
abstract::The various effects of hydrodynamic cavitation (HC) on algal growth inhibition were investigated. The gas-vacuolate species Microcystis aeruginosa responded differently to the gas-vacuole-negative alga Chlorella sp. When M. aeruginosa was subjected to HC, both its cell density and photosynthetic activity were subseque...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2015.05.017
更新日期:2015-10-01 00:00:00
abstract::We examined concentrations of total mercury (tHg, inorganic and methylated forms) and polychlorinated biphenyls (PCBs) in blood and milk from free-ranging Southern Beaufort-Chukchi Sea polar bears (Ursus maritimus) to assess maternal transfer of contaminants during lactation and the potential health risk to nursing yo...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2012.02.053
更新日期:2012-07-01 00:00:00
abstract::Human intervention in the global phosphorus cycle has mobilised nearly half a billion tonnes of the element from phosphate rock into the hydrosphere over the past half century. The resultant water pollution concerns have been the main driver for sustainable phosphorus use (including phosphorus recovery). However the e...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2011.02.032
更新日期:2011-08-01 00:00:00
abstract::We determined the concentrations of organochlorine pesticides and total PCBs in plasma of nestling Wood Storks (Mycteria americana) from two colonies in Georgia in 2000. Of 20 compounds analyzed for, only p,p'-DDE was quantified in reportable concentrations, ranging from <2.0-174.0 ng/g wet weight (ww). Concentrations...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2007.03.017
更新日期:2007-07-01 00:00:00
abstract::One of the most important properties of ionic liquids is their non-volatility, making them potentially "green" alternatives to volatile organic compounds. However, they are widely soluble in water, meaning that they can be released into aquatic ecosystems and so contribute to water pollution. Nevertheless, although th...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2016.04.042
更新日期:2016-07-01 00:00:00
abstract::The study was carried out from spring 1999 to spring 2001 to monitor the residue levels of organophosphorus pollutants (OPP) in aquatic environment of the drainage canal surrounding a pesticide factory at Damietta Governorate. Water, sediment, and fish samples were collected at six different seasonal periods. OPPs wer...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2005.09.019
更新日期:2006-06-01 00:00:00
abstract::Tree bark has proven to be a reliable tool for biomonitoring deposition of metals from the atmosphere. The aim of the present study was to test if bark magnetic properties can be used as a proxy of the overall metal loads of a tree bark, meaning that this approach can be used to discriminate different effects of pollu...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.12.107
更新日期:2018-03-01 00:00:00
abstract::The application of the cosolvency sorption model to predict the sorption of carboxylic acids in cosolvent systems was found to be problematic. The cause of the discrepancy was investigated by analyzing the solubility (Sm) and sorption (Km, linear sorption coefficient) of the pesticide 2,4-dichlorophenoxyacetic acid (2...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2013.12.028
更新日期:2014-05-01 00:00:00
abstract::Here we demonstrated an alternative partial reduction graphene oxide/metal-organic frameworks nano-scale laminated membrane for dyes and heavy metal ions removal at low pressure. Compared with pure prGO membranes, the novel UiO-66-(COOH)2/prGO membranes with loose structure and excellent selective permeability demonst...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.04.064
更新日期:2018-08-01 00:00:00