Abstract：
:Perfluorooctanoic acid (PFOA) is a dispersive persistent organic pollutant in the environment. Accumulating reports suggest that PFOA is toxic to human lymphocytes; however, the toxicological effects of PFOA on these cells remain largely unclear. In this study, ultra-performance liquid chromatography (UPLC)-based metabolomic analysis was employed to identify metabolites in human peripheral blood lymphocytes and to assess the metabolic alterations caused by PFOA exposure. Our comparative metabolomic analysis results demonstrated that PFOA treatment could increase the level of organic acids and reduce the level of lipid molecules. Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation further highlighted the fact that the PFOA treatment interfered with the metabolism of amino acids, carbohydrates and lipids, which may lead to disruption of the immune system.
journal_name
Chemospherejournal_title
Chemosphereauthors
Li R,Guo C,Tse WKF,Su M,Zhang X,Lai KPdoi
10.1016/j.chemosphere.2019.124810subject
Has Abstractpub_date
2020-01-01 00:00:00pages
124810eissn
0045-6535issn
1879-1298pii
S0045-6535(19)32049-1journal_volume
239pub_type
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