Abstract:
:Toxic elements exposure disturbs the homeostasis of essential elements in organisms, but the mechanism remains elusive. In this study, we demonstrated that Drosophila melanogaster exposed to Lead (Pb, a pervasive environmental threat to human health) exhibited various health defects, including retarded development, decreased survival rate, impaired mobility and reduced egg production. These phenotypes could be significantly modulated by either intervention of dietary iron levels or altering expression of genes involved in iron metabolism. Further study revealed that Pb exposure leads to systemic iron deficiency. Strikingly, reactive oxygen species (ROS) clearance significantly increased iron uptake by restoring the expression of iron metabolism genes in the midgut and subsequently attenuated Pb toxicity. This study highlights the role of ROS in Pb induced iron dyshomeostasis and provides unique insights into understanding the mechanism of Pb toxicity and suggests ideal ways to attenuate Pb toxicity by iron supplementation therapy or ROS clearance.
journal_name
Chemospherejournal_title
Chemosphereauthors
Liu ZH,Shang J,Yan L,Wei T,Xiang L,Wang HL,Cheng J,Xiao Gdoi
10.1016/j.chemosphere.2019.125428subject
Has Abstractpub_date
2020-03-01 00:00:00pages
125428eissn
0045-6535issn
1879-1298pii
S0045-6535(19)32668-2journal_volume
243pub_type
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