Abstract：
:Owing to the superlative properties, engineered nanomaterials (ENM) are being used in food, cosmetics, medicine, and electronics. Therefore, exogenous ENM can be housed into humans through a multitude of exposure routes, leading to compromise of the biomolecules' functionalities through structural deformations, and even at the metabolic level. Consequently, it is of great importance to understand the perturbations introduced at the metabolic level for the timely risk assessment (RA) of ENM. Current technological advancements in metabolomics empower us to visualize the metabolic dysregulations in biological cells, tissues, and living objects, instigated by the ENM. Given the fact, we propose multitiered untargeted metabolomics for the risk assessment of ENM. We propose largely validated experimental design principles that enable the well-organized and authentic identification of metabolic dysregulation connected with a newly engineered nanomaterial. Our scheme could participate in the enhanced transparency of the RA course of rapidly emerging ENM.
journal_name
Chemospherejournal_title
Chemosphereauthors
Ahmad F,Abubshait SA,Abubshait HAdoi
10.1016/j.chemosphere.2020.128058subject
Has Abstractpub_date
2021-01-01 00:00:00pages
128058eissn
0045-6535issn
1879-1298pii
S0045-6535(20)32253-0journal_volume
262pub_type
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