Abstract：
:Domestic chickens (Gallus gallus) were used as a surrogate species for wild turkey to assess risk from environmental 2,3,7,8-TCDD exposure. Lymphocyte proliferation and CYP450 induction were assessed in adults exposed via i.m. injection, in F1 14-day old hatchlings, in F1 adults (30-weeks old), and in 14-day old hatchlings exposed via yolk sac injections. Hatchlings from injected eggs exhibited a dose-response in lymphocyte proliferation, IgM titers, EROD, and PROD endpoints. Exposed adults showed a significant dose-dependent increase in CYP450 induction. F1 14-day old chicks exhibited a significant dose-dependent suppression of B-cell proliferation and induction of CYP450 enzymes. F1 adult proliferative responses exhibited B-cell suppression, that was not statistically significant. Significant sex-dependent EROD and MROD induction was also observed in F1 adults, indicating mixed-function oxidase imprinting from maternal exposure.
journal_name
Chemospherejournal_title
Chemosphereauthors
Peden-Adams M,Alonso K,Godard C,Skipper S,Mashburn W,Hoover J,Charbonneau C,Henshel D,Dickerson Rdoi
10.1016/s0045-6535(98)00259-8subject
Has Abstractpub_date
1998-10-01 00:00:00pages
1923-39issue
9-12eissn
0045-6535issn
1879-1298pii
S0045-6535(98)00259-8journal_volume
37pub_type
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