Abstract：
:Pharmaceuticals being extensively and progressively used in human and veterinary medicine are emerging as significant environmental contaminants. Pharmaceuticals are designed to have a specific mode of action and many of them are persistent in the body. These features among others make pharmaceuticals to be evaluated for potential effects on aquatic flora and fauna. Low levels of pharmaceuticals have been detected in many countries in sewage treatment plant effluents, surface waters, groundwater and drinking waters. In contrast, there is a general scarcity of publicly available ecotoxicological data concerning pharmaceuticals. Interspecies toxicity correlations provide a tool for estimating contaminant sensitivity with known levels of uncertainty for a diversity of wildlife species. In this context, we have developed interspecies toxicity correlation between Daphnia magna (zooplankton) and fish (species according to OECD guidelines) assessing the ecotoxicological hazard potential of diverse 77 pharmaceuticals. The developed models are validated and consensus models are presented to predict toxicity of the individual compounds for any one species when the data for the other species are available. Informative illustrations of the contributing structural fragments which are responsible for the greater toxicity of the diverse pharmaceuticals are identified by the developed models. Developed models are also used to predict fish toxicities of 59 pharmaceuticals (for which Daphnia toxicities are present) and Daphnia toxicities of 30 pharmaceuticals (for which fish toxicities are present). This study will allow a better and comprehensive risk assessment of pharmaceuticals for which toxicity data is missing for a particular endpoint.
journal_name
Chemospherejournal_title
Chemosphereauthors
Kar S,Roy Kdoi
10.1016/j.chemosphere.2010.07.019subject
Has Abstractpub_date
2010-10-01 00:00:00pages
738-47issue
6eissn
0045-6535issn
1879-1298pii
S0045-6535(10)00800-3journal_volume
81pub_type
杂志文章相关文献
CHEMOSPHERE文献大全abstract：:Microcystins and copper commonly co-exist in the natural environment, but their combined toxicity remains unclear, especially in terrestrial plants. The present study investigated the toxicity effects of microcystin-LR (0, 5, 50, 500, 1000 μg L-1) and copper (0, 50, 500, 1000, 2000 μg L-1), both individually and in mi...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2018.05.051
更新日期：2018-09-01 00:00:00
abstract：:The ecological risks of antibiotics in aquatic environments have raised great concerns worldwide, but the chronic effect of antibiotic contaminants on cyanotoxin production and release remains unclear. This study investigated the long-term combined effects of spiramycin (SP) and ampicillin (AMP) on microcystin (MC) pr...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2019.06.192
更新日期：2019-11-01 00:00:00
abstract：:Sediments were collected from a stream (upstream, outfall and downstream) receiving copper laden catfish pond effluent to assess toxicity to non-target biota. No significant reduction in Hyalella azteca survival or growth (10 d), or Typha latifolia germination and root and shoot growth (7 d) were observed after exposu...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/s0045-6535(00)00354-4
更新日期：2001-07-01 00:00:00
abstract：AIM:We aimed to assess if snoring and ambient air pollutants were jointly associated with prevalent hypertension in a cross-sectional study. METHODS:A total of 28440 participants aged 18-79 years were obtained from the Henan Rural Cohort. Snoring evaluated using Pittsburgh sleep quality index (PSQI) scale was classifi...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2020.127108
更新日期：2020-10-01 00:00:00
abstract：:The goal of this study was to identify promising new biomarkers of phenanthrene by identifying differentially expressed proteins in Eisenia fetida after exposure to phenanthrene. Extracts of earthworm epithelium collected at days 2, 7, 14, and 28 after phenanthrene exposure were analyzed by two dimensional electrophor...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2013.05.062
更新日期：2013-10-01 00:00:00
abstract：:The bioremediation efficiency of petroleum hydrocarbons in natural soil-water systems is regulated by active microbial populations and other system parameters. Relevant factors include the transfer rate of petroleum contaminants from a medium into microorganisms, the partitioning behavior of contaminants from water in...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2019.05.202
更新日期：2019-10-01 00:00:00
abstract：:The efficiency of combining iron sulfate and organic amendments (paper mill sludge, olive mill waste compost and olive tree pruning biochar) for the remediation of an As- and Cu-contaminated soil was evaluated. Changes in As and Cu fractionation and solubility due to the application of the amendments was explored by l...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2016.09.039
更新日期：2016-12-01 00:00:00
abstract：:In late 1990s, USEPA/FDA made an important connection regarding the presence of elevated levels of dioxins (e.g., 1500 ng kg(-1) TEQ) in ball clays mined in Mississippi (USA) from a geological deposit dated to ~40 million years (Mississippi Embayment) that stretches over several states (northern part of Mississippi to...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2012.03.057
更新日期：2012-07-01 00:00:00
abstract：:In this work, the prepared mesoporous TiO2 was employed to eliminate the environmental risk induced by the combined pollution (tris-(2-chloroisopropyl) phosphate (TCPP) and Cd2+). The prepared material was characterized by X-ray diffraction (XRD), UV-vis diffuse reflectance spectra (UV-DRS), Raman imaging spectrometer...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2020.129238
更新日期：2021-03-01 00:00:00
abstract：:Taihu Basin is the most developed area in China, which economic development has resulted in pollutants being produced and discharged into rivers and the lake. Lake Taihu is located in the center of the basin, which is characterized by a complex network of rivers and channels. To assess the sources and fate of dissolve...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2010.10.049
更新日期：2011-01-01 00:00:00
abstract：:In this paper, a two dimensional/two dimensional (2D/2D) heterostructure of Ti3C2/g-C3N4 (T/CN) was constructed and used to activate peroxymonosulfate (PMS) for the degradation of diclofenac (DCF) in water in the presence of light illumination. Compared with single photocatalytic process by T/CN (0.040/min) and with p...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2020.127339
更新日期：2020-11-01 00:00:00
abstract：:Polychlorinated diphenyl ethers (PCDEs), 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) were analyzed in seals from the Gulf of Finland and in sediments from the Gulf of Finland and near Gotland. The sediments included one surface core from...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/s0045-6535(97)00212-9
更新日期：1997-09-01 00:00:00
abstract：:Bacterial regrowth in drinking water systems is a threat to public health. In this study, ferrihydrite (Fh) adsorption was compared with advanced drinking water treatment processes (ADWTP) during one and a half years of sampling to test the reduction in assimilable organic carbon (AOC) and bacterial regrowth potential...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2019.125001
更新日期：2020-02-01 00:00:00
abstract：:Although fluorotelomer alcohols (FTOHs) have been detected in various environmental matrices worldwide, no studies have been conducted to evaluate their concentrations in surface water or precipitation. Therefore, we developed a sensitive and reliable method to analyze various environmental aqueous samples for the pre...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2008.08.029
更新日期：2009-01-01 00:00:00
abstract：:Pharmaceuticals as environmental contaminants have received a lot of interest over the past decade but, for several pharmaceuticals, relatively little is known about their occurrence in European surface waters. Benzodiazepines, a class of pharmaceuticals with anxiolytic properties, have received interest due to their ...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2017.02.126
更新日期：2017-06-01 00:00:00
abstract：:Effective removal of cadmium (Cd) from Chlamys farreri by introducing ZnSO4, EDTA-Na2, and sodium citrate into seawater has previously been reported. However, some mechanisms underlying this removal are not clear. To address this lack of clarity, the present study aimed to investigate the changes of Cd forms in Chlamy...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2020.127802
更新日期：2021-01-01 00:00:00
abstract：:Preparation conditions of Fe-Cu-Ag trimetallic particles were optimized by single-factor and response surface methodology (RSM) batch experiments to obtain high-reactive Fe0-based materials for p-nitrophenol (PNP) removal. Under the optimal conditions (i.e., Fe0 dosage of 34.86 g L-1, theoretical Cu mass loading of 81...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2017.07.038
更新日期：2017-11-01 00:00:00
abstract：:Head lettuce plantlets (Lactuca sativa L. var. capitata) were potted, treated with vinclozolin at the six-leaf stage according to application standards and allowed to dry for 24 h. The potted plantlets were then placed in either growth chambers with controlled temperature (20 and 25 degrees C, respectively) or in a gr...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/s0045-6535(02)00049-8
更新日期：2002-07-01 00:00:00
abstract：:A method for the determination of polybrominated diphenyl ethers (PBDEs) in biota for routine analysis is described. The mass spectroscopic (MS) evaluation of 23 brominated diphenyl ethers, under electron ionization and electron capture negative ion conditions using magnetic sector and quadrupole mass spectrometers, s...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/s0045-6535(00)00311-8
更新日期：2001-09-01 00:00:00
abstract：:Polycyclic aromatic hydrocarbon (PAH) dissipation efficiency can be increased in the plant rhizosphere, but may be affected by various environmental factors. We investigated the effects of the watering regime and phosphorus concentration on PAH dissipation in the rhizosphere of mycorrhizal plants in a pot experiment. ...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2009.08.050
更新日期：2009-10-01 00:00:00
abstract：:Hydrothermal carbonization (HTC) has become an esteemed method to convert sewage sludge into biochar. Besides dewatering and disinfection the process is suggested to reduce the micropollutant load, which would be beneficial for the use of biochar as fertilizer. This study was designed to examine reduction of micropoll...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2016.03.051
更新日期：2016-06-01 00:00:00
abstract：:A biotic ligand model (BLM) was developed to predict nickel toxicity, affecting root growth of barley (Hordeum vulgare), in nutrient solutions. The extent to which Ca(2+), Mg(2+), Na(+), K(+) ions and pH each influenced nickel toxicity was determined. Higher activities of Mg(2+) linearly increased the 4d EC50 Ni (2+) ...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2006.07.008
更新日期：2007-01-01 00:00:00
abstract：:We determined the kinetics of phenanthrene desorption from three activated carbons to water using Tenax beads as an infinite sink for organic compounds in water. Desorption kinetic data very well fitted a biphasic kinetic model based on the presence of two different adsorption sites, viz. low-energy sites and high-ene...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2008.01.048
更新日期：2008-05-01 00:00:00
abstract：:The potential toxicity of copper nanoparticles (CuNPs) to early stages of fishes is not fully understood, and little is known about their effects on ionocytes and associated functions. This study used zebrafish embryos as a model to investigate the toxic effects of CuNPs on two subtypes of ionocytes. Zebrafish embryos...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2020.128051
更新日期：2020-12-01 00:00:00
abstract：:Copper is an essential micronutrient for plants. Present at a high concentration in soil, copper is also regarded as a major toxicant to plant cells due to its potential inhibitory effects against many physiological and biochemical processes. The interference of germination-related proteins by heavy metals has not bee...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2006.10.075
更新日期：2007-04-01 00:00:00
abstract：:In the present investigation, eleven human adipose tissue samples, two seal blubber samples and two pelican muscles samples were analyzed with regard to their concentrations of PCB parent compounds as well as to the respective chiral methylsulfonyl metabolites 3-MeSO2-CB 91, 4-MeSO2-CB 91, 3-MeSO2-CB 95, 4-MeSO2-CB 95...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2006.05.081
更新日期：2007-04-01 00:00:00
abstract：:Polybrominated diphenyl ethers (PBDEs) are flame retardants generally employed in manufacturing household items. Surface water may remove and carry these chemicals to the drainage upon disposal of the items, and ultimately the chemicals enter our food chain. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) is a PBDE congen...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2017.04.089
更新日期：2017-08-01 00:00:00
abstract：:Nitric oxide (NO) is an intermediate of denitrification process and can be produced by denitrifiers, nitrifiers and other bacteria. In our experiments we measured the dynamic flow of NO depending on oxidation reduction potential (ORP). Different ORP-ranges were related to various carbon loading stages in the wastewate...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/s0045-6535(00)00342-8
更新日期：2001-08-01 00:00:00
abstract：:The coastal ecosystem in the northern Gulf of Mexico (GoM) has been seriously impacted by the 2010 BP oil spill. Two experiments were conducted to study the effect of temperature and addition of the dispersant on biodegradation of benzene, as a representative of petroleum hydrocarbon, in a coastal salt marsh sediment ...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2018.04.025
更新日期：2018-08-01 00:00:00
abstract：:Food contamination with cadmium (Cd) is a serious health threat to humans worldwide and Cd accumulation by rice is a major source of Cd entrance to the food chain. Silicon (Si) application decreases the Cd content in rice but the timing of Si application may need further investigation. The present study investigated t...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2019.03.182
更新日期：2019-07-01 00:00:00
