The EBV-encoded LMP1 protein inhibits p53-triggered apoptosis but not growth arrest.

abstract：:ERM is a member of the ETS transcription factor family. High levels of the corresponding mRNA are detected in a variety of human breast cancer cell lines, as well as in aggressive human breast tumors. As ERM protein is almost undetectable in these cells, high degradation of this transcription factor has been postulate...

journal_title：Oncogene

authors： Baert JL,Beaudoin C,Monte D,Degerny C,Mauen S,de Launoit Y

更新日期：2007-01-18 00:00:00

abstract：:The angiogenic peptide adrenomedullin (ADM) has been implicated as a mediator of the increased risk of endometrial hyperplasia and cancer resulting from the use of tamoxifen for the treatment and prevention of breast cancer. ADM has been shown to be induced by tamoxifen in the endometrium and to be a growth factor for...

journal_title：Oncogene

authors： Oehler MK,Hague S,Rees MC,Bicknell R

更新日期：2002-04-25 00:00:00

abstract：:Density-enhanced protein-tyrosine phosphatase-1 (DEP-1 also CD148) is a transmembrane molecule with a single intracellular PTP domain. It has recently been proposed to function as a tumor suppressor. We have previously shown that DEP-1 dephosphorylates the activated platelet-derived growth factor (PDGF) beta-receptor ...

journal_title：Oncogene

authors： Jandt E,Denner K,Kovalenko M,Ostman A,Böhmer FD

更新日期：2003-07-03 00:00:00

abstract：:Urothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs). By quantitative real-time polymerase chain reaction array, we found that one potential TSG, angiopoietin-like 4 (ANGPTL4), was expressed at very low levels in all bladder cancer cell ...

journal_title：Oncogene

authors： Hsieh HY,Jou YC,Tung CL,Tsai YS,Wang YH,Chi CL,Lin RI,Hung SK,Chuang YM,Wu SF,Li C,Shen CH,Chan MWY,Hsu CD

更新日期：2018-02-01 00:00:00

abstract：:Knowledge of tumour initiation in human epithelia is limited by sample availability and difficulty in experimental manipulation of human cells. The thyroid is a useful model since, in addition to multiple tumour stages, it presents two distinct 'pathways' of tumorigenesis: 'follicular' tumours, in which ras oncogene m...

journal_title：Oncogene

authors： Bond JA,Wyllie FS,Rowson J,Radulescu A,Wynford-Thomas D

更新日期：1994-01-01 00:00:00

abstract：:As apoptosis defects limit efficacy of anticancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the mechanism by which radiat...

journal_title：Oncogene

authors： Kim KW,Moretti L,Mitchell LR,Jung DK,Lu B

更新日期：2010-06-03 00:00:00

abstract：:We have previously shown (Smith et al., 1994) that antibodies raised against the growth arrest and DNA damage inducible protein Gadd45 co-precipitate proliferating cell nuclear antigen (PCNA), a protein involved in DNA replication and repair. Here we demonstrate that Gadd45 can directly bind to PCNA using a Far-wester...

journal_title：Oncogene

authors： Chen IT,Smith ML,O'Connor PM,Fornace AJ Jr

更新日期：1995-11-16 00:00:00

abstract：:Oncolytic adenoviruses, such as Delta-24-RGD (Δ24RGD), are replication-competent viruses that are genetically engineered to induce selective cancer cell lysis. In cancer cells, Δ24RGD induces massive autophagy, which is required for efficient cell lysis and adenoviral spread. Understanding the cellular mechanisms unde...

journal_title：Oncogene

authors： Klein SR,Piya S,Lu Z,Xia Y,Alonso MM,White EJ,Wei J,Gomez-Manzano C,Jiang H,Fueyo J

更新日期：2015-10-08 00:00:00

abstract：:Promoter hypermethylation is an important means for the transcriptional repression of a number of cancer-associated genes. However, the underlying mechanism of this aberration in cancer remains unclear. Here, we examined 5' CpG island methylation status and expression of the p14(ARF), p16(INK4a) and RASSF1A tumor supp...

journal_title：Oncogene

authors： Sato M,Horio Y,Sekido Y,Minna JD,Shimokata K,Hasegawa Y

更新日期：2002-07-18 00:00:00

abstract：:Transforming growth factor-beta 1 (TGF-beta 1) inhibits most epithelial cell types by blocking cell cycle progression during the G1 phase. D cyclins are normally expressed during G1 and are regulators of G1 progression. One of the crucial functions of D cyclins is their ability to bind to a cyclin-dependent kinase (Cd...

journal_title：Oncogene

authors： Ko TC,Sheng HM,Reisman D,Thompson EA,Beauchamp RD

更新日期：1995-01-05 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine with important roles in regulating inflammatory responses as well as cell cycle proliferation and apoptosis. Although TNFalpha stimulates apoptosis, it also activates the transcription factor NF-kappa B, and studies have shown that inhibition of NF-...

journal_title：Oncogene

authors： Zhou A,Scoggin S,Gaynor RB,Williams NS

更新日期：2003-04-03 00:00:00

abstract：:Mutations of SMAD4/DPC4 are found in about 60% of human invasive pancreatic ductal adenocarcinomas (PDACs); yet, the manner in which SMAD4 deficiency enhances tumorigenesis remains elusive. Using a Cre-LoxP approach, we generated a mutant mouse carrying a targeted deletion of Smad4 in the pancreas. We showed that the ...

journal_title：Oncogene

authors： Xu X,Ehdaie B,Ohara N,Yoshino T,Deng CX

更新日期：2010-02-04 00:00:00

abstract：:Previously, we have mimicked human neurofibromatosis type 2 (NF2) in conditional Nf2 mutant (P0Cre;Nf2flox2/flox2) mice. Schwannomas, characteristic for NF2, were found at low frequency in older mice. Here, we report that these mice, upon additional hemizygosity for p53, rapidly develop multiple tumours showing featur...

journal_title：Oncogene

authors： Robanus-Maandag E,Giovannini M,van der Valk M,Niwa-Kawakita M,Abramowski V,Antonescu C,Thomas G,Berns A

更新日期：2004-08-26 00:00:00

abstract：:We have recently described the N-terminal RAS association domain family of genes, RASSF7-10. Previously, we cloned the N-terminal RASSF10 gene and demonstrated frequent methylation of the associated 5'-CpG island in acute lymphoblastic leukemia. To characterize RASSF10 gene expression, we demonstrate that in developin...

journal_title：Oncogene

authors： Hill VK,Underhill-Day N,Krex D,Robel K,Sangan CB,Summersgill HR,Morris M,Gentle D,Chalmers AD,Maher ER,Latif F

更新日期：2011-02-24 00:00:00

abstract：:Wilms tumours (WTs) have two distinct types of histology with or without ectopic mesenchymal elements, suggesting that WTs arise from either the mesenchymal or epithelial nephrogenic lineages. Regardless of the presence or absence of CTNNB1 mutations, nuclear accumulation of beta-catenin is often observed in WTs with ...

journal_title：Oncogene

authors： Fukuzawa R,Anaka MR,Weeks RJ,Morison IM,Reeve AE

更新日期：2009-02-26 00:00:00

abstract：:The cochaperone CDC37 promotes the association of HSP90 with the protein kinase subset of client proteins to maintain their stability and signalling functions. HSP90 inhibitors induce depletion of clients, which include several oncogenic kinases. We hypothesized that the targeting of CDC37 using siRNAs would compromis...

journal_title：Oncogene

authors： Smith JR,Clarke PA,de Billy E,Workman P

更新日期：2009-01-15 00:00:00

abstract：:Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis Complex 1 (TSC1) and TSC2 play a fundamental role in cell homeostasis, where signal transduction through TSC1/TSC2 is often compromised in cancer, leading to aberra...

journal_title：Oncogene

authors： Johnson CE,Dunlop EA,Seifan S,McCann HD,Hay T,Parfitt GJ,Jones AT,Giles PJ,Shen MH,Sampson JR,Errington RJ,Davies DM,Tee AR

更新日期：2018-11-01 00:00:00

abstract：:There is strong evidence at the individual level and the population level that an efficient cytotoxic T lymphocyte (CTL) response to HTLV-1 limits the proviral load and the risk of associated inflammatory diseases such as HAM/TSP. This evidence comes from host population genetics, viral genetics, DNA expression microa...

journal_title：Oncogene

authors： Bangham CR,Osame M

更新日期：2005-09-05 00:00:00

abstract：:Exposure of normal adult human skin to doses of UV irradiation that induced mild sunburn resulted in the rapid appearance of p53 protein in the epidermis and superficial dermal fibroblasts. Immunohistological analysis with a panel of antibodies established that while p53 staining was not seen in normal skin it appeare...

journal_title：Oncogene

authors： Hall PA,McKee PH,Menage HD,Dover R,Lane DP

更新日期：1993-01-01 00:00:00

abstract：:The heterodimeric nuclear factor (NF) 90/NF45 complex (NF90/NF45) binds nucleic acids and is a multifunctional regulator of gene expression. Here we report that depletion of NF90/NF45 restores the expression of the p53 and p21 proteins in cervical carcinoma cells infected with high-risk human papillomaviruses (HPVs). ...

journal_title：Oncogene

authors： Shamanna RA,Hoque M,Pe'ery T,Mathews MB

更新日期：2013-10-24 00:00:00

abstract：:Transgenic mice expressing the c-Myc oncogene driven by woodchuck hepatitis virus (WHV) regulatory sequences develop hepatocellular carcinoma with a high frequency. To investigate genetic lesions that cooperate with Myc in liver carcinogenesis, we conducted a genome-wide scan for loss of heterozygosity (LOH) and mutat...

journal_title：Oncogene

authors： Wu Y,Renard CA,Apiou F,Huerre M,Tiollais P,Dutrillaux B,Buendia MA

更新日期：2002-02-28 00:00:00

abstract：:The breast cancer-associated protein, BARD1, colocalizes with BRCA1 in nuclear foci in the S phase and after DNA damage, and the two proteins form a stable heterodimer implicated in DNA repair, protein ubiquitination, and control of mRNA processing. BARD1 has a BRCA1-independent proapoptotic activity; however, little ...

journal_title：Oncogene

authors： Rodriguez JA,Schüchner S,Au WW,Fabbro M,Henderson BR

更新日期：2004-03-11 00:00:00

abstract：:The p53 gene is frequently mutated in cancers and it is vital for cell cycle control, homeostasis and carcinogenesis. We describe a novel p53 mutational spectrum, different to those generally observed in human and murine tumors. Our study shows a high prevalence of nonsense mutations in the p53 N terminus of 2-acetyla...

journal_title：Oncogene

authors： Melis JP,Hoogervorst EM,van Oostrom CT,Zwart E,Breit TM,Pennings JL,de Vries A,van Steeg H

更新日期：2011-04-14 00:00:00

abstract：:Several small GTPases of the Ras superfamily have been shown to antagonize TGFbeta signaling in human tumor cell lines. Some of these GTPases are post-translationally modified by farnesylation, a lipid modification catalyzed by farnesyltransferase and required for the proteins to attach to membranes and to function. I...

journal_title：Oncogene

authors： Adnane J,Bizouarn FA,Chen Z,Ohkanda J,Hamilton AD,Munoz-Antonia T,Sebti SM

更新日期：2000-11-16 00:00:00

abstract：:The tumor microenvironment plays a critical role in prostate cancer (PC) development and progression. Inappropriate activation of the stroma potentiates the growth and transformation of epithelial tumor cells. Here, we show that upregulation of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine...

journal_title：Oncogene

authors： Li J,Pu T,Yin L,Li Q,Liao CP,Wu BJ

更新日期：2020-04-01 00:00:00

abstract：:Although TGFalpha mRNA and protein are frequently elevated in neoplastic cells, neither the level at which deregulation occurs nor the mechanism(s) responsible have been well characterized. As a first step, we examined the induction of TGFalpha mRNA in two series of clonally-derived rat liver epithelial cell lines tha...

journal_title：Oncogene

authors： Berkowitz EA,Hissong MA,Lee DC

更新日期：1996-05-02 00:00:00

abstract：:A33 antigen is a membrane-bound protein that is expressed only in intestinal epithelium and in most human colon cancers. Thus, A33 antigen has been explored as a potential therapeutic target for the treatment of colon cancers. However, little is known about the mechanism responsible for the tissue-specific pattern of ...

journal_title：Oncogene

authors： Mao Z,Song S,Zhu Y,Yi X,Zhang H,Shang Y,Tong T

更新日期：2003-07-10 00:00:00

abstract：:Germline mutations in the p53 tumor suppressor gene are associated with the Li-Fraumeni syndrome, characterized by childhood sarcoma, leukemia and early onset breast cancer and has occasionally been found also in familial breast-ovarian cancer. Most mutations found are of missense type and located in the central regio...

journal_title：Oncogene

authors： Sun XF,Johannsson O,Håkansson S,Sellberg G,Nordenskjöld B,Olsson H,Borg A

更新日期：1996-07-18 00:00:00

abstract：:Ovarian cancer (OvCa) exhibits a specific predilection for metastasis to the omentum. Our earlier studies highlighted the tumour-suppressor effect of secreted protein acidic and rich in cysteine (SPARC) in OvCa through multi-faceted roles inhibiting cancer cell interactions within the peritoneal milieu. The goal of th...

journal_title：Oncogene

authors： John B,Naczki C,Patel C,Ghoneum A,Qasem S,Salih Z,Said N

更新日期：2019-05-01 00:00:00

abstract：:The antifolates were the first class of antimetabolites to enter the clinics more than 50 years ago. Over the following decades, a full understanding of their mechanisms of action and chemotherapeutic potential evolved along with the mechanisms by which cells develop resistance to these drugs. These principals served ...

journal_title：Oncogene

authors： Zhao R,Goldman ID

更新日期：2003-10-20 00:00:00