Abstract：
:Acrylamide (AA) is a carcinogen as demonstrated in animal experiments, but the relevance for the human situation is still unclear. AA and its metabolite glycidamide (GA) react with nucleophilic regions in biomolecules. However, whereas AA and GA react with proteins, DNA adducts are exclusively formed by GA under conditions simulating in vivo situations. For risk assessment it is of particular interest to elucidate whether AA or GA within the plasma concentration range resulting from food intake are "quenched" by preferential reaction with non-critical blood constituents or whether DNA in lymphocytes is damaged concomitantly under such conditions. To address this question dose- and time-dependent induction of hemoglobin (Hb) adducts as well as genotoxic and mutagenic effects by AA or GA were studied in human blood as a model system.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Baum M,Fauth E,Fritzen S,Herrmann A,Mertes P,Rudolphi M,Spormann T,Zankl H,Eisenbrand G,Bertow Ddoi
10.1007/0-387-24980-X_6subject
Has Abstractpub_date
2005-01-01 00:00:00pages
77-88eissn
0065-2598issn
2214-8019journal_volume
561pub_type
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