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Influence of pancreas and kidney transplant function on recipient survival.

Abstract：

:The aim of this study was to evaluate long-term survival after simultaneous pancreas and kidney (SPK) transplantation in relation to function of both grafts. Among 67 recipients who received SPK transplants between 1988 and 2004, 35 had follow-up longer than 18 months, and were divided into: group I (n = 20), recipients with good function of both grafts; group II (n = 7), patients who had lost transplanted pancreas but had still good kidney graft function; group III (n = 8), patients who had lost both grafts. Comparison of survival rates and analysis of the reason of mortality among groups was performed. The cumulative survival rate was significantly higher in group I than in group III (after 3, 5, 10 years: 100%, 100%, 80% vs 75%, 50%, 37%, respectively). Cumulative survival rate for group II after 3, 5, 10 years was 100%, 100%, 33%, respectively. There were no significant differences in survival rates between groups I and II and between groups II and III. In group I deaths for cardiovascular event and for leukemia were noted. In group II deaths due to cardiovascular event and sepsis were observed. In group III all patients died due to cardiovascular events and the mean time from loss of pancreas and kidney graft function to death was: 75 +/- 51 months (range from 19 to 142), and 49 +/- 26 months (range 19 to 99), respectively. Good pancreas and kidney graft functions prevent death due to cardiovascular event.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Szmidt J,Grochowiecki T,Gałazka Z,Nazarewski S,Madej K,Frunze S,Chudziński W,Durlik M,Paczek L,Jakimowicz T,Rongies W,Kański A

doi

10.1016/j.transproceed.2005.12.038

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

263-5

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)01495-8

journal_volume

38

pub_type

杂志文章

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