Pilot study of radiotherapy with misonidazole in head and neck cancer.

Abstract:

:Twenty-nine patients with advanced carcinoma of the upper air and food passages were treated by radiotherapy using a 10-fraction three-week scheme, giving 1.2 g/m2 of misonidazole 4 h before each treatment. Complete tumour regression was observed in 24 of the patients, and at a nine-month follow-up the local tumour control rate is 60%. Sixteen patients developed evidence of peripheral neuropathy. A prospective random controlled trial is recommended to confirm the apparently improved local tumour control from the use of misonidazole in this study.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Paterson IC,Dawes PJ,Henk JM,Moore JL

doi

10.1016/s0009-9260(81)80166-3

subject

Has Abstract

pub_date

1981-03-01 00:00:00

pages

225-9

issue

2

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(81)80166-3

journal_volume

32

pub_type

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