Tc-99m hydroxymethylene diphosphonate SPECT/CT for the evaluation of osteonecrosis of the jaw: preliminary study on diagnostic ability of maximum standardised uptake value.

Abstract:

AIM:To investigate the diagnostic ability of maximum standardised uptake value (SUVmax) at combined single-photon-emission computed tomography/computed tomography (SPECT/CT) for the evaluation of osteonecrosis of the jaw. MATERIALS AND METHODS:Seven patients with mandibular osteonecrosis (three osteoradionecrosis, three medication-related osteonecrosis of the jaw (MRONJ), and one rheumatoid arthritis) underwent SPECT/CT at 4 hours after injection of technetium 99m hydroxymethylene diphosphonate. The SPECT/CT parameters SUVmax were compared for the osteonecrosis with normal mandible. Statistical analyses among the SUVmax of osteonecrosis were performed by one-way repeated measures analysis of variance with Tukey's HSD (honestly significant difference) test. A p-value <0.05 was considered statistically significant. RESULTS:SUVmax for MRONJ and rheumatoid arthritis (23.24±8.63) were significantly higher than those for osteoradionecrosis (9.05±1.39, p=0.005) and normal mandible (3.57±0.46, p=0.000). CONCLUSIONS:SUVmax derived from bone SPECT/CT could be useful for the evaluation of osteonecrosis of the jaw.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Ogura I,Sasaki Y,Sue M,Oda T,Kameta A,Hayama K

doi

10.1016/j.crad.2019.05.025

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

46-50

issue

1

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(19)30266-1

journal_volume

75

pub_type

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