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Enhancement of vincristine- and adriamycin-induced cytotoxicity by verapamil in P388 leukemia and its sublines resistant to vincristine and adriamycin.

Abstract：

:A calcium antagonist, verapamil, enhanced the cellular uptake and cytotoxicity of vincristine (VCR) in adriamycin-resistant P388 leukemia (P388/ADM) cells and also enhanced the cellular uptake and cytotoxicity of adriamycin (ADM) in vincristine-resistant P388 leukemia (P388/VCR) and P388/ADM cells. The enhancement of cytotoxicity and cellular uptake of VCR in P388 and P388/VCR cells has been reported previously. [1]. VCR and ADM resistance was circumvented by verapamil. A common transport mechanism for VCR and ADM, which is responsive to verapamil, seems to exist in VCR- and ADM-resistant cells. However, the enhancement of ADM cytotoxicity and cellular uptake by verapamil was not evident in P388 cells.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Tsuruo T,Iida H,Yamashiro M,Tsukagoshi S,Sakurai Y

doi

10.1016/0006-2952(82)90097-1

subject

Has Abstract

pub_date

1982-10-01 00:00:00

pages

3138-40

issue

19

eissn

0006-2952

issn

1873-2968

pii

0006-2952(82)90097-1

journal_volume

31

pub_type

杂志文章

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