Hemodynamic effects of massive doses of dexamethasone in controlled hypovolemic shock in the dog.

Abstract:

:The hemodynamic effects of massive doses of dexamethasone in combination with the alpha-adrenergic blocking agent phenoxybenzamine were studied in dogs subjected to hemorrhagic hypotension. Previously it has been shown that the glucocorticoid methylprednisolone, but not the glucocorticoid betamethasone, induces a pronounced vasodilation in combination with phenoxybenzamine. In the present study it was found that also dexamethasone (a stereoisomer of betamethasone) is unable to increase the peripheral blood flow after phenoxybenzamine. Since equivalent doses were used in relation to glucocorticoid activity, it seems reasonable to conclude that the different hemodynamic patterns are unrelated to the glucocorticoid ability of the drugs. Furthermore, it is unlikely that possible beneficial effects of dexamethasone in hypovolemic shock are due to a direct vascular influence.

authors

Hellman A,Häggendal E,Lundberg D

doi

10.1111/j.1399-6576.1982.tb01758.x

subject

Has Abstract

pub_date

1982-06-01 00:00:00

pages

222-4

issue

3

eissn

0001-5172

issn

1399-6576

journal_volume

26

pub_type

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