Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina.

Abstract:

:Stimulus threshold and response latencies were measured for electrically elicited retinal ganglion cell responses in retina isolated from the eyes of normal and retinal degenerate (rd1) mice. Stimulation of the ganglion cell-side in normal retina yielded a significantly lower mean threshold and shorter latency when compared with stimulation of the photoreceptor side in normal retina. The latency of the ganglion cell-side stimulation in normal retina also proved to be significantly shorter than the latency for stimulation of the ganglion cell side in rd1 retina. Thus both the electrode positioning as well as the health of the retinal tissue play a role in the stimulating current required to elicit a retinal response.

journal_name

Vision Res

journal_title

Vision research

authors

O'Hearn TM,Sadda SR,Weiland JD,Maia M,Margalit E,Humayun MS

doi

10.1016/j.visres.2006.03.031

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

3198-204

issue

19

eissn

0042-6989

issn

1878-5646

pii

S0042-6989(06)00190-8

journal_volume

46

pub_type

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