Abstract:
:In this work, optical retardation (OR) was investigated in corneal stroma collagen fibers from nonobese diabetic (NOD) and healthy (BALB/c) mice. Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR values than the control. Ponceau SS-complexed collagen fibers showed positive LD that was higher for NOD corneas. After staining with Toluidine Blue, NOD and BALB/c corneas showed negative LD. The results of this study demonstrate that diabetes was capable of altering the corneal optical anisotropies, possibly altering the number of intermolecular crosslinks in collagen fibers.
journal_name
Vision Resjournal_title
Vision researchauthors
Aldrovani M,Guaraldo AM,Vidal BCdoi
10.1016/j.visres.2007.02.011subject
Has Abstractpub_date
2007-12-01 00:00:00pages
3229-37issue
26eissn
0042-6989issn
1878-5646pii
S0042-6989(07)00089-2journal_volume
47pub_type
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