Altered white matter in early visual pathways of humans with amblyopia.

Abstract:

:Amblyopia is a visual disorder caused by poorly coordinated binocular input during development. Little is known about the impact of amblyopia on the white matter within the visual system. We studied the properties of six major visual white-matter pathways in a group of adults with amblyopia (n=10) and matched controls (n=10) using diffusion weighted imaging (DWI) and fiber tractography. While we did not find significant differences in diffusion properties in cortico-cortical pathways, patients with amblyopia exhibited increased mean diffusivity in thalamo-cortical visual pathways. These findings suggest that amblyopia may systematically alter the white matter properties of early visual pathways.

journal_name

Vision Res

journal_title

Vision research

authors

Allen B,Spiegel DP,Thompson B,Pestilli F,Rokers B

doi

10.1016/j.visres.2014.12.021

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

48-55

eissn

0042-6989

issn

1878-5646

pii

S0042-6989(15)00005-X

journal_volume

114

pub_type

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