Abstract：
:The Wernicke-Lichtheim-Geschwind (WLG) theory of the neurobiological basis of language is of great historical importance, and it continues to exert a substantial influence on most contemporary theories of language in spite of its widely recognized limitations. Here, we suggest that neurobiologically grounded computational models based on the WLG theory can provide a deeper understanding of which of its features are plausible and where the theory fails. As a first step in this direction, we created a model of the interconnected left and right neocortical areas that are most relevant to the WLG theory, and used it to study visual-confrontation naming, auditory repetition, and auditory comprehension performance. No specific functionality is assigned a priori to model cortical regions, other than that implicitly present due to their locations in the cortical network and a higher learning rate in left hemisphere regions. Following learning, the model successfully simulates confrontation naming and word repetition, and acquires a unique internal representation in parietal regions for each named object. Simulated lesions to the language-dominant cortical regions produce patterns of single word processing impairment reminiscent of those postulated historically in the classic aphasia syndromes. These results indicate that WLG theory, instantiated as a simple interconnected network of model neocortical regions familiar to any neuropsychologist/neurologist, captures several fundamental "low-level" aspects of neurobiological word processing and their impairment in aphasia.
journal_name
Brain Langjournal_title
Brain and languageauthors
Weems SA,Reggia JAdoi
10.1016/j.bandl.2006.06.001subject
Has Abstractpub_date
2006-09-01 00:00:00pages
291-309issue
3eissn
0093-934Xissn
1090-2155pii
S0093-934X(06)00112-Xjournal_volume
98pub_type
杂志文章,评审abstract：:We conducted an Activation Likelihood Estimation (ALE) meta-analysis to identify brain regions that are recruited by linguistic stimuli requiring relatively demanding semantic or syntactic processing. We included 54 functional MRI studies that explicitly varied the semantic or syntactic processing load, while holding ...
journal_title：Brain and language
pub_type： 杂志文章,meta分析
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abstract：:Memory for action phrases improves in the listeners when the speaker accompanies them with gestures compared to when the speaker stays still. Since behavioral studies revealed a pivotal role of the listeners' motor system, we aimed to disentangle the role of primary motor and premotor cortices. Participants had to rec...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2018.03.001
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abstract：:Closed head injury (CHI) is associated with communication difficulties in everyday social interactions. Previous work has reported impaired comprehension of sarcasm, using sarcastic remarks where the intended meaning is the opposite of the sincere or literal meaning. Participants with CHI in the present study were ass...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2004.09.002
更新日期：2005-05-01 00:00:00
abstract：:Say and Clahsen (S and C) report an experiment involving assignment of past participle suffixes to nonce words in Italian. Their evidence suggests a dual-route model that assigns the theme vowel of the 1st conjugation, while storing it lexically in other conjugations. However, these nonce words were assigned suffixes ...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.2001.2525
更新日期：2002-04-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2018.01.007
更新日期：2018-12-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2017.11.001
更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0093-934x(92)90093-t
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2006.12.004
更新日期：2007-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bandl.2007.04.005
更新日期：2008-02-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(84)90087-7
更新日期：1984-05-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2007.08.007
更新日期：2007-12-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.1993.1024
更新日期：1993-05-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2008.03.004
更新日期：2008-08-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/S0093-934X(03)00435-8
更新日期：2004-07-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2010.06.004
更新日期：2012-02-01 00:00:00
abstract：:Lexical processing has long been associated with left-hemisphere function, especially for infrequently occurring words. Recently, however, persons with severe aphasia, including word-recognition deficits, were observed to recognize familiar proper nouns. Further, some patients suffering right-hemisphere damage were po...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.2000.2365
更新日期：2001-05-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.2000.2405
更新日期：2001-06-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.1999.2185
更新日期：1999-12-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章,评审
doi：10.1006/brln.1994.1008
更新日期：1994-01-01 00:00:00
abstract：:Formal lexical errors are relatively rare in the production of aphasic patients. In this study, we report the case of DW, who makes a high proportion of these errors. A few other cases have previously been reported, but DW shows a number of distinguishing characteristics. First, formal lexical errors are made in spell...
journal_title：Brain and language
pub_type： 杂志文章
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journal_title：Brain and language
pub_type： 杂志文章,评审
doi：10.1016/j.bandl.2013.01.001
更新日期：2013-12-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2005.05.002
更新日期：2006-09-01 00:00:00
abstract：:Stuttering is associated with atypical structural and functional connectivity in sensorimotor brain areas, in particular premotor, motor, and auditory regions. It remains unknown, however, which specific mechanisms of speech planning and execution are affected by these neurological abnormalities. To investigate pre-mo...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2015.03.002
更新日期：2015-04-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.1996.0019
更新日期：1996-02-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(87)90102-7
更新日期：1987-03-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(90)90148-a
更新日期：1990-10-01 00:00:00
abstract：:A variety of experimental paradigms has yielded surprisingly fine-grained evidence about the kinds of syntactic information to which agrammatic aphasics are sensitive. This paper contrasts three accounts of agrammatism which draw quite different conclusions about the implications of this disorder for normal function: ...
journal_title：Brain and language
pub_type： 杂志文章,评审
doi：10.1006/brln.1995.1040
更新日期：1995-07-01 00:00:00
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journal_title：Brain and language
pub_type： 评论,杂志文章
doi：10.1006/brln.2000.2432
更新日期：2001-02-01 00:00:00
abstract：:Verbal humor deficits were investigated in right-hemisphere-damaged patients. It was hypothesized that the appreciation of jokes presupposes two elements: sensitivity to the surprise element entailed in the punch line of a joke and apprehension of the coherence which results when the punch line has been integrated wit...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(83)90002-0
更新日期：1983-01-01 00:00:00
