Abstract：
:Auditory speech comprehension is the result of neural computations that occur in a broad network that includes the temporal lobe auditory cortex and the left inferior frontal cortex. It remains unclear how representations in this network differentially contribute to speech comprehension. Here, we recorded high-density direct cortical activity during a sine-wave speech (SWS) listening task to examine detailed neural speech representations when the exact same acoustic input is comprehended versus not comprehended. Listeners heard SWS sentences (pre-exposure), followed by clear versions of the same sentences, which revealed the content of the sounds (exposure), and then the same SWS sentences again (post-exposure). Across all three task phases, high-gamma neural activity in the superior temporal gyrus was similar, distinguishing different words based on bottom-up acoustic features. In contrast, frontal regions showed a more pronounced and sudden increase in activity only when the input was comprehended, which corresponded with stronger representational separability among spatiotemporal activity patterns evoked by different words. We observed this effect only in participants who were not able to comprehend the stimuli during the pre-exposure phase, indicating a relationship between frontal high-gamma activity and speech understanding. Together, these results demonstrate that both frontal and temporal cortical networks are involved in spoken language understanding, and that under certain listening conditions, frontal regions are involved in discriminating speech sounds.
journal_name
Brain Langjournal_title
Brain and languageauthors
Khoshkhoo S,Leonard MK,Mesgarani N,Chang EFdoi
10.1016/j.bandl.2018.01.007subject
Has Abstractpub_date
2018-12-01 00:00:00pages
83-91eissn
0093-934Xissn
1090-2155pii
S0093-934X(17)30071-8journal_volume
187pub_type
杂志文章abstract：:The traditional clinical picture for English nonfluent aphasics has generally presented the deficit as one of total loss of control over grammatical morphology, with some sparing of word order. This is at odds with recent research involving nonfluent aphasic speakers of highly inflected languages, which has shown that...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(91)90156-u
更新日期：1991-08-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2018.02.001
更新日期：2018-04-01 00:00:00
abstract：:This case report documents the partial recovery, over a 12-month period, of pure alexia in an adult female following a left occipital infarction. Measures of speed and accuracy were obtained on an oral reading and a lexical decision task immediately postonset and then on 10 subsequent occasions. Explicit letter-by-let...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(90)90148-a
更新日期：1990-10-01 00:00:00
abstract：:Since Aristotle, people have believed that metaphors and similes express the same type of figurative meaning, despite the fact that they are expressed with different sentence patterns. In contrast, recent psycholinguistic models have suggested that metaphors and similes may promote different comprehension processes. I...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2012.03.006
更新日期：2012-06-01 00:00:00
abstract：:In an implicit phonological priming paradigm, deaf bimodal bilinguals made semantic relatedness decisions for pairs of English words. Half of the semantically unrelated pairs had phonologically related translations in American Sign Language (ASL). As in previous studies with unimodal bilinguals, targets in pairs with ...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2017.03.004
更新日期：2017-07-01 00:00:00
abstract：:Seven severely nonfluent aphasics and one relative or close friend were investigated in an interview situation. The conversation was videotaped and analyzed for the use of nonverbal communication between aphasic and partner. The results indicate that the group of aphasics used significantly more frequently and for a s...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(88)90053-3
更新日期：1988-01-01 00:00:00
abstract：:In this study, we investigated whether the left and right hemispheres are differentially involved in causal inference generation. Participants read short inference-promoting texts that described either familiar or less-familiar scenarios. After each text, they performed a lexical decision on a letter string (which som...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2005.03.005
更新日期：2005-12-01 00:00:00
abstract：:Naming treatment outcomes in post-stroke aphasia are variable and the factors underlying this variability are incompletely understood. In this study, 26 patients with chronic aphasia completed a semantic judgment fMRI task before receiving up to 12 weeks of naming treatment. Global (i.e., network-wide) and local (i.e....
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2020.104809
更新日期：2020-08-01 00:00:00
abstract：:Using a cross-modal semantic priming paradigm, the present study investigated the ability of left-hemisphere-damaged (LHD) nonfluent aphasic, right-hemisphere-damaged (RHD) and non-brain-damaged (NBD) control subjects to use local sentence context information to resolve lexically ambiguous words. Critical sentences we...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/s0093-934x(03)00072-5
更新日期：2003-06-01 00:00:00
abstract：:Aphasic patients with restricted memory spans were assessed on their comprehension of syntactically simple sentences varying in numbers of content words and on their comprehension of sentences matched in content words but varying in syntactic complexity. Three different presentation modes were used: unlimited visual p...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(90)90099-3
更新日期：1990-01-01 00:00:00
abstract：:We investigated whether left-hemisphere arachnoid cysts lead to reorganization of the language function using PET. A group analysis demonstrated that patients showed no more right-hemisphere activation than a matched control group. Several patients had clear language localizations in the left hemisphere during languag...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.2000.2358
更新日期：2000-12-01 00:00:00
abstract：:In three experiments, cost-benefit analysis was used to determine the role of attention in the processing of auditory information. In two experiments consonant-vowel syllables were presented monaurally, while in the third the mode of presentation was dichotic. For all three experiments the ability to detect a target s...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(88)90103-4
更新日期：1988-09-01 00:00:00
abstract：:Ninety-one adult aphasics of both sexes were studied before and after a 3-month period of language therapy. Although no initial sex difference was found in severity of language disorders, females within the global aphasic group showed significantly greater improvement in three tests of language comprehension. It is su...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(85)90081-1
更新日期：1985-07-01 00:00:00
abstract：:The question of whether lexical access for proper names is more impaired by ageing than lexical acess for other words is controversial. The aim of the present investigation was to evaluate the effect of age on proper and common name retrieval in long-term memory. The word retrieval paradigm used to achieve this goal c...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.2001.2515
更新日期：2002-04-01 00:00:00
abstract：:This paper presents a subject with a selective verb retrieval deficit. Nouns were produced more successfully than verbs in spontaneous speech, picture naming and when naming to definition. The word class effect was not observed in comprehension tasks, reading aloud or writing. This indicated that it was due to a speci...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.1998.1949
更新日期：1998-06-15 00:00:00
abstract：:In a simple prime-target visual rhyming paradigm, pairs of words, nonwords, and single letters elicited similar event-related potential (ERP) rhyming effects in young adults. Within each condition, primes elicited contingent negative variation (CNV) while nonrhyming targets elicited more negative waveforms than rhymin...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2007.06.003
更新日期：2008-03-01 00:00:00
abstract：:Neurolinguistic research has been engaged in evaluating models of language using measures from brain structure and function, and/or in investigating brain structure and function with respect to language representation using proposed models of language. While the aphasiological strategy, which classifies aphasias based...
journal_title：Brain and language
pub_type： 杂志文章,评审
doi：10.1016/j.bandl.2006.05.006
更新日期：2006-09-01 00:00:00
abstract：:Semantic knowledge has thematic relations of contiguity based on association and taxonomic relations of similarity based on shared features to form categories. It is unknown if there are distinct brain networks between thematic and taxonomic organizations in children and if this distinction is related to changes in sp...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2018.12.006
更新日期：2019-02-01 00:00:00
abstract：:Rapid, automatic access to lexical/semantic knowledge is critical in supporting the tight temporal constraints of on-line sentence comprehension. Based on findings of "abnormal" lexical priming in nonfluent aphasics, the question of disrupted automatic lexical activation has been the focus of many recent efforts to un...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.1997.1751
更新日期：1997-10-01 00:00:00
abstract：:A speculative neuronal model for vowel normalization and representation is offered. The neurophysiological basis for the premise is the "combination-sensitive" neuron recently documented in the auditory cortex of the mustached bat (N. Suga, W. E. O'Neill, K. Kujirai, and T. Manabe, 1983, Journal of Neurophysiology, 49...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(86)90087-8
更新日期：1986-05-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章,评审
doi：10.1016/j.bandl.2015.01.003
更新日期：2015-09-01 00:00:00
abstract：:Mutism following brain trauma is quite common, is usually transient, and recovery of speech is essentially the rule. Lasting total absence of speech without aphasia is highly unusual. Three such patients, two of traumatic and one due to vascular origin showing buccofacial apraxia (BFA) and computerized tomography (CT)...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(88)90129-0
更新日期：1988-05-01 00:00:00
abstract：:The role of spelling-to-sound correspondence rules in oral word reading was investigated by asking patients with Alzheimer's Disease (AD) and normal controls to read aloud pronounceable letter strings that do not happen to be real words. These pseudowords were of two types: those that have orthographically similar "ne...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(92)90109-r
更新日期：1992-10-01 00:00:00
abstract：:Published 100 years ago, Freud's monograph on aphasia, Zur Auffassung der Aphasien, is an incisive analysis of the so-called diagram-makers, those aphasiologists who would reduce brain and language to simple schemes of circumscribed cortical centers linked by unidirectional subcortical pathways. Chief architects of th...
journal_title：Brain and language
pub_type： 传,历史文章,杂志文章
doi：10.1016/0093-934x(92)90019-b
更新日期：1992-07-01 00:00:00
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journal_title：Brain and language
pub_type： 杂志文章,评审
doi：10.1016/j.bandl.2006.04.016
更新日期：2007-08-01 00:00:00
abstract：:The left angular gyrus has long been implicated in semantic processing. Here we tested whether or not transcranial direct current stimulation (tDCS) over the left angular gyrus modulated reading performance. Adult readers (N = 77) (1) read aloud words that varied in degree of imageability, a semantic word property kno...
journal_title：Brain and language
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bandl.2018.11.002
更新日期：2019-01-01 00:00:00
abstract：:Coney (1998) used a priming procedure to obtain evidence that the left and right hemispheres contributed equally to lexical processing of concrete nouns in a continuous reading task. In that study, however, there was no direct validation of the involvement of the right hemisphere in the task, and the possibility of le...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1006/brln.2001.2497
更新日期：2002-02-01 00:00:00
abstract：:According to our clinical observations from various aspects of stroke patients, such as the total incidence of aphasia, the incidence of aphasia after left brain damage of the dextrals, the aphasia that occurs in patients without hemiplegia, and the types of aphasia, a much higher incidence of crossed aphasia is seen ...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(90)90144-6
更新日期：1990-10-01 00:00:00
abstract：:We report the performance of two aphasic patients in a morphological transformation task. Both patients are Spanish-Catalan bilingual speakers who were diagnosed with agrammatic Broca's aphasia. In the morphological transformation task, the two patients were asked to produce regular and irregular verb forms. The patie...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/j.bandl.2004.02.007
更新日期：2004-11-01 00:00:00
abstract：:The understanding of stories requires sensitivity to structural aspects of narrative, the emotional content conveyed by the narrative, and the interaction between structural and emotional facets of the story. Right-hemisphere-damaged (RHD) and normal control subjects performed a number of different analytic tasks whic...
journal_title：Brain and language
pub_type： 杂志文章
doi：10.1016/0093-934x(92)90104-m
更新日期：1992-04-01 00:00:00
