Abstract：
:Biological characteristics and estrogen (ER) and progesterone (PR) receptors were studied in male mammary carcinomas induced by 7,12-dimethylbenz(a)anthracene (DMBA) in male inbred Sprague-Dawley rats (MM). DMBA-induced carcinomas in females (MF) were used as controls. In 36 of 44 female rats given 20 mg DMBA once by gastric intubation at 50 days of age, MF with microscopic characteristics of cystic papillary adenocarcinoma developed 124 +/- 49 (S.D.) days after challenge. In all of the 42 male rats given 10 mg DMBA at 14-day intervals for 14 weeks starting from 28 days of age. MM with microscopic characteristics of medullary adenocarcinoma developed 106 +/- 21 days after the first intubation of DMBA. The growth of primary MM was unaffected by orchiectomy or estrogen. Eighty to 100% of the MM transplanted in the four groups could grow in intact female rats, ovariectomized female rats, intact male rats, and castrated male rats, while the transplanted MF could grow only in intact female rats. The histology of MM was unchanged in primary and transplanted tumors under various hormonal conditions. ER were present in almost all of the hormone-independent primary and transplanted MM, although the levels for cytosol ER in MM were significantly lower than those in MF. Injection of 10 micrograms 17 beta-estradiol induced marked synthesis of PR in primary and transplanted MM, even 24 and 48 hr after the 17 beta-estradiol injection. These findings show that MM are hormone independent but, like hormone-dependent female tumors, contain ER and estrogen-dependent PR.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Yoshida H,Yoshida A,Fukunishi R,Sato B,Okamoto S,Matsumoto Ksubject
Has Abstractpub_date
1982-06-01 00:00:00pages
2434-9issue
6eissn
0008-5472issn
1538-7445journal_volume
42pub_type
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