Abstract：
:Biochemical, radiological and histological indicators of dialysis bone disease were studied before, 6 months (58 patients) and 12 months (48 patients) after starting treatment with 1 alpha-OH D3. Radiographic healing of subperiosteal erosions was seen after 6 months in 60% and after 12 months in 77% of affected patients. Radiographic improvement, however, was not significantly related to reductions in resorptive surfaces seen on quantitative bone histology, nor to changes in plasma concentrations of immunoreactive parathyroid hormone. Metastatic calcification appeared or increased in 43% of patients after 6 months and 52% after 12 months. Periosteal new bone developed or increased in 14% of patients after 6 months and 17% after 12 months. Both metastatic calcification and periosteal new bone formation were associated with high plasma phosphate concentrations, but not with plasma calcium, alkaline phosphatase or parathyroid hormone concentrations. Treatment with 1 alpha-OH D3 produces radiological improvement in the majority of patients with dialysis bone disease, but the lack of correlation with histological changes confirms the need for regular radiographic examination. Metastatic calcification and periosteal new bone formation probably represent toxicity of 1 alpha-OH D3 but may be minimised by phosphate restriction.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Robinson PJ,Walker GS,Peacock M,McLachlan MS,Davison AMdoi
10.1016/s0009-9260(82)80330-9subject
Has Abstractpub_date
1982-01-01 00:00:00pages
9-17issue
1eissn
0009-9260issn
1365-229Xpii
S0009-9260(82)80330-9journal_volume
33pub_type
杂志文章abstract：AIM:To evaluate the diagnostic performance of dual-energy computed tomography (DECT) using the virtual non-calcium (VNCa) technique for the detection of different degrees of vertebral bone marrow oedema. MATERIALS AND METHODS:The present prospective study was approved by the institutional ethics committee. Informed co...
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pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2004-02-01 00:00:00
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更新日期：2008-12-01 00:00:00
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更新日期：1989-09-01 00:00:00
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pub_type： 杂志文章
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