Abstract:
AIM:To determine the most accurate and reproducible semi-automated greyscale thresholding technique for quantifying late gadolinium enhancement (LGE) in cardiovascular magnetic resonance imaging (CMRI), by using positron-emission tomography (PET) as the reference standard in patients with coronary artery chronic total occlusion (CTO). MATERIALS AND METHODS:LGE in CMRI, single-photon-emission computed tomography (SPECT), and PET were performed within 1 week in each of 63 patients with known CTO. The presence and quantity of LGE were determined with greyscale thresholds of 2, 4, 5, 6, and 8 standard deviations (SDs) above the mean signal intensity for normal remote myocardium and full width at half maximum (FWHM). The infarcted myocardium was delineated by PET. RESULTS:Sixty-three patients and 1,008 segments were analysed. Based on patient analysis, with PET as the reference standard, the 5 SD method yielded the strongest correlation (r=0.85, p<0.0001) compared with the 2 SDs (r=0.42), 4 SDs (r=0.73), 6 SDs (r=0.81), 8 SDs (r=0.71), and FWHM (r=0.69; p<0.001 for all comparisons). The 5 SDs threshold quantification showed high interobserver and intra-observer agreement (intraclass correlation coefficient [ICC]=0.90, p<0.0001; ICC=0.93, p<0.0001, respectively). CONCLUSIONS:Semi-automated LGE CMRI greyscale thresholding with 5 SDs above the mean signal intensity for normal remote myocardium yields the strongest correlation to the extent of LGE identified using PET and is highly reproducible in patients with CTO.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Zhang LJ,Dong W,Li JN,Mi HZ,Jiao J,Dou RY,An J,Liu JL,He Y,Song XTdoi
10.1016/j.crad.2020.03.032subject
Has Abstractpub_date
2020-08-01 00:00:00pages
643.e19-643.e26issue
8eissn
0009-9260issn
1365-229Xpii
S0009-9260(20)30136-7journal_volume
75pub_type
杂志文章abstract::Antenatal diagnosis of lung abnormalities by ultrasound has been a much more frequent occurrence in recent years. There is a range of appearances from uniform increased echogenicity through to lesions containing large echo-free areas. Bilateral uniformly increased echogenicity has a poor outlook but in all other situa...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/s0009-9260(98)80188-8
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abstract::The incidence of bone metastases secondary to adenocarcinoma of the exocrine pancreas is unknown since radiological studies of the bones during life, routine bone scintigrams or extensive examination of the skeleton at autopsy is rarely undertaken in the absence of specific clinical indications. Symptom-producing bone...
journal_title:Clinical radiology
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doi:10.1016/s0009-9260(78)80162-7
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abstract::The use of computers is increasing in every field of medicine, especially radiology. Filmless radiology departments, speech recognition software, electronic request forms and teleradiology are some of the recent developments that have substantially increased the amount of time a radiologist spends in front of a comput...
journal_title:Clinical radiology
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doi:10.1016/j.crad.2008.08.003
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abstract::Major trauma services in England are currently undergoing a radical overhaul with the formation of regional trauma networks and designated major trauma centres (MTCs). Radiology is scheduled to play a key role within major trauma care both in terms of 24/7 access to whole body computed tomography (WBCT) and interventi...
journal_title:Clinical radiology
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abstract::Progeria or 'prematurely old' is an autosomal recessive trait that appears insidiously at or after the age of 6 months. Two affected siblings are reported showing radiologically progressive attenuation of the clavicles and terminal phalanges, widening of cranial sutures and mandibular hypoplasia. Scleroderma was also ...
journal_title:Clinical radiology
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journal_title:Clinical radiology
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(77)80062-7
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journal_title:Clinical radiology
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journal_title:Clinical radiology
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journal_title:Clinical radiology
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doi:10.1016/s0009-9260(76)80160-2
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journal_title:Clinical radiology
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doi:10.1016/j.crad.2004.03.003
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(81)80150-x
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journal_title:Clinical radiology
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journal_title:Clinical radiology
pub_type: 杂志文章,评审
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更新日期:1998-08-01 00:00:00
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journal_title:Clinical radiology
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doi:10.1016/s0009-9260(76)80099-2
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journal_title:Clinical radiology
pub_type: 杂志文章
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更新日期:1978-03-01 00:00:00
abstract::Of 167 patients with Hodgkin's disease seen in a single centre between December 1972 and December 1982, only one has developed a myelodysplastic state. Between 1972 and 1977, therapy consisted of radiotherapy alone for early-stage disease, combined-modality treatment for intermediate-stage disease and chemotherapy alo...
journal_title:Clinical radiology
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journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2012.10.020
更新日期:2013-06-01 00:00:00