Effect of mineralocorticoids on collecting duct hydrogen ion secretion in the rabbit.

abstract：:Newborn hearts have restricted functional reserve and variable responsiveness to inotropes that could be partly due to differences in myocardial beta-adrenoceptors (beta-AR). To clarify this issue, this study documented ventricle-specific changes in myocardial beta-AR density and affinity during postnatal maturation. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wittnich C,Belanger MP,Bandali K

更新日期：2006-08-01 00:00:00

abstract：:Rats were fed on a diet containing 1% beta-guanidinopropionate (Gp) to deplete their muscles of creatine. The apparent energy reserves (creatine phosphate (CrP) + ATP) of rested state diaphragm muscle strips were found to be 79% depleted by this treatment. To determine if the effective energy reserves for contraction ...

journal_title：Canadian journal of physiology and pharmacology

authors： Mainwood GW,Alward M,Eiselt B

更新日期：1982-02-01 00:00:00

abstract：:The pHi regulation from intracellular acidosis in the central nervous system appears to be mediated by mechanisms driven by the large inwardly directed Na+ gradient. The involvement of these mechanisms in pHi regulation of neurones and glial cells has been investigated in the leech central nervous system using ion-sel...

journal_title：Canadian journal of physiology and pharmacology

authors： Schlue WR,Dörner R

更新日期：1992-01-01 00:00:00

abstract：:At a critical premature interval, atrial premature beats encounter sinus node refractoriness and are blocked on entering and fail to reset the sinus node, resulting in interpolation of the premature beat. The transition from reset to interpolated response has been used to define the effective refractory period of the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Kerr CR

更新日期：1989-10-01 00:00:00

abstract：:The kinetics of sodium gradient dependent phosphate uptake by the renal brush border membrane vesicles of the rat have ben studied under various conditions of temperature and pH. From 7 to 30 degrees C the Lineweaver-Burk plots are linear, and the apparent Km progressively increases from 54 to 91 microM. Above 30 degr...

journal_title：Canadian journal of physiology and pharmacology

authors： Brunette MG,Beliveau R,Chan M

更新日期：1984-02-01 00:00:00

abstract：:In order to understand the mechanisms of exercise intolerance and muscle fatigue, which are commonly observed in congestive heart failure, we studied sarcoplasmic reticulum (SR) Ca(2+)-transport in the hind-leg skeletal muscle of rats subjected to myocardial infarction (MI). Sham-operated animals were used for compari...

journal_title：Canadian journal of physiology and pharmacology

authors： Shah KR,Ganguly PK,Netticadan T,Arneja AS,Dhalla NS

更新日期：2004-07-01 00:00:00

abstract：:Natural rodent grooming and other instinctive behavior serves as a natural model of complex movement sequences. Rodent grooming has syntactic (rule-driven) sequences and more random movement patterns. Both incorporate the same movements--only the serial structure differs. Recordings of neural activity in the dorsolate...

journal_title：Canadian journal of physiology and pharmacology

authors： Aldridge JW,Berridge KC,Rosen AR

更新日期：2004-08-01 00:00:00

abstract：:Hereditary muscular hypertrophy is a character that has been selected in several animal species for industrial meat production. The selection of this character in cattle produces animals of exceptional commercial value but ones with a lower aerobic capacity than that of conventional cattle. The purpose of this work wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Amory H,McEntee K,Linden AS,Desmecht DJ,Beduin JM,D'Orio V,Lekeux PM

更新日期：1993-12-01 00:00:00

abstract：:The purpose of this study was to compare the specific cortisol-binding protein found associated with human amnion with specific cortisol binding in human amniotic fluid and plasma. The electrophoretic mobility on polyacrylamide gels of the specific cortisol binding in amnion, amniotic fluid, and maternal plasma was id...

journal_title：Canadian journal of physiology and pharmacology

authors： Riopel L,Gibb W

更新日期：1987-01-01 00:00:00

abstract：:Adult rats treated with high doses of streptozocin became progressively more hyperglycemic during the first month of the diabetic condition. Treatment of these rats with the sulfonylurea glyburide halted, and in some cases, reversed this process in a high percentage of the diabetics. Associated with the glyburide-medi...

journal_title：Canadian journal of physiology and pharmacology

authors： Mozaffari MS,Wilson GL,Schaffer SW

更新日期：1988-12-01 00:00:00

abstract：:Glycine has been used to reduce oxidative stress and proinflammatory mediators in some metabolic disorders; however, its effect on the vasculature has been poorly studied. The aim of this work was to explore the effect of glycine on endothelial dysfunction in aged rats. Aortic rings with intact or denuded endothelium ...

journal_title：Canadian journal of physiology and pharmacology

authors： Gómez-Zamudio JH,García-Macedo R,Lázaro-Suárez M,Ibarra-Barajas M,Kumate J,Cruz M

更新日期：2015-06-01 00:00:00

abstract：:Rats fed a polychlorinated biphenyl (PCB) mixture in a high- or low-iodine diet (HID or LID respectively) for 15 days had thyroid enlargement, low serum thyroxine (T4), and high serum thyrotropin concentrations. Although binding of thyroid hormones to serum proteins was reduced in PCB-fed animals, the free T4 index (r...

journal_title：Canadian journal of physiology and pharmacology

authors： Bastomsky CH

更新日期：1977-04-01 00:00:00

abstract：:Wound healing is important for longevity. Midkine is a cytokine involved in controlling tissue repair and new tissue development, and in regulating inflammation. We investigated the effect of midkine on wound healing in rats. In total, 108 Wistar albino rats were used: 12 as healthy and diabetic controls; 96 were spli...

journal_title：Canadian journal of physiology and pharmacology

authors： Dik B,Baş AL,Yazıhan N

更新日期：2017-05-01 00:00:00

abstract：:Recent lines of evidence suggest that the beneficial effects of olive oil are not only related to its high content of oleic acid, but also to the antioxidant potential of its polyphenols. The aim of this work was determine the effects of olive oil and its components, oleic acid and the polyphenol dihydroxyphenylethano...

journal_title：Canadian journal of physiology and pharmacology

authors： Faine LA,Rodrigues HG,Galhardi CM,Ebaid GM,Diniz YS,Padovani CR,Novelli EL

更新日期：2006-02-01 00:00:00

abstract：:NTPDase is one of the principal enzymes involved in the sequential hydrolysis of ATP. In the present study, the presence and functionality of NTPDase in the mesenteric vein and artery were examined. Adenosine triphosphate (ATP) (0.01-1000 pmol) induces a dose-dependent vasodilation in the isolated arterial and venous ...

journal_title：Canadian journal of physiology and pharmacology

authors： Duval M,Beaudoin AR,Bkaily G,Gendron FP,D' Orléans-Juste P

更新日期：2003-03-01 00:00:00

abstract：:Cumulative data suggest the significant role of the renin-angiotensin system in the development of the pathological consequences of diabetes mellitus (DM). Newly synthesized AT2 receptor agonists gained importance as a target for creating new antihypertensives. The aim of the present work was to study the effects of p...

journal_title：Canadian journal of physiology and pharmacology

authors： Pechlivanova D,Petrov K,Grozdanov P,Nenchovska Z,Tchekalarova J,Stoynev A

更新日期：2018-05-01 00:00:00

abstract：:D-Serine, a recently identified gliotransmitter, serves as an endogenous coagonist binding to the glycine site of N-methyl-D-aspartate (NMDA) receptors. However, it is not clear whether this native ligand is able to bind to and modulate alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (AMPA) receptors. In the pre...

journal_title：Canadian journal of physiology and pharmacology

authors： Gong XQ,Zabek RL,Bai D

更新日期：2007-05-01 00:00:00

abstract：:Opioid and N-methyl-d-aspartate (NMDA) receptors mediate different effects of fluoxetine. We investigated whether opioid and NMDA receptors are involved in the protective effect of fluoxetine against the behavioral despair induced by acute physical stress in male mice. We used the forced swimming test (FST), tail susp...

journal_title：Canadian journal of physiology and pharmacology

authors： Haj-Mirzaian A,Kordjazy N,Ostadhadi S,Amiri S,Haj-Mirzaian A,Dehpour A

更新日期：2016-06-01 00:00:00

abstract：:This review presents, from the author's viewpoint, avenues of histamine research likely to produce new information. One potentially useful approach may be to attempt to relate histamine's function to its occurrence in different body tissues such as the pituitary and hypothalamus, the gastrointestinal mucosa, and the b...

journal_title：Canadian journal of physiology and pharmacology

authors： Code CF

更新日期：1985-06-01 00:00:00

abstract：:In Sprague-Dawley rats, we attempted to develop an experimental model to stimulate the cardiac sympathetic nerve. After transverse thoracotomy under anesthesia, a miniature, bipolar electrode was placed on the right ansa subclavia and it was stimulated electrically. The nerve stimulation at 2, 4, and 8.3 Hz (2 ms in d...

journal_title：Canadian journal of physiology and pharmacology

authors： Masuda Y,Matsuoka H

更新日期：1997-02-01 00:00:00

abstract：:Spironolactone at 10 mg per kilogram per day was given to control and 'one-kidney-one-clip' hypertensive dogs for 6--7 weeks. Compared with untreated animals the treated animals had a lower arterial water content, a higher arterial, myocardial, and skeletal muscle sodium content, and variable changes in tissue potassi...

journal_title：Canadian journal of physiology and pharmacology

authors： Constantopoulos G,Gutkowska J,Genest J

更新日期：1979-06-01 00:00:00

abstract：:The goal of the present study was to investigate the formation of portacaval shunts in a new experimental model of chronic portal hypertension, portal vein stenosis in the cat. The procedure gradually occluded the portal vein by use of an Ameroid constrictor around the portal vein. After 4 weeks, the portal vein was c...

journal_title：Canadian journal of physiology and pharmacology

authors： Inglés AC,Légaré DJ,Lautt WW

更新日期：1993-09-01 00:00:00

abstract：:In using pharmacologic stimuli, force-velocity (FV) curves are usually obtained by the method of quick release (QR) and redevelopment of shortening at peak tetanic tension; the advantage of the method being that the active state is at maximum. However, the QR may itself reduce the intensity of the active state and res...

journal_title：Canadian journal of physiology and pharmacology

authors： Stephens NL

更新日期：1985-01-01 00:00:00

abstract：:The effects of magnesium (from 1.2 to 7.2 mM) were investigated in isolated perfused rat heart subjected to coronary artery ligation and reperfusion. Increasing magnesium concentrations, of the medium containing 3.00 mM of calcium, induced a significant bradycardia and a protective effect towards reperfusion arrhythmi...

journal_title：Canadian journal of physiology and pharmacology

authors： Bril A,Rochette L

更新日期：1990-06-01 00:00:00

abstract：:A new antagonist of the vasoconstrictor eicosanoids, L-640,035, was studied in a standardized model of myocardial ischemia (MI) in anesthetized cats. This eicosanoid antagonist was not found to exert any overt hemodynamic action in cats subjected to a sham myocardial ischemia protocol. However, the antagonist markedly...

journal_title：Canadian journal of physiology and pharmacology

authors： Lefer AM,Burke SE,Lepran I

更新日期：1984-12-01 00:00:00

abstract：:Experiments in right atria isolated from adult male rats were designed to determine which of the alpha 1-adrenergic receptor (alpha 1-AR) subtypes are involved in the positive chronotropic effect of phenylephrine, an alpha 1-AR agonist. Chloroethylclonidine (CEC), an irreversible alpha 1b-, alpha 1c-, and alpha 1d-AR ...

journal_title：Canadian journal of physiology and pharmacology

authors： Williamson AP,Seifen E,Lindemann JP,Kennedy RH

更新日期：1994-12-01 00:00:00

abstract：:Intrinsic regulation of hepatic blood flow is mediated only through the hepatic artery because the liver is not able to directly regulate portal vein blood flow. Hepatic metabolic activity does not affect hepatic artery flow. Although the hepatic artery is affected by sympathetic nerves and blood-borne agents, the int...

journal_title：Canadian journal of physiology and pharmacology

authors： Lautt WW

更新日期：1996-03-01 00:00:00

abstract：:Negative chronotropic effects of beta-adrenoceptor (betaAR) antagonists on right atria from reserpine-treated rats and mice were determined as a test of their inverse agonist activities. BetaAR antagonist ICI-118,551 and nonselective betaAR antagonists alprenolol, propranolol, and timolol produced negative chronotropi...

journal_title：Canadian journal of physiology and pharmacology

authors： Varma DR

更新日期：1999-12-01 00:00:00

abstract：:Acrolein, a highly reactive alpha,beta-unsaturated aldehyde, is an omnipresent environmental pollutant. Chronic and acute human exposures occur through exogenous and endogenous sources, including food, vapors of overheated cooking oil, house and forest fires, cigarette smoke, and automobile exhaust. Acrolein is a toxi...

journal_title：Canadian journal of physiology and pharmacology

authors： Roy J,Pallepati P,Bettaieb A,Averill-Bates DA

更新日期：2010-03-01 00:00:00

abstract：:Changes in estrogen production are considered important in the sequence of events leading to parturition. We sought tissue-specific changes in the concentration of unconjugated estrone (E1) and estradiol (E2) in intrauterine fetal (amnion, chorion) and maternal (endometrium, myometrium) tissues during normal pregnancy...

journal_title：Canadian journal of physiology and pharmacology

authors： Power SG,Challis JR

更新日期：1987-02-01 00:00:00