The effects of metabolic inhibitors on the contraction of creatine-depleted muscle.

abstract：:The effects of haloperidol, an antipsychotic butyrophenone, on excitability and action potential production in frog's sartorius muscle fibers were studied. This drug produced a local-anestheticlike effect which developed slowly over 1 to 5 h with lower concentrations (2.7 to 5.3 X 10(-6 M) but was completely reversed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Durham HD,Frank GB,Marwaha J

更新日期：1977-06-01 00:00:00

abstract：:In the mesenteric circulation of the rat a myogenic autoregulatory system operates at 0.1-0.15 Hz. Negative admittance phase in the region above 0.2 Hz suggested operation of an arterial baroreflex. The present study was designed to test this interpretation and to identify the neurotransmitter involved. In rats anesth...

journal_title：Canadian journal of physiology and pharmacology

authors： Abu-Amarah I,Cupples WA

更新日期：2000-01-01 00:00:00

abstract：:The effects of beta-cyclodextrin (betaCD) inclusion complexation on the ability of violacein to prevent gastric ulceration in mice were studied. Violacein-betaCD inclusion complexes were prepared in 1:1 and 1:2 molar ratios and analysed by differential scanning calorimetry and powder X-ray diffractometry. Violacein pr...

journal_title：Canadian journal of physiology and pharmacology

authors： Durán N,Justo GZ,Melo PS,De Azevedo MB,Brito AR,Almeida AB,Haun M

更新日期：2003-04-01 00:00:00

abstract：:Administration of d-fenfluramine, a serotonin-releasing drug, to male rats induced a dose-dependent increase in both serum prolactin and corticosterone concentrations. Serum growth hormone levels increased, but not significantly, at a dose of 1.25 mg/kg i.p. and decreased significantly at higher doses. When rats were ...

journal_title：Canadian journal of physiology and pharmacology

authors： Serri O,Rasio E

更新日期：1987-12-01 00:00:00

abstract：:We examined the effects of long-term streptozotocin (STZ) diabetes and its treatment by intensive insulin therapy (IIT) or pancreatic islet transplantation on pulmonary pressor and depressor responses and segmental resistance profiles in female Wistar-Furth rats. Pulmonary vascular reactivity was examined using isolat...

journal_title：Canadian journal of physiology and pharmacology

authors： Russ RD,Tobin BW

更新日期：1998-04-01 00:00:00

abstract：:Microelectrode and mechanical studies were performed with isolated guinea pig myocardium (right ventricular free walls and papillary muscles) to examine the effects of platelet-activating factor (PAF) and lysophosphatidylcholine (LPC). Low concentrations of PAF (10(-8) to 10(-6) M, a range equivalent to the blood conc...

journal_title：Canadian journal of physiology and pharmacology

authors： Shigenobu K,Mori T,Kamata K,Kasuya Y

更新日期：1989-06-01 00:00:00

abstract：:Cyclic AMP response element (CRE) binding protein (CREB) is a nuclear transcription factor that regulates the transcription of several genes containing the CRE sites on their promoters. CREB is activated by phosphorylation on a key serine residue, Ser311, in response to a wide variety of extracellular stimuli includin...

journal_title：Canadian journal of physiology and pharmacology

authors： Truong V,Anand-Srivastava MB,Srivastava AK

更新日期：2021-01-01 00:00:00

abstract：:Using immunofluorescence and real 3-D confocal microscopy, our results showed the presence of ET-1, ETA, and ETB receptors in isolated human aortic vascular endothelial cells (hVECs). The level of the peptide and its receptors was significantly higher in the nucleus (including the nuclear envelope membranes) than in t...

journal_title：Canadian journal of physiology and pharmacology

authors： Avedanian L,Riopel J,Bkaily G,Nader M,D'Orleans-Juste P,Jacques D

更新日期：2010-08-01 00:00:00

abstract：:The validity of a Hodgkin-Huxley type voltage-dependent inactivation of slow inward Ca current (Isi) was tested in frog heart using a computer simulation. The time course of Isi was calculated during the development of a frog atrial action potential (AP). With a time constant of inactivation (tauf) of 55 ms at a membr...

journal_title：Canadian journal of physiology and pharmacology

authors： Fischmeister R,Horackova M

更新日期：1982-09-01 00:00:00

abstract：:Endothelin-1 has emerged as an important participant in the pathophysiology of a variety of cardiovascular diseases, where it may act on endocrine, paracrine and autocrine bases. Here we review its regulated biosynthesis, receptor-mediated signaling, and functional consequences in the heart, with particular emphasis o...

journal_title：Canadian journal of physiology and pharmacology

authors： Yang LL,Arab S,Liu P,Stewart DJ,Husain M

更新日期：2005-01-01 00:00:00

abstract：:The effect of various doses of i.p. injection of the adenosine receptor agonist (R)-phenylisopropyladenosine (R-PIA), ranging from nanomolar to micromolar concentrations, on plasma levels of free fatty acids, glucose, insulin, glucagon, ACTH, and corticosterone was examined in 200-g male rats. At the lowest dose of R-...

journal_title：Canadian journal of physiology and pharmacology

authors： LeBlanc J,Soucy J

更新日期：1994-02-01 00:00:00

abstract：:In this study, we aimed to investigate the protective effects of androgens, using letrozole (LET; an aromatase inhibitor), grape seed extract (GSE; a naturally occurring aromatase inhibitor and antioxidant), and testosterone propionate (Tp), against methotrexate (MTX)-induced testicular toxicity in adult male rats. MT...

journal_title：Canadian journal of physiology and pharmacology

authors： Makary S,Abdo M,Fekry E

更新日期：2018-04-01 00:00:00

abstract：:Physical activity promotes metabolic adaptations that improve body functionality and contribute to the prevention of some diseases. With respect to energy and fat balance, physical activity facilitates the equilibrium between energy intake and expenditure as well as between fat intake and fat oxidation. When combined ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tremblay A,Therrien F

更新日期：2006-02-01 00:00:00

abstract：:The purposes of this review were twofold: to apply modern physicochemical principles to explain changes in acid-base regulation and the control of ventilation in human pregnancy; and to demonstrate the value of pregnancy as a model for the study of endocrine effects on physiological control systems. Application of P.A...

journal_title：Canadian journal of physiology and pharmacology

authors： Wolfe LA,Kemp JG,Heenan AP,Preston RJ,Ohtake PJ

更新日期：1998-09-01 00:00:00

abstract：:The electrical activity of the duodenum and proximal jejunum was studied in conscious healthy dogs implanted with unipolar silver electrodes. A computerized method was used for the calculation of the mean frequency of the slow wave for each consecutive minute of the electromyographic signal. A "slow wave frequency com...

journal_title：Canadian journal of physiology and pharmacology

authors： Pousse A,Mendel C,Aprahamian M,Kachelhoffer J,Balboni G,Plas A

更新日期：1987-06-01 00:00:00

abstract：:The reported efficiencies of drug encapsulation into liposomes range from less than 0.1% to more than 10% per micromole phospholipid, depending on the nature of the drug and of the liposome employed. We have sought to investigate some of the factors which control the efficiency of drug encapsulation. We have found tha...

journal_title：Canadian journal of physiology and pharmacology

authors： Stamp D,Juliano RL

更新日期：1979-05-01 00:00:00

abstract：:The mesenteric vascular bed preparation of control and pinealectomized (PX) male Wistar rats was used to examine vascular reactivity to two concentrations each of norepinephrine, serotonin, angiotensin, and potassium. Vasoconstrictor responses to 50- and 100-ng injections of norepinephrine and 0.5- and 1.0-microgram i...

journal_title：Canadian journal of physiology and pharmacology

authors： Cunnane SC,Manku MS,Oka M,Horrobin DF

更新日期：1980-03-01 00:00:00

abstract：:The most commonly observed effect of beta-blockade on cardiovascular function has been a reduction in heart rate both at rest and during exercise. The body attempts to compensate by increasing stroke volume and (or) increasing the extraction of O2 from the blood to maintain O2 delivery to the muscle. This paper examin...

journal_title：Canadian journal of physiology and pharmacology

authors： Hughson RL,Kowalchuk JM

更新日期：1991-02-01 00:00:00

abstract：:The goal of the present study was to investigate the formation of portacaval shunts in a new experimental model of chronic portal hypertension, portal vein stenosis in the cat. The procedure gradually occluded the portal vein by use of an Ameroid constrictor around the portal vein. After 4 weeks, the portal vein was c...

journal_title：Canadian journal of physiology and pharmacology

authors： Inglés AC,Légaré DJ,Lautt WW

更新日期：1993-09-01 00:00:00

abstract：:The experiment examined biological responses produced by combined sequential exposure to low-level tritium contamination, followed by challenging irradiation with fast neutrons. Modifications of endogenous antioxidant potential of different organs in rats were discussed in relation to tissue radiosensitivity. Rats pre...

journal_title：Canadian journal of physiology and pharmacology

authors： Petcu I,Moisol N,Savu D,Constantinescu B

更新日期：2002-07-01 00:00:00

abstract：:An investigation was made of the radiosensitivity of the toxic and immunological properties of Androctonus australis hector venom. This venom was irradiated with two doses of gamma rays (1 and 2 kGy) from a 60Co source. The results showed that venom toxicity was abolished for the two radiation doses (1 and 2 kGy) with...

journal_title：Canadian journal of physiology and pharmacology

authors： Abib L,Laraba-Djebari F

更新日期：2003-12-01 00:00:00

abstract：:A method for the determination of the specific activity of plasma glycerol is described. Anionic contaminants are first removed from deproteinzed plasma by anionic exchange resins (treated plasma). Glycerol in treated plasma is then quantitatively converted to glycerol-3-phosphate (G3P), which is isolated by column ch...

journal_title：Canadian journal of physiology and pharmacology

authors： Gauthier C,Layberry R

更新日期：1982-06-01 00:00:00

abstract：:Perfusion of isolated rat hearts with Na-free medium resulted in an immediate increase in contractile force followed by a decline and complete loss of contractile force within 25 s. The recovery of the contractile force upon reperfusion was only partial if the duration of Na-free perfusions was 10 min or longer. Ca bi...

journal_title：Canadian journal of physiology and pharmacology

authors： Dhalla NS,Lee SL,Singal PK,Yates JC,Panagia V

更新日期：1980-12-01 00:00:00

abstract：:The combined and separate effects of exercise training and bisphosphonate (etidronate) therapy on bone mineral in postmenopausal women were compared. Forty-eight postmenopausal women were randomly assigned (double blind) to groups that took intermittent cyclical etidronate; performed strength training (3 d/week) and r...

journal_title：Canadian journal of physiology and pharmacology

authors： Chilibeck PD,Davison KS,Whiting SJ,Suzuki Y,Janzen CL,Peloso P

更新日期：2002-10-01 00:00:00

abstract：:The precise neurobiological mechanisms of tramadol abuse underlying the cognitive function are still unknown. The aim of the present study was to examine the possible effects of intra-CA1 injections of N-methyl-d-aspartate (NMDA), a glutamate NMDA receptor (NMDAR) agonist, and d,l-2-amino-5-phosphonopentanoic acid (DL...

journal_title：Canadian journal of physiology and pharmacology

authors： Jafari-Sabet M,Mofidi H,Attarian-Khosroshahi MS

更新日期：2018-01-01 00:00:00

abstract：:The force generated by tracheal spirals and lung parenchymal strips from normal and ovalbumin-sensitized guinea pigs was measured in vitro, after challenge with histamine, carbachol, leukotriene (LT) C4, LTD4, or a prostaglandin endoperoxide analog (U-44069). The responses and sensitivity of airway tissues to the abov...

journal_title：Canadian journal of physiology and pharmacology

authors： Saad MH,Burka JF

更新日期：1983-08-01 00:00:00

abstract：:The purpose of this study was to characterize the biological activity of the synthetic rat growth hormone releasing factor analogue rGRF(1-29)NH2 and to compare its action on growth hormone (GH) release to that of authentic rGRF(1-43)OH. We first compared the concentration-response characteristics of the two peptides ...

journal_title：Canadian journal of physiology and pharmacology

authors： Kraicer J,French MB,Lussier BT,Moor BC,Brazlan P

更新日期：1991-02-01 00:00:00

abstract：:Immunocytochemistry, radioimmunoassay, chromatography, and biological assay using a rabbit isolated duodenal muscle strip preparation were used in attempting to characterize motilin from the rat small intestine. Several different antisera and monoclonal antibodies directed against natural porcine motilin were used. A ...

journal_title：Canadian journal of physiology and pharmacology

authors： Vogel LB,Brown JC

更新日期：1990-08-01 00:00:00

abstract：:Dissociated neuronal cultures have become a popular tool to address a number of questions in neurobiology. These culture systems may provide useful paradigms to approach problems related to in vivo neurotoxicity of xenobiotics. The clinical spectra of vinca neurotoxicity and alcohol teratogenesis is reviewed, and some...

journal_title：Canadian journal of physiology and pharmacology

authors： Riopelle RJ,Dow KE,Eisenhauer E

更新日期：1984-08-01 00:00:00

abstract：:Kinins are the endogenous ligands of the constitutive B2 receptor (B2R) and the inducible B1 receptor (B1R). Whereas B2R prevents insulin resistance, B1R is involved in insulin resistance and metabolic syndrome. However, the contribution of B1R in type 2 diabetes associated with obesity remains uncertain. The aim of t...

journal_title：Canadian journal of physiology and pharmacology

authors： Talbot S,Dias JP,El Midaoui A,Couture R

更新日期：2016-07-01 00:00:00