Abstract：
:The objective of the present study was to investigate the treatment of 9L gliosarcoma brain tumor in the rat with the combination of surgical resection and photodynamic therapy (PDT). Nude rats with intracranial 7-day-old 9L gliomas were randomly subjected to no treatment, PDT alone (Photofrin: 2 mg kg(-1), optical: 80 J cm(-2)), surgical resection alone or resection combined with 2 mg kg(-1) Photofrin-mediated PDT at an optical dose of 80 J cm(-2). All animals were sacrificed 14 days after tumor implantation. Hematoxylin-and-eosin and immunohistochemical stainings were performed to assess the tumor volume and the expression of vascular endothelial growth factor (VEGF) in the brain adjacent to the tumor (BAT) as well as the tumor cell apoptosis and proliferation. Our data show that both surgical resection alone and PDT alone significantly decreased tumor volume, but furthermore, surgical resection combined with PDT significantly reduced the tumor volume and reduced local tumor infiltration compared to either surgical resection or PDT treatment alone. PDT treatment with or without resection increased tumor apoptosis, but resection alone did not alter the tumor cell apoptosis compared with a nontreatment control group. Both surgical resection alone and PDT alone induced a significant increase in VEGF expression in the BAT; however intraoperative PDT did not further increase VEGF expression, compared with surgery alone or PDT alone. No significant differences were found in tumor cell proliferation as indicated by Ki67 immunoreactivity among the four groups. Our results suggest that PDT enhances the efficacy of surgical resection in the management of malignant gliomas without increasing VEGF expression in the BAT.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
Zhang X,Jiang F,Kalkanis SN,Yang H,Zhang Z,Katakowski M,Hong X,Zheng X,Chopp Mdoi
10.1562/2006-06-16-RA-934subject
Has Abstractpub_date
2006-11-01 00:00:00pages
1704-11issue
6eissn
0031-8655issn
1751-1097pii
2006-06-16-RA-934journal_volume
82pub_type
杂志文章abstract：:Tissue inhibitors of metalloproteinases (TIMPs) are the major endogenous regulators of metalloproteinase activity in tissues. TIMPs are able to inhibit activity of all known matrix metalloproteinases (MMPs) and thus participate in controlling extracellular matrix synthesis and degradation. We showed previously elevate...
journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/php.12612
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abstract：:Photoisomerization of a protein-bound chromophore is the basis of light sensing and signaling in many photoreceptors. Phytochrome photoreceptors can be photoconverted reversibly between the Pr and Pfr states through photoisomerization of the methine bridge between rings C and D. Ground-state heterogeneity of the chrom...
journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/php.12743
更新日期：2017-05-01 00:00:00
abstract：:In this work, we have quantified for the first time the fluorescence and singlet oxygen quantum yields of a silicon(IV) phthalocyanine bound to the surface of zeolite L nanocrystals. The photophysical properties were correlated with the absorption spectra and the morphology of the nanoparticles, and most importantly, ...
journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/php.12141
更新日期：2013-11-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：
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abstract：:New thio- and seleno-analogs of psoralen were synthesized and analyzed for their photoreactivity toward DNA. Using oligonucleotides of defined sequence, we first showed that these derivatives predominantly generated interstrand crosslinks at 5'-TpA sites. We also observed a surprisingly high reactivity of 7H-thiopyran...
journal_title：Photochemistry and photobiology
pub_type： 杂志文章
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abstract：:Previous studies have shown that natural killer (NK) cell activity was suppressed in volunteer subjects exposed to ultraviolet radiation (UVR) from solarium lamps. The present studies were carried out to determine the spectrum of UVR responsible for suppression of NK activity and to develop in vitro methods to analyze...
journal_title：Photochemistry and photobiology
pub_type： 杂志文章
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abstract：:All-trans retinoic acid (ATRA) plays essential roles in the normal biological processes and the treatment of cancer and skin diseases. Considering its photosensitive property, many studies have been focused on the photochemistry of ATRA. In this study, we investigated the transient phenomena in the laser flash photoly...
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pub_type： 杂志文章
doi：10.1111/php.12128
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/j.1751-1097.1996.tb02460.x
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pub_type： 杂志文章
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1562/0031-8655(2000)071<0737:miamft>2.0.co;2
更新日期：2000-06-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/j.1751-1097.1995.tb08713.x
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
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更新日期：2002-09-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/php.12030
更新日期：2013-05-01 00:00:00
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doi：10.1111/php.13089
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/j.1751-1097.1994.tb09664.x
更新日期：1994-06-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1562/0031-8655(2001)074<0512:aotebb>2.0.co;2
更新日期：2001-10-01 00:00:00
abstract：:The retina and retinal pigment epithelium contain a number of retinoids in a metabolic pathway that eventually forms the visual pigments. This study investigates the photochemistry of those retinoids that may contribute to light-induced damage to the retina. These include retinal (RAL), retinol (ROL), retinylpalmitate...
journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/j.1751-1097.1996.tb05673.x
更新日期：1996-05-01 00:00:00
