Insulin stimulation of glycogen synthase in cultured human diploid fibroblasts.

abstract：OBJECTIVE:Physiologically elevated insulin concentrations promote access of macromolecules to skeletal muscle in dogs. We investigated whether insulin has a stimulating effect on the access of macromolecules to insulin-sensitive tissues in humans as well. RESEARCH DESIGN AND METHODS:In a randomized, controlled trial, ...

journal_title：Diabetes

authors： Weinhandl H,Pachler C,Mader JK,Ikeoka D,Mautner A,Falk A,Suppan M,Pieber TR,Ellmerer M

更新日期：2007-09-01 00:00:00

abstract：:An accelerated accumulation of advanced glycation end products (AGEs) occurs in diabetes secondary to the increased glycemic burden. In this study, we investigated the contribution of AGEs to intravascular oxidant stress by examining their action on the neutrophil burst of reactive oxygen species (ROS); this may be a ...

journal_title：Diabetes

authors： Wong RK,Pettit AI,Davies JE,Ng LL

更新日期：2002-09-01 00:00:00

abstract：:Rosiglitazone therapy improves insulin sensitivity and glucose uptake in patients with uncomplicated type 2 diabetes. In coronary artery disease (CAD), glucose is an important source of energy and preserved myocardial glucose uptake is essential for the viability of jeopardized myocardium. The aim was to test whether ...

journal_title：Diabetes

authors： Lautamäki R,Airaksinen KE,Seppänen M,Toikka J,Luotolahti M,Ball E,Borra R,Härkönen R,Iozzo P,Stewart M,Knuuti J,Nuutila P

更新日期：2005-09-01 00:00:00

abstract：:Glucose stimulates insulin secretion by generating triggering and amplifying signals in beta-cells. The triggering pathway is well characterized. It involves the following sequence of events: entry of glucose by facilitated diffusion, metabolism of glucose by oxidative glycolysis, rise in the ATP-to-ADP ratio, closure...

journal_title：Diabetes

authors： Henquin JC

更新日期：2000-11-01 00:00:00

abstract：:In type 2 diabetes, impaired insulin-induced Akt/endothelial nitric oxide synthase (eNOS) signaling may decrease the vascular relaxation response. Previously, we reported that this response was negatively regulated by G protein-coupled receptor kinase 2 (GRK2). In this study, we investigated whether/how in aortas from...

journal_title：Diabetes

authors： Taguchi K,Matsumoto T,Kamata K,Kobayashi T

更新日期：2012-08-01 00:00:00

abstract：:Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism and are also involved in glucose metabolism. However, the functional role of LXRs in human skeletal muscle is at present unknown. This study demonstrates that chronic ligand activation of LXRs by a synthetic LXR agonist increases the...

journal_title：Diabetes

authors： Kase ET,Wensaas AJ,Aas V,Højlund K,Levin K,Thoresen GH,Beck-Nielsen H,Rustan AC,Gaster M

更新日期：2005-04-01 00:00:00

abstract：:In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, an...

journal_title：Diabetes

authors： Feng Y,Niu T,Xu X,Chen C,Li Q,Qian R,Wang G,Xu X

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:The molecular mechanisms responsible for pancreatic β-cell dysfunction in type 2 diabetes remain unresolved. Increased expression of the helix-loop-helix protein Id1 has been found in islets of diabetic mice and in vitro models of β-cell dysfunction. Here, we investigated the role of Id1 in insulin secretion ...

journal_title：Diabetes

authors： Akerfeldt MC,Laybutt DR

更新日期：2011-10-01 00:00:00

abstract：:Production of reactive oxygen species (ROS) is a key instigator of β-cell dysfunction in diabetes. The pleiotropic cytokine interleukin 6 (IL-6) has previously been linked to β-cell autophagy but has not been studied in the context of β-cell antioxidant response. We used a combination of animal models of diabetes and ...

journal_title：Diabetes

authors： Marasco MR,Conteh AM,Reissaus CA,Cupit JE 5th,Appleman EM,Mirmira RG,Linnemann AK

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:The catabasis of inflammation is an active process directed by n-3 derived pro-resolving lipid mediators. We aimed to determine whether high-fat (HF) diet-induced n-3 deficiency compromises the resolution capacity of obese mice and thereby contributes to obesity-linked inflammation and insulin resistance. RE...

journal_title：Diabetes

authors： White PJ,Arita M,Taguchi R,Kang JX,Marette A

更新日期：2010-12-01 00:00:00

abstract：:Cultured bovine retinal capillary pericytes (BRP) were used to investigate the effect of an aldose reductase inhibitor, tolrestat, and an inhibitor of advanced glycation end products (AGE) formation, aminoguanidine, on glucose toxicity. Glucose at high concentration reduced the replicative activity of pericytes in a d...

journal_title：Diabetes

authors： Chibber R,Molinatti PA,Wong JS,Mirlees D,Kohner EM

更新日期：1994-06-01 00:00:00

abstract：:The effects of varying concentrations of ethanol (1, 10, and 30 mM) and its metabolites (1 mM acetate and 1 and 10 mM acetaldehyde) on insulin and glucagon secretion induced by glucose (11.1 mM) and arginine (20 mM) were studied in isolated perfused pancreas of Sprague-Dawley rats. Ethanol and its metabolites did not ...

journal_title：Diabetes

authors： Tiengo A,Valerio A,Molinari M,Meneghel A,Lapolla A

更新日期：1981-09-01 00:00:00

abstract：:The relationship between the levels of circulating thyroid hormones and the action of insulin on adipose tissue was investigated in 6 hypothyroid patients and 6 hyperthyroid patients, all untreated, and 8 healthy control subjects. All were matched for age, body weight, and fat cell size. Gluteal s.c. adipose tissue wa...

journal_title：Diabetes

authors： Arner P,Bolinder J,Wennlund A,Ostman J

更新日期：1984-04-01 00:00:00

abstract：:Hepatocyte nuclear factor-1alpha (HNF-1alpha) mutations are the most common cause of maturity-onset diabetes of the young. HNF-1alpha homozygous knockout mice exhibit a renal Fanconi syndrome with glucosuria and generalized aminoaciduria in addition to diabetes. We investigated glucosuria and aminoaciduria in patients...

journal_title：Diabetes

authors： Bingham C,Ellard S,Nicholls AJ,Pennock CA,Allen J,James AJ,Satchell SC,Salzmann MB,Hattersley AT

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:Pregnancy induces a state of immunological tolerance that aims at suppressing immune responses against the fetus and has been linked to temporal remission of preexisting autoimmune disorders. To understand the mechanisms of this reversible immune regulation, we investigated the role of a key pregnancy hormone...

journal_title：Diabetes

authors： Ueno A,Cho S,Cheng L,Wang J,Hou S,Nakano H,Santamaria P,Yang Y

更新日期：2007-06-01 00:00:00

abstract：:Sorbitol accumulation, myo-inositol depletion, and reduced Na+-K+-ATPase activity have been identified in experimental diabetes in several tissues in which diabetic complications occur. However, a reduction in renal Na+-K+-ATPase activity has not been universally reported, prompting us to examine the influence of diab...

journal_title：Diabetes

authors： Cohen MP,Klepser H

更新日期：1988-05-01 00:00:00

abstract：:Recent studies have emphasized the association of adipose oxidative stress (Fat reactive oxygen species [ROS]) with the pathogenesis of metabolic disorders in obesity. However, the causal roles of Fat ROS in metabolic disturbances in vivo remain unclear because no mouse model has been available in which oxidative stre...

journal_title：Diabetes

authors： Okuno Y,Fukuhara A,Hashimoto E,Kobayashi H,Kobayashi S,Otsuki M,Shimomura I

更新日期：2018-06-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) increases the content and mRNA level of insulin in a mouse beta-cell line, MIN6, and primary-cultured mouse islets. We examined the mechanism of PTHrP-induced insulin expression. The PTHrP effect was markedly augmented by SB203580, a mitogen-activated protein (MAP) kinase in...

journal_title：Diabetes

authors： Zhang B,Hosaka M,Sawada Y,Torii S,Mizutani S,Ogata M,Izumi T,Takeuchi T

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:The aim of the current study was to evaluate the long-term effects of leptin on glucose metabolism, diabetes complications, and life span in an insulin-dependent diabetes model, the Akita mouse. RESEARCH DESIGN AND METHODS:We cross-mated Akita mice with leptin-expressing transgenic (LepTg) mice to produce Ak...

journal_title：Diabetes

authors： Naito M,Fujikura J,Ebihara K,Miyanaga F,Yokoi H,Kusakabe T,Yamamoto Y,Son C,Mukoyama M,Hosoda K,Nakao K

更新日期：2011-09-01 00:00:00

abstract：:The risk of insulin-dependent diabetes mellitus (IDDM) was examined in siblings of an unselected population (n = 194) of newly diagnosed diabetic individuals less than 30 yr old. From 1 July 1984 to 30 June 1987, diabetic subjects (proband) identified within a geographically defined area of southern Wisconsin were stu...

journal_title：Diabetes

authors： Allen C,Palta M,D'Alessio DJ

更新日期：1991-07-01 00:00:00

abstract：OBJECTIVE:To ascertain the importance and mechanisms underlying the role of brain glucagon-like peptide (GLP)-1 in the control of metabolic and cardiovascular function. GLP-1 is a gut hormone secreted in response to oral glucose absorption that regulates glucose metabolism and cardiovascular function. GLP-1 is also pro...

journal_title：Diabetes

authors： Cabou C,Campistron G,Marsollier N,Leloup C,Cruciani-Guglielmacci C,Pénicaud L,Drucker DJ,Magnan C,Burcelin R

更新日期：2008-10-01 00:00:00

abstract：:Endothelial cells in culture retain many of the functional properties of the endothelium in vivo. At high cell density, they become contact-inhibited. Endothelial cells, like vascular smooth muscle cells and fibroblasts, express binding sites for low density lipoprotein when depleted of sterol. In contact-inhibited en...

journal_title：Diabetes

authors： Fielding CJ

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:A major feature of type 1 diabetes is the appearance of islet autoantibodies before diagnosis. However, although the genetics of type 1 diabetes is advanced, the genetics of islet autoantibodies needs further investigation. The primary susceptibility loci in type 1 diabetes, the HLA class I and II genes, are ...

journal_title：Diabetes

authors： Howson JM,Stevens H,Smyth DJ,Walker NM,Chandler KA,Bingley PJ,Todd JA

更新日期：2011-10-01 00:00:00

abstract：:Segmental pancreatic allografts with unligated ducts were transplanted intraperitoneally to five diabetic patients who had received renal allografts more than 2 yr earlier. One patient is alive with a functioning graft 10.5 mo later. Two patients rejected their grafts at approximately 2 and 3 mo but are alive 8--9 mo ...

journal_title：Diabetes

authors： Sutherland DE,Goetz FC,Najarian JS

更新日期：1980-01-01 00:00:00

abstract：:Three forms of disulfide-linked insulin receptor complexes are labeled by covalent cross-linking to receptor-bound 125I-insulin in native adipocyte or liver membranes. These receptors of Mr 350,000 Mr 320,000, and Mr 290,000 are composed of alpha (Mr 125,000), beta(Mr 90,000), and beta 1(Mr 49,000) subunits in stoichi...

journal_title：Diabetes

authors： Massaqué J,Czech MP

更新日期：1980-11-01 00:00:00

abstract：OBJECTIVE:ob/ob and db/db mice manifest myocardial hypertrophy, insulin resistance, altered substrate utilization, mitochondrial dysfunction, and lipid accumulation. This study was designed to determine the contribution of central and peripheral leptin signaling to myocardial metabolism and function in ob/ob and db/db ...

journal_title：Diabetes

authors： Sloan C,Tuinei J,Nemetz K,Frandsen J,Soto J,Wride N,Sempokuya T,Alegria L,Bugger H,Abel ED

更新日期：2011-05-01 00:00:00

abstract：:We examined the metabolic characteristics that attend the development of type 2 diabetes (T2DM) in 441 impaired glucose tolerance (IGT) subjects who participated in the ACT NOW Study and had complete end-of-study metabolic measurements. Subjects were randomized to receive pioglitazone (PGZ; 45 mg/day) or placebo and w...

journal_title：Diabetes

authors： Defronzo RA,Tripathy D,Schwenke DC,Banerji M,Bray GA,Buchanan TA,Clement SC,Gastaldelli A,Henry RR,Kitabchi AE,Mudaliar S,Ratner RE,Stentz FB,Musi N,Reaven PD,ACT NOW Study.

更新日期：2013-11-01 00:00:00

abstract：:We tested the hypothesis that green tea prevents diabetes-related tissue dysfunctions attributable to oxidation. Diabetic rats were treated daily with tap water, vitamins C and E, or fresh Japanese green tea extract. After 12 months, body weights were decreased, whereas glycated lysine in aorta, tendon, and plasma wer...

journal_title：Diabetes

authors： Mustata GT,Rosca M,Biemel KM,Reihl O,Smith MA,Viswanathan A,Strauch C,Du Y,Tang J,Kern TS,Lederer MO,Brownlee M,Weiss MF,Monnier VM

更新日期：2005-02-01 00:00:00

abstract：:Skeletal muscle insulin resistance in type 2 diabetes is associated with a shift from oxidative to glycolytic metabolism in myofibers. However, whether this metabolic switch is detrimental or adaptive for metabolic homeostasis has not been resolved. We recently demonstrated that the Baf60c/Deptor pathway promotes glyc...

journal_title：Diabetes

authors： Meng ZX,Wang L,Xiao Y,Lin JD

更新日期：2014-05-01 00:00:00

abstract：:Recent large-scale epidemiological studies demonstrate that blood concentrations of immunoreactive insulin predict the development of NIDDM and IDDM and are associated with the risk of several degenerative diseases, such as coronary and peripheral vessel atherosclerosis, hypertension, and dyslipidemia. The reliability...

journal_title：Diabetes

authors： Robbins DC,Andersen L,Bowsher R,Chance R,Dinesen B,Frank B,Gingerich R,Goldstein D,Widemeyer HM,Haffner S,Hales CN,Jarett L,Polonsky K,Porte D,Skyler J,Webb G,Gallagher K

更新日期：1996-02-01 00:00:00