Assessing the genetic diversity of the aldolase genes of Plasmodium falciparum and Plasmodium vivax and its potential effect on performance of aldolase-detecting rapid diagnostic tests.

Abstract:

:Malaria-specific rapid diagnostic tests (RDTs) targeting aldolase show highly variable sensitivities. We assessed diversity in Plasmodium falciparum and P. vivax aldolases by sequencing the coding genes from parasites of various origins. The results show that aldolases are highly conserved, indicating that antigenic diversity is not a cause of variable RDT sensitivity.

journal_name

J Clin Microbiol

authors

Lee N,Baker J,Bell D,McCarthy J,Cheng Q

doi

10.1128/JCM.01611-06

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

4547-9

issue

12

eissn

0095-1137

issn

1098-660X

pii

JCM.01611-06

journal_volume

44

pub_type

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