Effect of localized hyperthermia on TA3Ha tumor transplanted subcutaneously in the tails of mice.

abstract：:In the immediately preceding paper, we demonstrated that the microvasculature supplying peritoneal lining tissues of mice bearing either of two transplantable ascites carcinomas was hyperpermeable to circulating macromolecules. Solid tumors have been shown to exhibit similar levels of microvascular hyperpermeability, ...

journal_title：Cancer research

authors： Nagy JA,Meyers MS,Masse EM,Herzberg KT,Dvorak HF

更新日期：1995-01-15 00:00:00

abstract：:Genomic imprinting is an epigenetic modification of the gamete or zygote leading to parental origin-specific gene expression in somatic cells of the offspring. We have previously identified a cluster of imprinted genes on human chromosome 11p15.5, a region involved in Beckwith-Wiedemann syndrome, Wilms' tumor, and ova...

journal_title：Cancer research

authors： Lee MP,Feinberg AP

更新日期：1998-03-01 00:00:00

abstract：:Despite favorable responses to initial therapy, small-cell lung cancer (SCLC) relapse occurs within a year and exhibits resistance to multiple drugs. Because of limited accessibility of patient tissues for research purposes, SCLC patient-derived xenografts (PDX) have provided the best opportunity to address this limit...

journal_title：Cancer research

authors： Tripathi SC,Fahrmann JF,Celiktas M,Aguilar M,Marini KD,Jolly MK,Katayama H,Wang H,Murage EN,Dennison JB,Watkins DN,Levine H,Ostrin EJ,Taguchi A,Hanash SM

更新日期：2017-08-15 00:00:00

abstract：:The MAGE-1 gene codes for a tumor-specific antigen, MZ2-E, that elicited a cytotoxic T-lymphocyte response in the melanoma patient from whom it was derived. We have developed a simplified method, using polymerase chain reaction amplification of exon 3 followed by restriction enzyme pattern analysis, to distinguish exp...

journal_title：Cancer research

authors： Zakut R,Topalian SL,Kawakami Y,Mancini M,Eliyahu S,Rosenberg SA

更新日期：1993-01-01 00:00:00

abstract：:Aneuploidy is invariably associated with poor proliferation of primary cells, but the specific contributions of abnormal karyotypes to cancer, a disease characterized by aneuploidy and dysregulated proliferation, remain unclear. In this study, I demonstrate that the transcriptional alterations caused by aneuploidy in ...

journal_title：Cancer research

authors： Sheltzer JM

更新日期：2013-11-01 00:00:00

abstract：:Human breast cancers include cancer stem cell populations as well as nontumorigenic cancer cells. Breast cancer stem cells have self-renewal capability and are resistant to conventional chemotherapy. miRNAs regulate the expression of many target genes; therefore, dysregulation of miRNAs has been associated with the pa...

journal_title：Cancer research

authors： Park EY,Chang E,Lee EJ,Lee HW,Kang HG,Chun KH,Woo YM,Kong HK,Ko JY,Suzuki H,Song E,Park JH

更新日期：2014-12-15 00:00:00

abstract：:Impaired glucose metabolism and hyperinsulinemia have been hypothesized to increase breast cancer risk. However, findings from observational studies relating blood concentrations of hyperinsulinemia markers to breast cancer risk have been inconsistent. We prospectively evaluated whether hemoglobin A1c (HbA1c) concentr...

journal_title：Cancer research

authors： Lin J,Ridker PM,Rifai N,Lee IM,Manson JE,Buring JE,Zhang SM

更新日期：2006-03-01 00:00:00

abstract：:It has been shown that the systemic administration of lymphokine-activated killer (LAK) cells with recombinant interleukin 2 (RIL-2) is effective in reducing the number of established pulmonary and hepatic metastases in murine models. Similarly, this modality of therapy has been proven effective against certain select...

journal_title：Cancer research

authors： Lafreniere R,Borkenhagen K,Bryant LD,Huchcroft S

更新日期：1989-05-01 00:00:00

abstract：:The effects of the dopamine agonist bromocriptine and antagonist haloperidol on the incidence and histology of colon tumors induced by azoxymethane and on the labeling index of colon mucosa were investigated in Wistar rats. Rats received weekly s.c. injections of 7.4 mg/kg of body weight azoxymethane for 10 weeks and ...

journal_title：Cancer research

authors： Iishi H,Baba M,Tatsuta M,Okuda S,Taniguchi H

更新日期：1991-11-15 00:00:00

abstract：:Decyl and phenyl disulfide derivatives of 6-mercaptopurine and 6-thioguanine (6-TG) were examined for antineoplastic activity under aerobic and hypoxic conditions toward EMT6 cells in culture. Although these derivatives did not display selective toxicity toward the hypoxic cells, they were significantly more toxic tha...

journal_title：Cancer research

authors： Kirkpatrick DL

更新日期：1987-08-15 00:00:00

abstract：:Busulfan (1,4-butanediol dimethanesulfonate, BU) is relatively unique among other standard chemotherapy compounds in its ability to deplete noncycling primitive stem cells in the host and consequently to allow for high levels of long-term, donor-type engraftment after bone marrow transplantation (BMT). Such a property...

journal_title：Cancer research

authors： Westerhof GR,Ploemacher RE,Boudewijn A,Blokland I,Dillingh JH,McGown AT,Hadfield JA,Dawson MJ,Down JD

更新日期：2000-10-01 00:00:00

abstract：:BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is accumulating evidence that overexpression of BAG-1 may play an important role in breast cancer; however, the functional consequences of BAG-1 expression and its mechanism of action in breast cancer cells have not been stu...

journal_title：Cancer research

authors： Townsend PA,Cutress RI,Sharp A,Brimmell M,Packham G

更新日期：2003-07-15 00:00:00

abstract：:The ability to modulate DNA repair has been proposed as an effective method to overcome cytotoxic drug resistance in human tumors. However, no studies have shown that it is possible to achieve modulation of DNA repair in humans in vivo. This study analyzes modulation of O6-alkylguanine-DNA alkyltransferase, a DNA repa...

journal_title：Cancer research

authors： Gerson SL

更新日期：1989-06-01 00:00:00

abstract：:Human papillomaviruses (HPV), especially genotypes 16 and 18, are probable effectors of human urogenital malignancies. Although the male urethra is a proposed reservoir of HPV transmission, the association between HPV and squamous cell carcinoma (SCC) of the male urethra has not been studied. The highly sensitive tech...

journal_title：Cancer research

authors： Wiener JS,Liu ET,Walther PJ

更新日期：1992-09-15 00:00:00

abstract：:The influence of gangliosides on tumor growth and frequency of metastasis in vivo as well as on growth and motility of neoplastic cells in vitro was tested utilizing human and rodent cell populations. In mice receiving injections of a ganglioside mixture twice daily the tumor volume, the number of spontaneous metastas...

journal_title：Cancer research

authors： Alessandri G,Filippeschi S,Sinibaldi P,Mornet F,Passera P,Spreafico F,Cappa PM,Gullino PM

更新日期：1987-08-15 00:00:00

abstract：:The p53 tumor suppressor gene product is known to be active in mediating radiation-induced G1-S cell cycle arrest and apoptosis in a number of normal cell lines. These functions are compromised by inactivation of p53, which promotes tumor progression. Because the p53 gene appears to play an important role in the cellu...

journal_title：Cancer research

authors： Gallardo D,Drazan KE,McBride WH

更新日期：1996-11-01 00:00:00

abstract：:The LNCaP cell line was established from a metastatic lesion of human prostatic adenocarcinoma. The LNCaP cells grow readily in vitro (up to 8 x 10(5) cells/sq cm; doubling time, 60 hr), form clones in semisolid media, are highly resistant to human fibroblast interferon, and show an aneuploid (modal number, 76 to 91) ...

journal_title：Cancer research

authors： Horoszewicz JS,Leong SS,Kawinski E,Karr JP,Rosenthal H,Chu TM,Mirand EA,Murphy GP

更新日期：1983-04-01 00:00:00

abstract：:Microbial carboxyl and catechol siderophores have been shown to have natural iron-chelating abilities, suggesting that hyaluronic acid (HA) and the catechol compound, gallic acid (GA), may have iron-coordinating activities. Here, a photoresponsive self-gelling hydrogel that was both injectable and could be applied to ...

journal_title：Cancer research

authors： Ko S,Park JY,Oh YK

更新日期：2019-12-15 00:00:00

abstract：:The mechanisms by which a primary tumor affects a selected distant organ before tumor cell arrival remain to be elucidated. This report shows that Gr-1+CD11b+ cells are significantly increased in lungs of mice bearing mammary adenocarcinomas before tumor cell arrival. In the premetastatic lungs, these immature myeloid...

journal_title：Cancer research

authors： Yan HH,Pickup M,Pang Y,Gorska AE,Li Z,Chytil A,Geng Y,Gray JW,Moses HL,Yang L

更新日期：2010-08-01 00:00:00

abstract：:Splenocytes from mice bearing a cachexia-inducing tumor (MAC16) have been fused with mouse myeloma cells to produce hybridomas, which have been cloned to produce antibody reactive to a material which copurified with a lipid-mobilizing factor isolated from the same tumor. The monoclonal antibody has been used to invest...

journal_title：Cancer research

authors： Todorov PT,McDevitt TM,Cariuk P,Coles B,Deacon M,Tisdale MJ

更新日期：1996-03-15 00:00:00

abstract：:Four glutathione transferases (EC 2.5.1.18), glutathione transferases A, B, and C and a hitherto unknown form, termed X, were purified to apparent homogeneity from rat liver cytosol. They were investigated for their abilities to inactivate two mutagenic epoxides derived from the polycyclic aromatic hydrocarbon benz(a)...

journal_title：Cancer research

authors： Glatt H,Friedberg T,Grover PL,Sims P,Oesch F

更新日期：1983-12-01 00:00:00

abstract：:Well-coupled mitochondria of hematopoietic tumors were isolated from mouse erythroleukemia and rat chloroma tumors grown in male DBA/2J mice and Long-Evans rats, respectively. We used erythroleukemia and chloroma mitochondria to determine their ability to utilize glutamine as an energy source for adenosine triphosphat...

journal_title：Cancer research

authors： Abou-Khalil WH,Yunis AA,Abou-Khalil S

更新日期：1983-05-01 00:00:00

abstract：:The purpose of these studies was to select in vitro tumor cells that were resistant to macrophage-mediated lysis. Seven different heterogeneous murine neoplasms (four fibrosarcomas, a melanoma, a rhabdomyosarcoma, and an osteogenic sarcoma) and one cloned line of a fibrosarcoma were incubated in vitro with syngeneic t...

journal_title：Cancer research

authors： Fogler WE,Fidler IJ

更新日期：1985-01-01 00:00:00

abstract：:Human and murine cancers can express multiple independent antigens as targets for cytolytic T-cells (CTLs). The immune response against one such tumor was studied at the cellular and molecular level by analyzing the T-cell receptor beta chains of CTLs responding in vivo to a murine UV light-induced cancer. A 5-13-fold...

journal_title：Cancer research

authors： Seung S,Urban JL,Schreiber H

更新日期：1993-02-15 00:00:00

abstract：:Despite considerable efforts to improve early detection of ovarian cancer, the majority of women at time of diagnosis will have metastatic disease. Understanding and targeting the molecular underpinnings of metastasis continues to be the principal challenge in the clinical management of ovarian cancer. Whereas the mul...

journal_title：Cancer research

authors： Hickson JA,Huo D,Vander Griend DJ,Lin A,Rinker-Schaeffer CW,Yamada SD

更新日期：2006-02-15 00:00:00

abstract：:Promoter methylation of the mismatch repair gene plays a key role in sporadic microsatellite instability (MSI) colorectal cancers. However, promoter methylation often occurs in proximal colon cancers, and molecular phenotypes underlying MSI cancers in distal colon have not been fully clarified. Our goal was to clarify...

journal_title：Cancer research

authors： Watanabe T,Kobunai T,Toda E,Yamamoto Y,Kanazawa T,Kazama Y,Tanaka J,Tanaka T,Konishi T,Okayama Y,Sugimoto Y,Oka T,Sasaki S,Muto T,Nagawa H

更新日期：2006-10-15 00:00:00

abstract：:Angiostatin4.5 (AS4.5) is a naturally occurring human angiostatin isoform, consisting of plasminogen kringles 1-4 plus 85% of kringle 5 (amino acids Lys78 to Arg529). Prior studies indicate that plasminogen is converted to AS4.5 in a two-step reaction. First, plasminogen is activated to plasmin. Then plasmin undergoes...

journal_title：Cancer research

authors： Wang H,Schultz R,Hong J,Cundiff DL,Jiang K,Soff GA

更新日期：2004-01-01 00:00:00

abstract：:Chromosomal aberrations associated with lung cancer are frequently observed in the long arm of chromosome 6. A candidate susceptibility locus at 6q23-25 for lung cancer was recently identified; however, no tumor suppressor genes inactivated by mutation have been identified in this locus. Genetic, epigenetic, gene expr...

journal_title：Cancer research

authors： Tessema M,Willink R,Do K,Yu YY,Yu W,Machida EO,Brock M,Van Neste L,Stidley CA,Baylin SB,Belinsky SA

更新日期：2008-03-15 00:00:00

abstract：:beta 1-4 N-acetylglucosaminyltransferase (GnT-III) catalyzes the formation of bisecting N-acetylglucosamine (GlcNAc) in the biosynthesis of N-linked oligosaccharides. To examine the effect of bisecting GlcNAc on the natural killer (NK) cytotoxicity, the GnT-111 gene was introduced into NK-sensitive K562 cells that hav...

journal_title：Cancer research

authors： Yoshimura M,Ihara Y,Ohnishi A,Ijuhin N,Nishiura T,Kanakura Y,Matsuzawa Y,Taniguchi N

更新日期：1996-01-15 00:00:00

abstract：:The study of DNA tumor viruses has been invaluable in uncovering the cellular nodes and pathways that contribute to oncogenesis. Perhaps one of the best-studied oncoproteins encoded by a DNA tumor virus is adenovirus E1A, which modifies the function of key regulatory proteins such as retinoblastoma (Rb) and the chroma...

journal_title：Cancer research

authors： Chakraborty AA,Tansey WP

更新日期：2009-01-01 00:00:00