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Protective effects of erythropoietin in cardiac ischemia: from bench to bedside.

Abstract：

:Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates hematopoiesis in the bone marrow. However, recent studies have also shown important nonhematopoietic effects of EPO. A functional EPO receptor is found in the cardiovascular system, including endothelial cells and cardiomyocytes. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis. In the longer term, EPO may promote ischemia-induced neovascularization, either by stimulating endothelial cells in situ or by mobilizing endothelial progenitor cells from bone marrow. The effects of EPO in the ischemic heart support the concept of EPO as a pleiotropic, tissue-protective agent for other organs expressing the EPO receptor. We recently performed a first randomized clinical study showing the safety and feasibility of EPO administration in patients with acute myocardial infarction. Future clinical studies are warranted to translate the beneficial effects of EPO from basic experiments to cardiac patients.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Lipsic E,Schoemaker RG,van der Meer P,Voors AA,van Veldhuisen DJ,van Gilst WH

doi

10.1016/j.jacc.2006.08.031

subject

Has Abstract

pub_date

2006-12-05 00:00:00

pages

2161-7

issue

11

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(06)02333-3

journal_volume

48

pub_type

杂志文章,评审

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