[Multifocal ischaemic stroke and myocardial infarction in a woman with occult lung cancer complicated with chronic DIC and thrombotic endocarditis].

Abstract:

:Ischaemic stroke in thromboembolic mechanism may be a first sign of neoplastic disease, as in the presented case of a 56-year-old woman. Progressive trombocytopenia, anaemia with reticulocytosis and schistocytes in peripheral blood smear, elevated serum LDH activity as well as coexisting myocardial infarction initially suggested Moschcowitz syndrome. However, plasma exchange did not improve her neurological status and D-dimer values increase in subsequent evaluations indicated chronic DIC. At the same time, on transesophageal echocardiography, thrombotic endocarditis was diagnosed. Screening for cancer showed high CA 125 marker and chest computed tomography revealed lung tumor, not visible on earlier chest X-ray. In further treatment she underwent palliative radiotherapy and continued low molecular weight heparin. The neoplastic process had an unfavorable course and she died after four months. The authors point out that in case of multifocal ischaemic stroke and coexistent thrombocytopenia, neoplastic hypercoagulable state and thrombotic endocarditis should be considered.

journal_name

Neurol Neurochir Pol

authors

Elikowski W,Maka K,Ból K,Jedliński I,Kubaszewska M

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

530-5

issue

6

eissn

0028-3843

issn

1897-4260

pii

7280

journal_volume

40

pub_type

杂志文章
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  • [Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in adult patients with epilepsy resistant carbamazepine and valproate].

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    doi:

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  • [Motor variant of the unilateral neglect syndrome as a consequence of brain injury].

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  • [Morphological and functional studies of the lacerated sciatic nerve in rats after using various suture technics].

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  • [Periodic EEG discharges of stereotyped morphology].

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    doi:

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    doi:

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