Abstract:
UNLABELLED:Lamotrigine is a broad-spectrum antiepileptic drug which is thought to act in part via a use-dependent blockade of voltage-sensitive sodium channels to stabilise the neuronal membrane. This results in the inhibition of the excessive release of excitatory amino acids, such as glutamate, during epileptic activity. An open, multicentre, prospective trial of lamotrigine was carried out in adult patients with drug-resistant epilepsy on monotherapy with carbamazepine or valproate. The primary aim of the study was to assess add-on lamotrigine withdrawing to monotherapy. 28-week clinical trial was divided into 4 phases: (1) Dose escalation period (4 weeks), (2) Add-on period (8 weeks), (3) Standard AED withdrawal period (8 weeks), (4) Lamotrigine monotherapy (8 weeks). Thirty-three patients were previously treated with valproate, 44 with carbamazepine. Of 77 patients recruited into the study, 64 patients (83%) completed add-on therapy, 49 patients (64%) completed lamotrigine monotherapy. 44% of all patients during the add-on phase and 48% during lamotrigine monotherapy had a reduction in seizure frequency of at least 50% compared with pre-study period. 13% of all patients achieved seizure freedom during add-on therapy and 18% during monotherapy. Improvement of Visual Analogue Scale (VAS) scores was observed in 65% and 57% patients respectively. A significant proportion of patients could be successfully converted to lamotrigine monotherapy. Lamotrigine was also generally well tolerated. 23 patients (30%) had at least one adverse event (AE), but only 1/4 of all AEs might be reasonably regarded as an effect of the medication. 7 patients (9%) discontinued prematurely from the study due to adverse event. More AEs were observed in add-on therapy than in lamotrigine monotherapy. The safety profile was consistent with that seen during other clinical trials with lamotrigine. CONCLUSIONS:1. Lamotrigine is effective AED in add-on and monotherapy (responders rate--44% and 48% respectively). 2. In most cases conversion from add-on therapy to monotherapy can be done successfully. 3. Lamotrigine is a safe and well-tolerated drug.
journal_name
Neurol Neurochir Poljournal_title
Neurologia i neurochirurgia polskaauthors
Jóźwiak S,Niedzielska K,Mańko E,Terczyński Asubject
Has Abstractpub_date
2000-07-01 00:00:00pages
673-89issue
4eissn
0028-3843issn
1897-4260journal_volume
34pub_type
临床试验,杂志文章abstract::The authors describe a case of spinal intracanal cysticercosis. The cysts were situated intradurally, provoking radicular symptoms: pain, paresis. CT investigations showed herniation of discs L4/L5 and L5/S1 interpreted as the cause of the mentioned symptoms. Surgical treatment included discectomy L4/L5 and L5/S1. Rec...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::The purpose of the study was an assessment of the reinnervation of paralysed rat muscles after implantation of nerve into muscle venter (neurotization). The study was carried out in three groups of rats, with neurotization performed in two groups, the third group served as control. Reinnervation was assessed by means ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::We present a case of bilateral hematoma in cerebellar hemispheres in a 30-year-old man after surgical treatment of extensive left frontal glioma. 16 hours after surgery the patient lost consciousness. An immediate CT revealed hematoma in both cerebellar hemispheres. The hematoma was subsequently removed via bilateral ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::The aim of this study is to present a clinical role for 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in the differential diagnosis in patients with parkinsonian syndromes. We present a 51-year-old woman with parkinsonian syndrome and syncope occurrence. She reproduced spontaneous syncope in the tilt tes...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
abstract::A case of conus medullaris tumour (ependymoma) is reported in which the presenting symptom was subarachnoid haemorrhage, which has left bladder dysfunction. 70-year-old patient was admitted to the Department of Neurology due to symptoms of conus medullaris lesion with retention of urine and diminished pain sensitivity...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::Epidemiological investigations were carried out in an industrial plant in a population of about 16 000 people. The overall morbidity was 1 241.8 cases of nervous system diseases per 100 000 of population and the annual prevalence of neurological diseases was 473.7 per 100 000. The most frequent disease was sciatic pai...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1976-09-01 00:00:00
abstract::A 20-year-old female, university student presented with severe, throbbing, unilateral headache, nausea and vomiting that started 2 days ago. The pain was aggravated with physical activity and she had photophobia. She had been taking contraceptive pills due to polycystic ovary for 3 months. Cranial computed tomography ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2015.01.005
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Activation of platelets and endothelial cells plays an important role in the pathogenesis of atherosclerosis and thrombotic disorders. The aim of our study was to assess the relationship between the metabolic disorders and markers of platelet activity and vascular injury in patient with acute ischemic stroke...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2018.08.004
更新日期:2018-01-01 00:00:00
abstract::In the Department of Neurosurgery of the Medical University of Warsaw 11 patients with primary central nervous system lymphomas were diagnosed and treated between 1990 and 1999. The patients comprised of 6 females and 5 males, aged 23 to 86 years, with most patients presenting in the sixth decade. The time from first ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of our study was to evaluate brain perfusion in patients with vertigo using the SPECT technique. METHODS:The study involved a group of 32 patients and was performed in the Neurological Department of the Medical University in Bialystok. Patients with vertigo of peripheral origin like midd...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract::One of the most common children's ailments are headaches--based on literature--about 75% of the population under the age of 15 suffers from them. The aim of the study was to evaluate the influence of headache on the quality of life in children and adolescents. The study group was made up of 86 persons between the age ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::The authors describe the epidemiological situation with regard to late syphilis in the period of 25 years with particular reference to the last decade (1965--1974). The activities of consultation services for late syphilis and their role in prevention of late organ involvement are discussed. ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::A patient is reported with a history of subarachnoid haemorrhage and coexistent intracerebral and subdural haematomas. The source of haemorrhage were two pial arteriovenous fistulae supplied by the frontopolar artery. They coexisted with a meningeal arteriovenous fistula supplied by the anterior meningeal branch of th...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1988-11-01 00:00:00
abstract::A 23 year old woman with dissecting aneurysm of the left posterior inferior cerebellar artery located distal to the branch feeding medulla oblongata is described. Trapping of the aneurysm with the aid of 2 clips was without any influence on neurological state of the patient and prevented recurrent hemorrhage. ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract::A group of 69 patients aged 60-80 years with brain tumours were analysed, estimating the surgical risk at the time of qualification for operations. Surgical treatment was given to 36 patients limiting it to lobectomy of the part of the brain containing the greater part of the tumour. The peri-operational mortality was...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::The authors report the results of surgical treatment of 11 patients with carpal tunnel syndrome. The group comprised 10 women and 1 man. In 4 cases bilateral symptoms were present. The duration of the disease was from 6 months to 10 years (mean 4.2 years). In all patients operation was followed by complete disappearan...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::In 18 men with Horton's headaches the levels of the following hormones were determined in the serum: TSH, T3 and T4. The determinations were performed during disease relapse and before starting treatment. The control group included 18 blood donors. In the control group the mean TSH level was 3.97 +/- 0.88 microunits/m...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1981-09-01 00:00:00
abstract::The preliminary studies on cerebral blood flow changes during neuropsychologic tests were carried out using transcranial Doppler sonography (TCD). The procedure with the standardized cerebral activation in order to obtain the control brain activity level was elaborated and tested. Blood flow velocity changes were meas...
journal_title:Neurologia i neurochirurgia polska
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1994-11-01 00:00:00
abstract:INTRODUCTION:Non-invasive bladder cancer is effectively treated with intravesical BCG therapy. The administration of the BCG vaccine is to destroy the neoplastic lesion or prevent further recurrences. The activity of the vaccine involves boosting the immune system through the stimulation of the inflammation in the blad...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2015.12.003
更新日期:2016-01-01 00:00:00
abstract::On the basis of experimental investigations the authors describe the causes of certain complications after extracorporeal circulation. The experiments were carried out in 11 sheep. The duration of extracorporeal circulation was from 1 to 2 hours. It was found that the intracranial pressure, which is an indicator of in...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We present detailed results of using Neuroform stent-assisted coil embolization to treat complex cerebral aneurysms over a three-year period. MATERIAL AND METHODS:Only patients who underwent Neuroform stent-assisted coil embolization were included in this study. We assessed patients' history, an...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/s0028-3843(14)60296-6
更新日期:2010-07-01 00:00:00
abstract::Marchiafava-Bignami disease (MBD) is a rare fatal neurological disorder characterized by demyelination, primary degeneration, and necrosis of the corpus callosum. Although MBD is mostly associated with chronic alcohol consumption and malnutrition, it has been reported in non-alcoholic patients. Serotonin syndrome is a...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2017.10.011
更新日期:2018-03-01 00:00:00
abstract::On the basis of a study of 218 control subjects in 10-year age groups the authors determined the mean levels and critical values of certain serum lipid components (cholesterol, triglycerides, beta-lipoproteins, esterified fatty acids and total lipids). Forty-two subjects were isolated (11.2%) with hyperlipoproteinaemi...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1981-07-01 00:00:00
abstract::In a period of 15 months in a material of 235 surgically verified brain tumours in 8 cases (3.4%) hemorrhages into the tumour mass were found. In 3 of these cases the tumours were anaplastic astrocytomas, the remaining tumours were: oligodendroglioma, meningioma, pituitary adenoma and metastases of renal carcinoma and...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1983-07-01 00:00:00
abstract:OBJECTIVE:Vertebral artery medulla compression syndrome (VAMCS) is a very rare condition manifesting as different neurological focal deficits. The case of a 36-year-old male with symptomatic brainstem compression by vertebral artery (VA) treated by means of microvascular decompression (MVD) and a review of the literatu...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2018.03.005
更新日期:2018-08-01 00:00:00
abstract::The presented case concerns a patient with neuralgia of the common peroneal nerve and progressive neurological deficit caused by interfascicular growth of schwannoma. The ultrasound diagnostics identified the lesion as a popliteal cyst. Magnetic resonance imaging revealed features of atypical cyst location. Due to the...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.5114/ninp.2012.30273
更新日期:2012-07-01 00:00:00
abstract::An original method is presented used for production of experimental aneurysms in rats. The method may be useful in training for microneurosurgical treatment of aneurysms. ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::We describe the effects of unilateral right-sided nucleus accumbens (NA) stimulation in a patient with intractable Gilles de la Tourette syndrome (GTS) with associated compulsions and self-injurious behaviour. Pharmacological and behavioural therapies had completely failed to control the patient's tics and compulsions...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract::The authors discuss a case of a 46 year-old man with bilateral internal carotid artery and right vertebral artery occlusion in unexpectedly good clinical state. The clinical diagnosis is documented by angiographic and doppler findings and brain CT scan. ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::Arteriosclerosis is a multisystem disease and the association between carotid and coronary artery disease is well known. The incidence of significant carotid stenosis in patients undergoing coronary artery bypass graft (CABG) varies from 3% to 22%. Haemodynamically significant carotid disease is present in 2.8% to 7.8...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章,评审
doi:
更新日期:2009-05-01 00:00:00