Abstract：
:Ghrelin is a gut peptide which participates in growth regulation through its somatotropic, lipogenic and orexigenic effects. Synergism of ghrelin and growth hormone-releasing hormone (GHRH) on growth hormone (GH) secretion has been reported in humans and rats, but not in domestic animals in vivo. In this study, effects of a combination of ghrelin and GHRH on plasma GH and other metabolic parameters, and changes in plasma active and total ghrelin levels were studied in Holstein bull calves before and after weaning. Six calves were intravenously injected with vehicle (0.1% BSA-saline), ghrelin (1 microg/kg BW), GHRH (0.25 microg/kg BW) or a combination of ghrelin plus GHRH at the age of 5 weeks and 10 weeks (weaning at 6 weeks of age). Ghrelin stimulated GH release with similar potency as GHRH and their combined administration synergistically stimulated GH release in preweaning calves. After weaning, GH responses to ghrelin and GHRH became greater compared with the values of preweaning calves, but a synergistic effect of ghrelin and GHRH was not observed. The GH areas under the concentration curves for 2h post-injection were greater in weaned than in preweaning calves (P<0.05) if ghrelin or GHRH were injected alone, but were similar if ghrelin and GHRH were injected together. Basal plasma active and total ghrelin levels did not change around weaning, but transiently increased after ghrelin injection. Basal plasma insulin, glucose and non-esterified fatty acid levels were reduced after weaning, but no changes by treatments were observed. In conclusion, ghrelin and GHRH synergistically stimulated GH release in preweaning calves, but this effect was lost after weaning.
journal_name
Domest Anim Endocrinoljournal_title
Domestic animal endocrinologyauthors
ThidarMyint H,Yoshida H,Ito T,He M,Inoue H,Kuwayama Hdoi
10.1016/j.domaniend.2006.12.001subject
Has Abstractpub_date
2008-01-01 00:00:00pages
118-23issue
1eissn
0739-7240issn
1879-0054pii
S0739-7240(06)00169-Xjournal_volume
34pub_type
杂志文章abstract：:Satellite cells are the postnatal myogenic cells, as they provide myonuclei to support skeletal muscle hypertrophy and are principal cells responsible for myofiber repair and regeneration. Even though research with satellite cells from meat animals is new, considerable data exist to suggest that these cells are regula...
journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
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更新日期：1996-03-01 00:00:00
abstract：:Environment enrichment is a rising topic for animal welfare but measures to identify effective enrichment interventions are lacking. In humans and rodent species, environmental enrichment increases brain-derived neurotrophic factor (BDNF), the most abundant neurotrophin in the brain. Higher BDNF concentration is ultim...
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journal_title：Domestic animal endocrinology
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/j.domaniend.2006.07.003
更新日期：2007-11-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：1999-07-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/s0739-7240(99)00017-x
更新日期：1999-05-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/0739-7240(96)00050-1
更新日期：1996-07-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.domaniend.2012.03.005
更新日期：2012-08-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/0739-7240(90)90035-x
更新日期：1990-07-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/j.domaniend.2005.02.017
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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journal_title：Domestic animal endocrinology
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doi：10.1016/j.domaniend.2008.07.004
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：1997-03-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章,随机对照试验
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更新日期：2016-10-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/j.domaniend.2013.01.005
更新日期：2013-05-01 00:00:00
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journal_title：Domestic animal endocrinology
pub_type： 杂志文章
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更新日期：2000-10-01 00:00:00
abstract：:Receptors for LH (LHR) and FSH (FSHR) are expressed in the canine lower urinary tract (LUT). As gonadectomy results in an increase in plasma LH and FSH, the objective of this study was to determine whether there are any differences in the expression of LHR and FSHR in the LUT between intact and gonadectomised dogs. Fo...
journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/j.domaniend.2007.09.005
更新日期：2008-05-01 00:00:00
abstract：:Mature Hereford cows (n = 28) were used to determine the effect of percentage body fat on secretion of LH and content of GnRH in the infundibular stalk-median eminence (ISME). Cows were fed to maintain, lose, or gain weight to achieve body condition scores (BCS; 1 = emaciated; 9 = obese) of 3 to 7. Then cows were fed ...
journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/0739-7240(92)90010-u
更新日期：1992-01-01 00:00:00
abstract：:This is a test-report of ghrelin levels in plasma and proventriculus, the glandular portion of the avian stomach, by using a specific radioimmunoassay for acylated ghrelin, as well as the expression of the ghrelin gene in the proventriculus after a 12-h fasting period followed by a 6-h feeding period with 6-day-old la...
journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/j.domaniend.2006.03.006
更新日期：2007-05-01 00:00:00
abstract：:The effects of somatostatin immunoneutralization on growth rate, growth hormone (GH) secretion and circulating insulin-like growth factor I (IGF-I) concentrations were investigated in chickens through the use of passive and active immunization techniques. Intravenous bolus injection of goat-antisomatostatin stimulated...
journal_title：Domestic animal endocrinology
pub_type： 杂志文章
doi：10.1016/0739-7240(87)90015-4
更新日期：1987-07-01 00:00:00
