Second annual analysis of the collaborative islet transplant registry.


:In September 2001, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) founded the Collaborative Islet Transplant Registry (CITR). Each year, CITR produces a complete set of analyses available to the public. In its second year, CITR represents the efforts of 19 North American islet transplant programs reporting information on 138 islet transplant recipients (1999-2004), 256 processed pancreata that led to infusion, and 266 infusion procedures. This analysis focuses on recipients of islet-alone procedures. Median age of the recipient is 41.6 years (range, 23.1-64.4 years), duration of diabetes is 29 years (range, 4-50 years), and over 66% are female. Median weight of the recipient is 65 kg (range, 47-97 kg) and median body mass index (BMI) is 23.1 kg/m(2) (range, 18.8-31.6). Examining outcomes at 6 months following the recipient's last infusion, 67.0% are insulin independent, and at 12 months this percentage decreases to 58.0%. There is a striking decrease in the occurrence of severe hypoglycemic events subsequent to the first infusion. Over 82% of all recipients experience one or more severe hypoglycemic events in the year prior to their first infusion. However, only two recipients (2%) experience one or more severe hypoglycemic events between 30 days and 12 months postinfusion, but both of these recipients were on insulin replacement therapy and one had experienced a complete islet graft failure. The information provided in this analysis and subsequent analyses of CITR provides current and comprehensive information on outcome measures in islet transplantation.


Transplant Proc


Close N,Alejandro R,Hering B,Appel M,CITR Investigators.




Has Abstract


2007-01-01 00:00:00














  • Factors influencing the vaccinia-specific cytotoxic response of thymocytes from normal and chimeric mice.

    abstract::Following adoptive transfer into irradiated recipients, thymocytes can be induced to respond strongly to vaccinia virus. High levels of cytotoxic T-lymphocyte (CTL) activity may be generated from thymus, but not from spleen, of 3-day-old mice. The capacity of thymocytes to differentiate into effector CTL tends to be l...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Doherty PC,Schwartz DH,Bennink JR,Korngold R

    更新日期:1981-12-01 00:00:00

  • Selection Criteria for Kidney Laterality in Retroperitoneoscopic Living Donor Nephrectomy and the Usefulness of Pretransplant Intervention.

    abstract:OBJECTIVES:To evaluate the selection criteria for kidney laterality and the usefulness of pretransplant intervention in living donor nephrectomy. METHODS:We compared conventional and revised criteria. The conventional criteria were that left kidneys were chosen in preference and provided the kidney with the fewest str...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Nanmoku K,Kurosawa A,Kubo T,Shinzato T,Shimizu T,Kimura T,Yagisawa T

    更新日期:2017-06-01 00:00:00

  • Pregnancy and renal transplantation.

    abstract::Ovarian dysfunction, anovulatory vaginal bleeding, amenorrhea, high prolactin levels, and loss of libido are the causes of infertility in women with chronic renal failure. After renal transplantation, endocrine function generally improves after recovery of renal function. In this study we retrospectively evaluated the...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Başaran O,Emiroğlu R,Seçme S,Moray G,Haberal M

    更新日期:2004-01-01 00:00:00

  • Therapeutic drug monitoring of cyclosporine.

    abstract::Therapeutic drug monitoring of cyclosporine has been established as part of the routine clinical treatment for patients after organ transplantation. The inability to define optimal dose (maximize efficacy/minimize toxicity) has been a problem related to drug monitoring of cyclosporine. The original cyclosporine formul...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Midtvedt K

    更新日期:2004-03-01 00:00:00

  • Effect of methylene blue on the hemodynamic instability resulting from liver ischemia and reperfusion in rabbits.

    abstract::The experimental investigation was performed to study the effects of methylene blue (MB) on hemodynamic, biochemical, and tissue changes among rabbits undergoing liver ischemia and reperfusion (IR). Twenty-four rabbits were randomized into 5 groups: 1, SHAM, control; 2, MB infusion bolus (3 mg/kg); 3, IR, hepatic isch...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Rosique RG,Rosique MJ,Rosique IA,Tirapelli LF,Castro e Silva O Jr,dos Santos JS,Evora PR

    更新日期:2011-12-01 00:00:00

  • Information channels and the dynamics of uptake of living kidney donors: a retrospective study in a reference area.

    abstract:INTRODUCTION:Activity in renal transplantation at our center continues to grow due to the gradual increase in living donor kidney transplantations (LDKT). Our objective was to describe the generation process of living donation in our area of influence including two provinces and 18 chronic kidney disease (CKD) treatmen...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Vidal Blandino M,Gentil Govantes MA,Cabello Chaves V,Pereira Palomo P,Bernal Blanco G,Gonzalez Roncero FM,Fijo Viota J,Medina López R

    更新日期:2011-07-01 00:00:00

  • Prognostic impact of model for end-stage liver disease score in patients undergoing liver transplantation with suboptimal livers.

    abstract:BACKGROUND/AIMS:The aim of this retrospective study is to analyze the prognostic impact of Model for End-Stage Liver Disease (MELD) score in patients undergoing liver transplantation (OLT) with suboptimal livers. METHODS:Between January 2002 and January 2006, 160 adult patients with liver cirrhosis received a whole li...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Vitale A,D'Amico F,Brolese A,Zanus G,Boccagni P,Neri D,Gringeri E,Valmasoni M,Ciarleglio FA,Carraro A,Pauletto A,Bonsignore P,Bassi D,Polacco M,D'Amico DF,Cillo U

    更新日期:2007-07-01 00:00:00

  • Molecular Adsorbent Recirculating System Treatment Can Reduce Blood Levels of N-Acetylcysteine in Patients With Acetaminophen Overdose: Case Reports.

    abstract:BACKGROUND:Acetaminophen poisoning continues to be a major cause of liver failure that can lead to liver transplantation. N-acetylcysteine (NAC) is the cornerstone of treatment. Some authors use a Molecular Adsorbent Recirculating System (MARS) system in acetaminophen poisoning. It is reported that the MARS system elim...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lopez-Lopez V,Ros J,Ferreras D,Sanmartin J,Martinez M,Pons Miñano JA,Sanchez-Bueno F,Robles-Campos R,Ramirez-Romero P,Parrilla-Paricio P

    更新日期:2018-03-01 00:00:00

  • Identifying Predictors of Outcomes in Combined Heart and Liver Transplantation.

    abstract:BACKGROUND:Combined heart and liver transplant (CHLT) is a complex procedure that is being increasingly performed. Because of the relative rarity of this procedure, graft and patient outcomes are still being assessed and risk factors for graft and patient survival are unknown. MATERIALS AND METHODS:This is a retrospec...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lee S,Matsuoka L,Cao S,Groshen S,Alexopoulos SP

    更新日期:2019-01-01 00:00:00

  • Long-term outcomes of orthotopic heart transplantation for hypertrophic cardiomyopathy.

    abstract:BACKGROUND:Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease characterized by asymmetric or symmetric ventricular hypertrophy in the absence of an obvious clinical cause. Orthotopic heart transplantation (OHT) has been performed in patients who have refractory symptoms despite medical therapy and surg...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lee MS,Zimmer R,Kobashigawa J

    更新日期:2014-06-01 00:00:00

  • Severe rhabdomyolysis and acute renal failure in a kidney transplant patient treated with tacrolimus and chimaeric CD25 monoclonal antibody.

    abstract::Recently observations of rhabdomyolysis in patients treated with tacrolimus have been reported. The authors present a kidney transplant patient who had an epileptic seizures, severe rhabdomyolysis, and acute renal failure. The patient was initially immunosuppressed with tacrolimus and chimeric CD25 monoclonal antibody...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Fontana I,Ginevri F,Basile G,Beatini M,Bertocchi M,Bonifazio L,Saltalamacchia L,Ghinolfi D,Santori G,Valente R,Perfumo F,Valente U

    更新日期:2004-04-01 00:00:00

  • Posttransplant diabetes mellitus: incidence and risk factors.

    abstract:UNLABELLED:Posttransplant diabetes mellitus (PTDM) is common post transplantation and is associated with tacrolimus (TAC) and steroid therapy. The aim of the present study was to analyze the incidences of PTDM and associated risk factors. METHODS:We selected renal transplant recipients treated with TAC, mycophenolate ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mazali FC,Lalli CA,Alves-Filho G,Mazzali M

    更新日期:2008-04-01 00:00:00

  • Histological criteria for the identification of acute cellular rejection in human small bowel allografts: results of the pathology workshop at the VIII International Small Bowel Transplant Symposium.

    abstract::Acute cellular rejection remains a serious and frequent complication during the posttransplant course of small bowel allograft recipients. Currently, small bowel biopsies are the optimal method to identify this form of rejection. The morphological criteria for this diagnosis have been known for some time; however, no ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ruiz P,Bagni A,Brown R,Cortina G,Harpaz N,Magid MS,Reyes J

    更新日期:2004-03-01 00:00:00

  • Initial experience with sirolimus and mycophenolate mofetil for renal rescue from cyclosporine nephrotoxicity after heart transplantation.

    abstract::Calcineurin inhibitors (CNIs) have become the cornerstone of immunosuppressive regimens following heart transplantation, but their use is associated with nephrotoxicity. We evaluated a CNI elimination protocol in 14 patients with renal impairment at 48.3 +/- 36.0 months after heart transplantation. The mean serum crea...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lyster H,Panicker G,Leaver N,Banner NR

    更新日期:2004-12-01 00:00:00

  • Liver transplant combined with heart transplant in severe heterozygous hypercholesterolemia: report of the first case and review of the literature.

    abstract::Familial hypercholesterolemia (FH) is a dominant inherited disease of low-density lipoprotein (LDL) metabolism caused by mutations of LDL receptors mainly located in the liver. This metabolic disorder is responsible for severe cardiovascular disease, from coronary lesions to chronic heart failure (CHF). Liver transpla...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Alkofer BJ,Chiche L,Khayat A,Deshayes JP,Lepage A,Saloux E,Reznik Y

    更新日期:2005-06-01 00:00:00

  • The presence of donor-specific antibodies in renal transplantation.

    abstract::Determining the presence of anti-HLA antibodies before transplantation is an important factor to prevent loss of function among renal transplantations. In addition, recent studies have shown that not only the pretransplantation existence of anti-HLA antibody but also posttransplantation donor-specific antibodies (DSA)...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Tozkir H,Sağiroğlu T,Kiliçarslan-Ayna T,Tan S,Çopuroğlu E,Sağiroğlu G,Sari G,Gürkan H,Sezer A

    更新日期:2012-07-01 00:00:00

  • The effect of HBsAg-positivity of kidney donors on long-term patient and graft outcome.

    abstract::The number of patients on the kidney waiting list is increasing, creating a shortage of donor organs. To solve this problem, there is an interest in transplanting organs formerly considered marginal or undesirable. We performed seven (four living related, three cadaveric) kidney transplants from hepatitis B surface an...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Berber I,Aydin C,Yigit B,Turkmen F,Titiz IM,Altaca G

    更新日期:2005-12-01 00:00:00

  • Incidence, management, and results of vascular complications after liver transplantation.

    abstract:INTRODUCTION:Vascular complications show an 8%-15% incidence after liver transplantation and represent an important cause of mortality. An aggressive policy is necessary for an early diagnosis and treatment. PATIENTS AND METHODS:From 2001 to 2009, we performed 240 liver transplantations in 232 patients. We employed Do...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Pérez-Saborido B,Pacheco-Sánchez D,Barrera-Rebollo A,Asensio-Díaz E,Pinto-Fuentes P,Sarmentero-Prieto JC,Rodríguez-Vielba P,Martínez-Díaz R,Gonzalo-Martín M,Rodríguez M,Calero-Aguilar H,Pintado-Garrido R,García-Pajares F,Anta-R

    更新日期:2011-04-01 00:00:00

  • Nitric oxide and thromboxane A2 modulate pulmonary pressure after ischemia and intestinal reperfusion.

    abstract:INTRODUCTION:Nitric oxide (NO) and thromboxane A(2) (TxA(2)) are paracrine substances that likely contribute to IR-induced lung injury. This study examined the hypothesis that pulmonary vasoconstriction during ischemia is induced by NO synthesis and ischemia/reperfusion (IR)-induced TxA(2). METHODS:Wistar rats underwe...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Słupski M,Szadujkis-Szadurska K,Szadujkis-Szadurski R,Szadujkis-Szadurski L,Włodarczyk Z,Andruszkiewicz J,Sinjab AT

    更新日期:2006-01-01 00:00:00

  • Deceleration of Liver Regeneration by Knockdown of Heme Oxygenase-1 is Associated With Impairment of Liver Injury Recovery After Reduced-Size Liver Transplantation in Rats.

    abstract:AIM:It has been reported that heme oxygenase-1 (HO-1) is upregulated during hepatocyte proliferation. Herein, we used a half-size liver transplantation (HSLT) model to study the impact of HO-1 on liver grafts proliferation. To the best of our knowledge, this is the first time that HO-1 has been characterized as a regul...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Cheng B,Xie H,Jia J,Wu M,Guo J,Zhang Y,Liu Y,Zhou J,He N

    更新日期:2020-04-01 00:00:00

  • Prognosis after liver transplantation predicted by preoperative MELD score.

    abstract::The model for end-stage liver disease (MELD) has been an excellent predictor of 3-month mortality among cirrhotic patients awaiting orthotopic liver transplantation (OLT). The aim of this study was to evaluate whether the preoperative MELD score predicts short-term prognosis after OLT. We enrolled 98 adult liver trans...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kim DJ,Lee SK,Jo JW,Kim SJ,Kwon CH,Park JW,Han YS,Park JB

    更新日期:2006-09-01 00:00:00

  • Immunomonitoring of renal transplant recipients in the early posttransplant period by sequential analysis of chemokine and chemokine receptor gene expression in peripheral blood mononuclear cells.

    abstract:INTRODUCTION:We sought to determine whether sequential changes in chemokine ligand/receptor gene expression in the early posttransplant period of human renal allografts can be detected in peripheral blood mononuclear cells (PBMCs) and whether any such changes are predictive of clinical events. METHODS:Blood samples fr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Dalton RS,Webber JN,Pead P,Gibbs PJ,Sadek SA,Howell WM

    更新日期:2005-03-01 00:00:00

  • Urachal adenocarcinoma following kidney transplantation: the first case report.

    abstract::A 53-year-old man who underwent successful kidney transplantation for stage 5 chronic kidney disease presented to our clinic with intermittent painless gross hematuria. Urachal adenocarcinoma, stage III A by Sheldon system, was diagnosed after serial histopathologic and radiological studies. The patient was treated wi...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Tai HC,Chen YS,Wang SM,Chueh SC,Lai MK,Yu HJ

    更新日期:2009-06-01 00:00:00

  • Low graft function and ongoing hyperparathyroidism are closely related to post-transplantation osteoporosis.

    abstract:INTRODUCTION:Renal transplantation (RT) is the gold standard therapy for chronic renal failure. Immunosuppressive drug choice, malnutrition, adynamic bone disease and hyperparathyroidism are important factors impacting the development of posttransplant osteoporosis. Body composition analysis with bioimpedance devices (...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Tutal E,Uyar ME,Colak T,Bal Z,Demirci BG,Bozkurt T,Sezer S,Acar FN

    更新日期:2013-05-01 00:00:00

  • Organ donation: a portrait of family refusal in Québec.

    abstract::Many studies from around the world have reported different reasons why families refuse organ donation. In Quebec, however, there are no known data on the subject. To enable us to better communicate with families, a research project was conducted from January to December 2007 in hospital centers with personnel who spec...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Baran D,Langevin S,Lebeau C

    更新日期:2009-10-01 00:00:00

  • Use of high-dose human immune globulin in highly sensitized patients on the kidney transplant waiting list: one center's experience.

    abstract:INTRODUCTION:Transplant rates are low among highly sensitized patients with preformed anti-HLA antibodies, because of the additional immunologic barrier, the increased risk of rejection, and the greater chance of early graft loss. Intravenous infusion of pooled human immune globulin (IVIG) is immunomodulatory, neutrali...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Gozdowska J,Urbanowicz A,Perkowska-Ptasinska A,Michalska K,Chmura A,Szmidt J,Durlik M

    更新日期:2009-10-01 00:00:00

  • Association between hepatitis B and hepatocellular carcinoma recurrence in patients undergoing liver transplantation.

    abstract:BACKGROUND/AIMS:Hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) recurrences affect both patient and graft survivals post-orthotopic liver transplantation (OLT) in HBV patients with HCC. We analyzed the relationship between HBV and HCC recurrence in a large cohort of HBV-OLT patients with versus without HCC. ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kiyici M,Yilmaz M,Akyildiz M,Arikan C,Aydin U,Sigirli D,Nart D,Yilmaz F,Ozacar T,Karasu Z,Kilic M

    更新日期:2008-06-01 00:00:00

  • Organ donation: acceptance and refusal among users of the public health system from Brazil.

    abstract::The present study sought to identify the perception of a given group of users of the Brazilian Public Health System (Sistema Unico de Saúde) regarding organ donation and to implement an educational policy. Structured interviews were conducted with the aim of describing the profile of donor and nondonor subjects, the i...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sasso-Mendes KD,Curvo PA,Silveira RC,Galvão CM

    更新日期:2008-04-01 00:00:00

  • Study of the evolution of the clinical profile of heart donors.

    abstract:UNLABELLED:Certain characteristics of the donor have implications for the early and late survival of transplants. The trends show a progressive worsening in the clinical profile of heart donors. Our objective was to analyze changes in the clinical characteristics of donors. MATERIALS AND METHODS:This retrospective stu...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Almenar-Pertejo M,Almenar L,Martínez-Dolz L,Campos J,Galán J,Gironés P,Salvador A

    更新日期:2006-10-01 00:00:00

  • Combination therapy with anti-ICOS and cyclosporine enhances cardiac but not islet allograft survival.

    abstract::The blockade of costimulatory signals is a powerful strategy to prevent allograft rejection and facilitate transplantation tolerance. In recent years, a series of novel costimulatory molecules have been identified, including an inducible costimulatory molecule (ICOS). To date, little has been uncovered regarding the t...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Nanji SA,Hancock WW,Anderson CC,Zhu LF,Kneteman NM,Shapiro AM

    更新日期:2003-11-01 00:00:00