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Second annual analysis of the collaborative islet transplant registry.

Abstract：

:In September 2001, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) founded the Collaborative Islet Transplant Registry (CITR). Each year, CITR produces a complete set of analyses available to the public. In its second year, CITR represents the efforts of 19 North American islet transplant programs reporting information on 138 islet transplant recipients (1999-2004), 256 processed pancreata that led to infusion, and 266 infusion procedures. This analysis focuses on recipients of islet-alone procedures. Median age of the recipient is 41.6 years (range, 23.1-64.4 years), duration of diabetes is 29 years (range, 4-50 years), and over 66% are female. Median weight of the recipient is 65 kg (range, 47-97 kg) and median body mass index (BMI) is 23.1 kg/m(2) (range, 18.8-31.6). Examining outcomes at 6 months following the recipient's last infusion, 67.0% are insulin independent, and at 12 months this percentage decreases to 58.0%. There is a striking decrease in the occurrence of severe hypoglycemic events subsequent to the first infusion. Over 82% of all recipients experience one or more severe hypoglycemic events in the year prior to their first infusion. However, only two recipients (2%) experience one or more severe hypoglycemic events between 30 days and 12 months postinfusion, but both of these recipients were on insulin replacement therapy and one had experienced a complete islet graft failure. The information provided in this analysis and subsequent analyses of CITR provides current and comprehensive information on outcome measures in islet transplantation.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Close N,Alejandro R,Hering B,Appel M,CITR Investigators.

doi

10.1016/j.transproceed.2006.10.014

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

179-82

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(06)01242-5

journal_volume

39

pub_type

杂志文章,多中心研究

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