Abstract:
:In this study we addressed the question of whether an underlying hematological malignancy may affect the immune response to vaccination against bacterial polysaccharide antigens (e.g. Haemophilus influenzae type b, Streptococcus pneumoniae) in splenectomized patients. Between 1993 and 2003, 44 splenectomized adults from the outpatient clinic for infectious diseases were prospectively included in the study: 23 patients suffered from hematological malignancies (HM) and had undergone splenectomy; 21 were splenectomized following trauma (T) and served as the control group. Each patient received an intradeltoid injection with 0.5 ml of a single lot of a 23-valent pneumococcal polysaccharide vaccine, and 0.5 ml of a polyribosyl ribitol phosphate capsular polysaccharide vaccine of H. influenzae type b (Hib) into the opposite arm. Blood samples for determination of pneumococcal and Hib antibodies were taken prior to vaccination and again 6-8 weeks later. In assessing responses to the 23-valent pneumococcal polysaccharide vaccine, we found significant differences in antibody titer increase between the HM and T groups (median IgG increase 1.27 [0.7; 2.39] vs. 3.9 [2.1; 15.3], P < 0.001; and median IgM increase 1.33 [1.0;2.67] vs. 5.25 [2.3; 7.78], P < 0.001). In the HM group, only 8/23 and 6/23 showed a titer increase of twice or more the base value for IgG and IgM respectively, whereas in the trauma group an adequate response was shown by 16/21 and 16/20 respectively. Patients with splenectomy and hematological malignancies responded poorly to the 23-valent polysaccharide vaccine. Response to the conjugated Hib vaccine was slightly better, but still significantly lower than in individuals with posttraumatic splenectomy. Data suggest that vaccination response to the polysaccharide vaccines should be evaluated at least in the high-risk group.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Eigenberger K,Sillaber C,Greitbauer M,Herkner H,Wolf H,Graninger W,Gattringer R,Burgmann Hdoi
10.1007/s00508-006-0752-5subject
Has Abstractpub_date
2007-01-01 00:00:00pages
228-34issue
7-8eissn
0043-5325issn
1613-7671journal_volume
119pub_type
杂志文章abstract::This paper reports on a case of attempted suicide by the rare means of prolonged inhalation of fumes from heated mercury. The patient developed symptoms of acute intoxication over a period of 4 to 24 hours after the suicide attempt. This phase consisted of pulmonary, intestinal, psychopathological and neurological sig...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1983-08-26 00:00:00
abstract::High levels of CA-125, the specific tumour marker for epithelial ovarian cancers are also found in inflammatory diseases of the pelvis. This case report of a 28 year-old woman with pathological CA-125 levels demonstrates the association between this finding and ascites caused by miliary tuberculosis. Tuberculostatic c...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1989-12-22 00:00:00
abstract::This paper analyzes the birth and death certificate data of infants who died from the Sudden Infant Death Syndrome (SIDS) before their first birthday. It investigates possible causes of differences in regional mortality and of the significant increase in the number of cases between 1980 and 1987. Moreover, the authors...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract::The nephrotoxic side effects of cyclophilin-binding agents like cyclosporine A and tacrolimus are well characterized. In severe cases nephrotoxicity may profoundly deteriorate kidney function and even induce acute renal failure. In this report we describe the first case of excessive tacrolimus intoxication caused by h...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:2000-11-10 00:00:00
abstract::Non invasive ventilation is defined as mechanical ventilation without the use of endotracheal intubation and has been increasingly established within intensive care units during the last decades. Negative pressure ventilation and non invasive positive pressure ventilation have been successfully applied, first in chron...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:1999-10-15 00:00:00
abstract::Rapid diagnosis of cerebral tuberculous meningitis is of the greatest importance in determining the outcome of therapy. Since tubercle bacilli are often not seen on microscopy of the cerebrospinal fluid, and culture of Mycobacterium tuberculosis takes many weeks, there is a need for more rapid and sensitive confirmato...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Although glucocorticoids have been universally implemented to stimulate fetal lung maturity, their effectiveness and side effects are still widely contested. In search of alternative drugs a double-blind study was conducted between June 1981 and June 1984 comparing betamethasone, a conventional corticoid, and ambroxol...
journal_title:Wiener klinische Wochenschrift
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-08-03 00:00:00
abstract::The impact factor (Institute for Scientific Information, ISI, Philadelphia, PA, USA) is a widespread used and acknowledged source for judging the quality of a researcher. In addition the "Science Citation Index (SCI)" [Institute for Scientific Information (ISI)] provides the scientific community with a citations datab...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:2001-08-16 00:00:00
abstract::Over the past years there has been great interest in developing diagnostic typologies of married couples undergoing therapy. 92 couples admitted to therapy were asked to fill out the Giessen test, a test widely used for diagnosis in marital therapy. The method of cluster analysis was used to find a classification. The...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1983-07-08 00:00:00
abstract::Doping is a phenomenon which in the past years through the various incidences in professional cycling has come more and more into the focus of the public interest. Whilst in the young past the problems were to define the term "doping" exactly, today's problem is to prevent adolescents and children of doping. This shal...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:10.1007/s00508-010-1383-4
更新日期:2010-06-01 00:00:00
abstract::According to the World Health Organization (WHO) the China office was first notified of cases of atypical pneumonia in Wuhan City on 31 December 2019. A viral genome sequence of a novel coronavirus, currently termed SARS-CoV‑2, with a disease process called COVID-19 was released 1 week later via online resources to ob...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:10.1007/s00508-020-01678-x
更新日期:2020-07-01 00:00:00
abstract::This review deals with the physiological and clinical importance of human atrial natriuretic peptide (hANP). This peptide, which is produced by the myocardial cells of the right atrium, induces a diuretic and natriuretic response and has an inhibitory effect on aldosterone secretion. Recent elucidation of the peptide'...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1987-03-06 00:00:00
abstract::Satellite associations and cell-cycle kinetics were investigated in short-term blood cultures from selected pairs of chromosomally normal persons and patients with trisomy 21. The cell-cycle duration was found to be longer in patients with trisomy than in normal persons. The frequency of satellite associations and the...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1981-01-09 00:00:00
abstract::Enzyme-cytophotometrical investigations allow evaluation of enzyme activity within single, morphologically classified cells. Special problems like development of blood cells, bone marrow cells or of macrophages may thus be studied. Knowledge about the kinetics of granulopoiesis allows a better understanding of altered...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1983-03-04 00:00:00
abstract::Skin and soft tissue infections (SSTIs) are among the most common health problems in travellers returning from tropical and subtropical countries. Importantly, the prevalence of Staphylococcus aureus, the most common pathogen for purulent SSTIs, with specific drug resistance, such as methicillin resistant Staphylococc...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-017-1243-6
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Rising costs of pharmaceuticals are a challenge to the public health care system. In collaboration with a company health insurance with 3143 members we analysed the economic benefit of reduced prescription fees for generic drugs in a 12-month period. METHODS:Within the observation period 1 euro per prescrip...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-007-0890-4
更新日期:2008-01-01 00:00:00
abstract::Before the introduction of the programme for the early detection of inborn errors of metabolism the discovery of the biochemical abnormality was merely the proof of a diagnoses based on characteristic features. Neonatal screening inverted the process and the biochemical anomaly became primary marker and symptoms were ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:1988-10-07 00:00:00
abstract::Chronic recurrent pulmonary embolism can lead to extensive pulmonary hypertension by obstruction of the pulmonary vessels. Pulmonary thrombendarteriectomy is a new approach to normalizing the elevated pulmonary vascular resistance by removal of the adsorbed thrombi. Between 1992 and 1994 we have operated on 8 patients...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::This mini-review conveys information on lung function in hypoxia. Included are presentations of shape and layering of the atmosphere, physiologic basics of lung function at high altitude, pathophysiology of high altitude pulmonary edema (HAPE) and of current and potential therapy approaches for HAPE. ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:10.1007/s00508-010-1501-3
更新日期:2011-02-01 00:00:00
abstract::A case of pelviscopic hysterectomy with uterine hyperflexion and cervical elongation is presented. In this case we were forced to extirpate the cervical fascia because of uterine hemorrhage by laparotomy after the cervical tissue punch had been performed. The histological findings were supravaginal cervical glands. Co...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The principle of the ultrasound examination of the heart is explained and the possible applications of this method are discussed. Three case histories are presented to exemplify the usefulness of echocardiography in clinical cardiology. ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1977-06-24 00:00:00
abstract::Side effects of vaccinations can have different causes. Substances admixed to vaccines may produce allergic or toxic reactions. The significance and importance of causal associations is discussed in this paper. A table is added listing the most important substances in vaccines, such as inactivating substances, preserv...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:10.1007/s00508-005-0405-0
更新日期:2005-08-01 00:00:00
abstract::The most common primary tumors of the cerebellopontine angle are growths of the 8th cranial nerve. The occurrence of other tumors in this area is very rare and may cause neuroradiological misinterpretation. We report the findings in a 37-year-old male patient suffering from a primitive neuroectodermal tumor (PNET) ext...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Titres of blood-group isoagglutinins and the serum concentration of immunoglobulins M and G were investigated in 388 inmates (89.7% females) of an old-age home, ranging in age from 78 to 99 years [mean (+/- s) = 85.7 years +/- 4.1 years]. Concentrations of isoagglutinins were positively correlated to the concentration...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1985-07-19 00:00:00
abstract::Supplement with keto acids/amino acids (KA) and erythropoietin can independently improve the metabolic sequels of chronic renal insufficiency. Our study was designed to establish whether a supplementation with keto acids/amino acids (KA) exerts additional beneficial metabolic effects in patients with chronic renal ins...
journal_title:Wiener klinische Wochenschrift
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2001-09-17 00:00:00
abstract::In a prospective study comprising 48 children (21 boys, 27 girls, age 12 months to 15 years) the hypothesis was tested whether an alteration in the light chain immunoglobulins kappa (kappa) and lambda (lambda) is an expression of autoimmune mechanisms and could be used as a diagnostic parameter. Immunoglobulins were a...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1990-04-13 00:00:00
abstract::Three patients among 107 operated on before 1985 according to Wilhelm's procedure for epicondylitis humero radialis showed no therapeutic response due to insufficient discission of the extensor carpi radialis brevis. We successfully used Garden's procedure at reoperation, with lengthening of the extensor carpi radiali...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::33 kidney tumours were detected in 15,500 routine scans of the upper abdomen. 13.7 per cent of these tumours were asymptomatic at the time of diagnosis. The size of these accidentally detected tumours was evidently smaller than in the case of symptomatic ones and the patients were younger at the time of diagnosis. The...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1987-12-18 00:00:00
abstract:BACKGROUND:Femoral short stems promise essential advantages in total hip arthroplasty. Up to now, only short- and midterm clinical studies exist. Data on early stem migration that could predict later aseptic loosening at an early stage are rare. The purpose of this study was to assess migration patterns and clinical ou...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-015-0756-0
更新日期:2015-05-01 00:00:00
abstract::Activation and inhibition of the calcium release channel of rabbit skeletal muscle heavy sarcoplasmic reticulum (HSR) was investigated by various methods. The calcium release channel is activated by binding of calcium in the micromolar range and by binding of adenine nucleotides in the millimolar range. Ruthenium red ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1990-10-26 00:00:00