Abstract：
:Before the introduction of the programme for the early detection of inborn errors of metabolism the discovery of the biochemical abnormality was merely the proof of a diagnoses based on characteristic features. Neonatal screening inverted the process and the biochemical anomaly became primary marker and symptoms were prevented by treatment. In reality, the subsequent development of symptoms was uncertain. In this way a great number of hitherto unknown metabolic anomalies was discovered. Screening methods for the first time allowed correct determination of the incidence of inherited disorders in different population. Important differences were uncovered intra- and internationally. Screening centres performing psychometry not only in homozygote patients, but also in heterozygote parents found that the heterozygotes for phenylketonuria (PKU) in spite of normal blood phenylalanine levels, are slightly subnormal intellectually. This is true also for early- and satisfactory-treated homozygotes. Increased intracellular phenylalanine concentrations in both could explain this slight intellectual subnormality which is, apparently, independent of the blood level. At least three treatment centres observed a decrease in IQ of 9 to 13 points between 1 and 8 years of age in early- and well-treated PKU patients being mostly still in the normal range. The IQ curves are parallel for these tree centres and independent of the age of diet discontinuation.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Thalhammer Osubject
Has Abstractpub_date
1988-10-07 00:00:00pages
641-5issue
19eissn
0043-5325issn
1613-7671journal_volume
100pub_type
杂志文章,评审abstract：BACKGROUND:Femoral short stems promise essential advantages in total hip arthroplasty. Up to now, only short- and midterm clinical studies exist. Data on early stem migration that could predict later aseptic loosening at an early stage are rare. The purpose of this study was to assess migration patterns and clinical ou...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-015-0756-0
更新日期：2015-05-01 00:00:00
abstract：:Non invasive ventilation is defined as mechanical ventilation without the use of endotracheal intubation and has been increasingly established within intensive care units during the last decades. Negative pressure ventilation and non invasive positive pressure ventilation have been successfully applied, first in chron...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-15 00:00:00
abstract：:Haemodynamic measurements were carried out after administration of furosemide to 10 patients suffering from acute myocardial infarction and congestive heart failure. It was observed that a transient deterioration in cardiac function (decreased cardiac output, increased enddiastolic pulmonary arterial pressure and incr...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1976-07-16 00:00:00
abstract：:Prostaglandins (PG) play an important role in the regulation of the renal blood flow and glomerular filtration rate. This study was designed to examine PG synthesis in the presence and absence of the ACE inhibitor captopril, PG binding to specific receptors and the ability of PG to stimulate cAMP accumulation in isola...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVES:Analysis of the fact that male medical students have a higher success rate at the written test (multiple-choice questions) at the end of the first study year (SIP-1), although female students perform significantly better in school (school marks in mathematics, physics, chemistry, and English) and school perf...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-007-0923-z
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to evaluate clinical outcome and patterns of disease progression relating to stenosis of the internal carotid artery (ICA) opposite to the operated side, using ultrasonographic risk score of ICA plaques. METHODS:150 patients who underwent ICA endarterectomy for transient ischemic at...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:The importance of hypercholesterolemia for the development of atherosclerotic lesions is undebatable. It is less evident, however, whether the progression of established lesions can be influenced by modifying lipid levels. The review of seven controlled angiographic intervention trials shows that different criteria ar...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：UNLABELLED:Rupture of the membranes before the fetus has achieved viability within the womb is an event of enormous importance for both mother and physician. The potential outcome ranges from fetal death, a frequent occurrence, to a severely disabled life or a happy (but rare) birth without any mental or physical retar...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-004-0246-2
更新日期：2004-10-30 00:00:00
abstract：BACKGROUND:Our aim in this study was to investigate whether mean platelet volume (MPV) value could be used as an early marker to predict pelvic inflammatory disease (PID). METHODS:Overall, 44 patients with PID and 44 healthy women were included in the study. The control group consisted of 44 women who applied to the c...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-014-0560-2
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:The goal of cardiac rehabilitation programs is not only to prolong life, but also to improve physical functioning, symptoms, wellbeing and health-related quality of life (HRQL). The aim of the study was to document short-term outcomes of cardiac rehabilitation programs in Austria. METHODS:Consecutive patien...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-006-0727-6
更新日期：2006-12-01 00:00:00
abstract：:Although glucocorticoids have been universally implemented to stimulate fetal lung maturity, their effectiveness and side effects are still widely contested. In search of alternative drugs a double-blind study was conducted between June 1981 and June 1984 comparing betamethasone, a conventional corticoid, and ambroxol...
journal_title：Wiener klinische Wochenschrift
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-08-03 00:00:00
abstract：PURPOSE:The aim of this systematic review is to provide an update on the effects of resistance exercise (RE) in patients with prostate cancer (PCa), with special attention to the effects on sexual health. METHODS:A systematic search of the literature was conducted in March 2020 using the databases PubMed, MEDLINE, EMB...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-020-01713-x
更新日期：2020-08-01 00:00:00
abstract：:Insulin resistance is a common characteristic of women with polycystic ovary syndrome (PCOS) who are known to differ in their in-vitro fertilization outcomes compared to non-PCOS patients. As insulin resistance can be found in a considerable proportion of normal individuals, we assessed its contribution to ovarian res...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：2002-06-28 00:00:00
abstract：:We report our initial experience with pulmonary function testing in neonates during intensive care, using an automated, computerized system (PEDS), which allows non-invasive and rapid determination of pulmonary mechanics and energetics such as compliance, resistance and respiratory drive, and measurement of lung volum...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:What clinicians expect from computers is contrasted with the actual potency of computerized data analysis. Different paths of procedure and the resulting chances of satisfactory implementation are discussed in the light of several specific cases. Additionally, examples are given both of highly efficient solutions and ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1987-11-20 00:00:00
abstract：:Urea and cyanate, spontaneously transformed from urea, are increased with decreased renal function becoming potential toxins. Isocyanic acid, the active form of cyanate, carbamoylates proteins, amino acids and other molecules, changing molecular structure and function in vivo. Carbamoylation can occur at multiple site...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：1998-08-21 00:00:00
abstract：:In an extensive series of experimental studies conducted on the common carotid artery in rats, a combined technique involving suture and gluing with human fibrin glue has been developed. In view of the good results achieved, this technique was then applied in 12 patients in whom anastomosis between the superficial tem...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1978-06-09 00:00:00
abstract：:Idiopathic bronchiolitis obliterans organizing pneumonia (idiopathic BOOP) and idiopathic CD4+ T lymphocytopenia are syndromes of unknown origins which have been characterized in recent years. An important feature of both syndromes is the good prognosis. The clinical and histological features of idiopathic BOOP are un...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:In order to investigate the association of urinary excretion of sodium and potassium with blood pressure, 72 prepubertal healthy children between 8 and 9 years were investigated in a cross sectional study. We determined anthropometric data, diastolic (DBP), and systolic blood pressure (SBP) and urinary excretion of so...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Poliomyelitis, an infectious disease with acute and persistent flaccid paralysis is caused by poliovirus (types 1, 2 or 3), an enterovirus. The infection is asymptomatic in 95% of infected subjects. Most of the paralytic cases occur in adolescents or adults in the course of polio type 1 infection. In the prevaccinatio...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：2001-10-30 00:00:00
abstract：:Interruption of an ongoing therapy with vitamin K antagonists (VKAs) is necessary in almost all patients undergoing major surgery. The purpose of the following expert recommendations is to provide easy to use guidance for the periprocedural management of patients on VKAs based on current evidence from the literature. ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-013-0390-7
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Preoperative hyponatremia and thrombocytosis are associated with perioperative morbidity in patients with epithelial ovarian cancer (EOC). The aim of the present study was to evaluate preoperative hyponatremia and thrombocytosis as prognostic parameters in patients with EOC. METHODS:In a retrospective cohor...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-018-1388-y
更新日期：2018-10-01 00:00:00
abstract：:This review deals with the physiological and clinical importance of human atrial natriuretic peptide (hANP). This peptide, which is produced by the myocardial cells of the right atrium, induces a diuretic and natriuretic response and has an inhibitory effect on aldosterone secretion. Recent elucidation of the peptide'...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1987-03-06 00:00:00
abstract：:The obstetrical management of pregnant women with pregestational diabetes has been significantly improved throughout recent years. In the past, efforts to maintain euglycaemia during pregnancy in the presence of a labile maternal metabolism led to repeated, long-term hospitalization. In an interdisciplinary joint effo...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1987-04-03 00:00:00
abstract：BACKGROUND:The obesity epidemic might affect patients with type 1 diabetes (T1DM), historically described as lean and insulin-sensitive subjects. Insulin resistance in T1DM might increase diabetic complications, especially cardiovascular disease. Therefore, the body mass index (BMI) in T1DM patients was analyzed in com...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-018-1434-9
更新日期：2019-02-01 00:00:00
abstract：:Total oesophageal resection for cancer is a major procedure, involving surgery within the thoracic cage, the abdomen and the cervical mediastinum. Plastic restruction using a segment of colon which is placed retrosternally between the cervical oesophagus and the stomach, is an additional procedure of considerable diff...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1975-09-19 00:00:00
abstract：:A central venous port catheter inserted infraclavicularily via the subclavian route may be compressed by the clavicle and the adjacent first rib. It's appearance on chest x-ray has been previously described as the 'pinch-off phenomenon' and requires the removal of the catheter due to a significant risk of fracture. We...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：2001-02-15 00:00:00
abstract：:In the introduction, the changes in the clinical features of tuberculosis over the past few decades are analyzed. Despite the reverse trend in incidence, tuberculosis is still one of the major infectious diseases in the world. The essential points in fighting tuberculosis are prophylaxis and early diagnosis, therapy h...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：:This review gives a historical overview about the development of today's understanding of benign thyroid diseases and the possibilities of their treatment.Little was known about the thyroid gland until the nineteenth century: the state of knowledge was (1) that something in food, especially in seaweed, avoided the dev...
journal_title：Wiener klinische Wochenschrift
pub_type： 历史文章,杂志文章
doi：10.1007/s00508-014-0515-7
更新日期：2014-05-01 00:00:00
abstract：:A statistic evaluation of the daily blood pressure values at rest during a 4-week period of active training combined with physiotherapy and medical baths indicated a decrease of 20 mm Bg in systolic pressure and of 9 mm Hg in diastolic pressure in patients with hypertension of various grades. The resting blood pressur...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1976-03-19 00:00:00
