Evaluation of cefotaxime in bacterial infections.

Abstract:

:Cefotaxime, a third generation cephalosporin antibiotic, was evaluated in 26 infants and children for the treatment of documented or suspected bacterial infections, including pneumonia (10 cases), soft tissue skin infection (13 cases), and urinary tract infection (3 cases). An average daily dose of 60 mg/kg in 3 to 4 divided doses was administered parenterally for an average of 7 days. In 14 of the cases, primary pathogens, including Haemophilus influenzae b (resistant to ampicillin), Staphylococcus aureus, Staphylococcus pyogenes, Streptococcus pneumoniae and Escherichia coli, were eradicated. Clinical recovery occurred in each case. Blood levels at different time intervals and biological half-life were similar to those reported for adults. Mild and transient side effects observed were elevation of SGOT in two cases, alkaline phosphatase in one, and eosinophilia in one case.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Varghese M,Khan AJ,Kumar K,Schaeffer HA,Pierro M,Evans HE

doi

10.1177/000992288402300406

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

220-2

issue

4

eissn

0009-9228

issn

1938-2707

journal_volume

23

pub_type

杂志文章
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