Abstract:
:Dextromethorphan hydrobromide (DXM), a constituent of more than 125 patent cough/cold remedies, is the most popular antitussive medication in the United States. Cough syrups or capsules also contain additional ingredients such as acetaminophen, chlorpheniramine maleate, guaifenesin, and/or pseudoephedrine, and toxicity with overdosage is additive to that of dextromethorphan alone. An unknown number of adolescents in the United States and Europe intoxicate themselves with acute megadoses of dextromethorphan. A megadose of DXM is defined as 5 to 10 times the dose recommended for control of annoying nonproductive coughs. Although a moderate overdose of pure DXM hydrobromide is free of serious adverse effects, approximately 5% of persons of European ethnicity lack the ability to metabolize the drug normally, leading to rapid acute toxic levels. Variable quantities of pure dextromethorphan powder in multiples of 1 gram are easily available from the worldwide web, including e-Bay. Recipe-like extraction procedures are quickly available on the Internet for seemingly simple and inexpensive home manufacture of concentrated dextromethorphan powder from Coricidin HBP Cough & Cold tablets (street name triple C). Adolescents intoxicate themselves at parties and even before or after school since the drug is legal, relatively inexpensive, and easily purchased or shoplifted at drug or convenient stores. Acute megadoses of the drug have profound psychological and physiological effects similar to those of phencyclidine (PCP). Megadoses of dextromethorphan used to self-intoxicate, can produce a false-positive screening test for phencyclidine in a urine specimen.
journal_name
Clin Pediatr (Phila)journal_title
Clinical pediatricsauthors
Schwartz RHdoi
10.1177/000992280504400702subject
Has Abstractpub_date
2005-09-01 00:00:00pages
565-8issue
7eissn
0009-9228issn
1938-2707journal_volume
44pub_type
杂志文章,评审abstract::IgG subclasses were measured in sera of 47 patients with acute hepatitis A during the course of the disease. IgG1 and IgG3 serum levels were found to be elevated, whereas IgG2 and IgG4 subclass concentrations did not differ from that found in healthy control individuals. These findings indicate that, similar to the sp...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289002900811
更新日期:1990-08-01 00:00:00
abstract::This study aims to evaluate the cost-benefit of vaccination services, mostly partial series administration, provided by a mobile clinic program (MCP) in Houston for children of transient and low-income families. The study included 469 patients who visited the mobile clinics on regular service days in 2 study periods i...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922820908586
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:To determine the incidence of serious bacterial infections in febrile children with sickle cell disease and to describe the outcomes of children discharged from the pediatric emergency department. METHODS:We conducted a retrospective chart review of 188 febrile patients with sickle cell disease presenting to...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922813488645
更新日期:2013-07-01 00:00:00
abstract::Fifty-eight growth hormone (hGH) deficient adults who had received long-term hGH therapy and their families were contacted to assess their past and current status regarding peer relationships, educational and vocational achievements, and self-concepts. Both heterosexual and same-sex peer relationships were reported as...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288602500103
更新日期:1986-01-01 00:00:00
abstract::Transient cataracts in patients with insulin-dependent diabetes mellitus (IDDM) are rare and have been reported only in association with severe ketoacidosis or hyperosmolarity. We present an adolescent with transient bilateral posterior subcapsular cataracts, which developed after the recent onset of IDDM without keto...
journal_title:Clinical pediatrics
pub_type: 信件
doi:10.1177/000992289303201108
更新日期:1993-11-01 00:00:00
abstract::A common presenting problem of children in pediatric practice is the constellation of symptoms involving difficulty in completing assignments, trouble with written work, and organizational problems. Typically, these children do not have difficulty with reading but show problems with academic achievement. We have recen...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288302200401
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND:Acid-suppressing agents have been associated with increased Clostridium difficile infection (CDI) in adults. The objective of this study was to evaluate the association of acid-suppressing therapy with the development of CDI in the pediatric population. METHODS:This was a retrospective case-control study. C...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922815569201
更新日期:2015-10-01 00:00:00
abstract::A 6-year-old girl with sickle cell disease was admitted to the hospital with the diagnosis of the acute chest syndrome. The laboratory findings and the radionuclear lung scan supported a diagnosis of pulmonary infarction rather than pneumonia. She improved with intravenous fluids, oxygen, penicillin, and theophylline....
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288502401209
更新日期:1985-12-01 00:00:00
abstract::To examine causes of newborn hospital readmission and morbidity related to early nursery discharge, we reviewed the charts of 664 newborns readmitted from home under the age of 15 days, between 1993 and 1995. Early discharge (ED) was defined as nursery length of stay of < or = 2 days. Morbidity related to ED: onset of...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289803701003
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:Often diapers are not changed after infants pass urine. AIM:To define the association between the frequency of changing diapers and urinary tract infection (UTI) in infants. METHODS:Urine samples were tested in 131 infants (aged from 2 months to 2.5 years) who had a temperature > or =38 degrees C. The auth...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922808320696
更新日期:2009-01-01 00:00:00
abstract::The purpose of this study was to examine the immunization beliefs and practices of physicians in our community. A two-page descriptive survey of immunization practices and knowledge of vaccine contraindications was sent to all community physicians on the staff of Children's Hospital Medical Center in Cincinnati, Ohio....
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289603500205
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVE:To describe the time and actions on 3 key health topics during health supervision (HS) visits of children aged 0 to 1 years. METHOD:HS visits were observed at 5 offices. Parents provided demographics and children's measurements were obtained. Using special computer software, visits were observed for frequenc...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922809337530
更新日期:2009-11-01 00:00:00
abstract::Much attention has been focused on the natural history of gastroesophageal reflux (GER) in neurologically normal infants which generally resolves by two years of age. In contrast, little is known of the outcome of GER diagnosed in normal older children. The charts of 32 children (21 males) without neurologic or esopha...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289103000705
更新日期:1991-07-01 00:00:00
abstract::Congenital right diaphragmatic hernia can present a difficult diagnostic problem. An illustrative case is reviewed in which the diagnosis was not considered during the initial hospitalization because chest radiographs were interpreted as showing an atelectatic and pneumonic process. Once suspected, the diagnosis was m...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288102000610
更新日期:1981-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Published data regarding outcomes of pediatric behavioral weight management are mainly from research interventions. The authors wished to explore outcomes from a clinical program. METHODS:A retrospective analysis of data from obese adolescents enrolled in the Michigan Pediatric Outpatient Weight E...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922810384845
更新日期:2011-03-01 00:00:00
abstract::Little is known of the characteristics of children experiencing school dysfunction who are evaluated by multidisciplinary teams. The records of 87 children seen during a calendar year were reviewed and information was gathered regarding their age, sex, and referral source. In addition, the chief concerns of the child'...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288802700406
更新日期:1988-04-01 00:00:00
abstract::An infant exposed in utero to valproic acid was born with multiple congenital malformations, including duodenal atresia, lumbar vertebral fusion, thoracolumbar scoliosis, renal abnormalities, diastasis recti abdominis, depigmentation of the eyebrows, and a large hemangioma. The child had neonatal hyperbilirubinemia an...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288402300611
更新日期:1984-06-01 00:00:00
abstract::Transient synovitis of the hip is a common cause of hip pain in children. The etiology of transient synovitis of the hip is unknown. Lyme arthritis is characterized by brief, often recurrent episodes of oligoarthritis. Lyme arthritis most often affects a single knee, but hip involvement is uncommon. This report descri...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922808318337
更新日期:2008-10-01 00:00:00
abstract::Anemia is defined as a reduction in red blood cell mass or hemoglobin concentration in blood. It is statistically differentiated from normal states as a hemoglobin concentration or hematocrit 2 SD below the mean for the healthy population adjusted for age and sex. Anemias may be classified based on the morphologic fun...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922808323115
更新日期:2009-01-01 00:00:00
abstract::The Bronx Ongoing Pediatric Screening (BOPS) project sought to improve screening for sexual activity and sexually transmitted infections (gonorrhea and chlamydia [GCC] and HIV) in a primary care network, employing a modified learning collaborative, real-time clinical data feedback to practices, improvement coaching, a...
journal_title:Clinical pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1177/0009922817733702
更新日期:2018-07-01 00:00:00
abstract::Antibiotics are widely prescribed for children with nonspecific upper respiratory tract infections, contributing to the recent emergence of resistant pneumococci. To understand the reasons for the overprescription of antibiotics, we conducted focus groups with parents and with pediatricians and family physicians to as...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289803701104
更新日期:1998-11-01 00:00:00
abstract::This study evaluated the taste palatability of liquid clindamycin and acetaminophen products on the market. Subjects rated the palatability of 3 clindamycin suspensions, 1 amoxicillin suspension (tasted twice), an acetaminophen elixir, and an acetaminophen suspension in a randomized blinded fashion on a 0 to 5 scale. ...
journal_title:Clinical pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1177/0009922816657151
更新日期:2017-02-01 00:00:00
abstract::A wide variety of types of pulmonary diseases and respiratory symptoms have been associated with gastroesophageal reflux (GER). Asthma, chronic bronchitis, bronchiectasis, and pulmonary fibrosis have all been linked to GER, but causal mechanisms have been difficult to establish. To characterize pulmonary function abno...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288602501101
更新日期:1986-11-01 00:00:00
abstract::Iron poisoning was a leading cause of pediatric morbidity and mortality. We sought to assess whether the removal of strict iron packaging requirements in 2003 resulted in an increase in iron-related morbidity and mortality in pediatric exposures. We performed a retrospective cohort study utilizing the National Poison ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922819901010
更新日期:2020-05-01 00:00:00
abstract::Families of 49 hearing-impaired children responded to a questionnaire requesting information about the identification of their child's hearing loss. Parents were the first to suspect the hearing loss in 48 cases but more often than not were told that the child would outgrow it or was too young to test. When profession...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289103000202
更新日期:1991-02-01 00:00:00
abstract::English- and Spanish-speaking parents of 1- to 5-year-old children were invited to view 5-10 minutes of parent training program, "Play Nicely," as part of the well-child checkup. Key measures were parents' plans to change how they discipline and, if they planned to use less spanking, how the program worked in their si...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922817693298
更新日期:2018-02-01 00:00:00
abstract::Ninety low socioeconomic adolescent females (aged 16-22 years, means 18.6 years) were screened for rubella immunity using a rubella IgG enzyme immunoassay. Data concerning past immunizations (with documentation, if possible), prior rubella disease, and previous pregnancies were gathered through direct interviews. Resu...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288502400705
更新日期:1985-07-01 00:00:00
abstract::Four neonates with adrenal hemorrhage are presented. The clinical manifestations included most often an abdominal mass but also anemia, jaundice, hypotension, bluish discoloration of the scrotum, and abdominal calcification. The diagnosis was established in each case upon abdominal sonographic findings. The review of ...
journal_title:Clinical pediatrics
pub_type: 杂志文章,评审
doi:10.1177/000992280104001002
更新日期:2001-10-01 00:00:00
abstract::Liquid antibiotics are often substantially more expensive than their pill counterparts, representing an opportunity for substantial cost reductions. Children can be taught to swallow pills at about age 6 years. The objective of this study was to calculate the potential cost saved by replacing liquid antibiotics with c...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922818774340
更新日期:2018-10-01 00:00:00
abstract::A study was undertaken to evaluate the trends in radiological follow up of childhood pneumonia among consultant pediatricians throughout the United Kingdom. A questionnaire was sent to 120 consultant pediatricians. Among the 88 respondents, 18% would carry out a repeat chest radiograph on follow-up of all their patien...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922806290055
更新日期:2007-03-01 00:00:00